Structure of PDB 6w6l Chain k Binding Site BS01

Receptor Information
>6w6l Chain k (length=84) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRNTTGTGRMRHLKIVYRRFRHGFREGTTPK
Ligand information
>6w6l Chain D (length=157) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgacucuuagcgguggaucacucggcucgugcgucgaugaagaacgcagc
uagcugcgagaauuaaugugaauugcaggacacauugaucaucgacacuu
cgaacgcacuugcggccccggguuccucccggggcuacgccugucugagc
gucgcuu
.........................................<<<<<<.<<
.....>>>.......<<<......>>.............>>>......>>
>....<<....>><<<<<<<<.......>>>>>>>>..............
.......
Receptor-Ligand Complex Structure
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PDB6w6l An ER translocon for multi-pass membrane protein biogenesis.
Resolution3.84 Å
Binding residue
(original residue number in PDB)		R20 R21 G23 K42 T59 G62 R63 M64 H66 L67 Y71 R72 F74 H76 R79 E80 G81 T82 T83
Binding residue
(residue number reindexed from 1)		R19 R20 G22 K41 T58 G61 R62 M63 H65 L66 Y70 R71 F73 H75 R78 E79 G80 T81 T82
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
GO:0097371 MDM2/MDM4 family protein binding
GO:1990948 ubiquitin ligase inhibitor activity
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:1901798 positive regulation of signal transduction by p53 class mediator
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0022626 cytosolic ribosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6w6l, PDBe:6w6l, PDBj:6w6l
PDBsum6w6l
PubMed32820719
UniProtP61927|RL37_HUMAN Large ribosomal subunit protein eL37 (Gene Name=RPL37)

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