Structure of PDB 5lzx Chain jj Binding Site BS01

Receptor Information
>5lzx Chain jj (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLNLVVIGHVDAGKSTLMGHMLYLLGNINKRTMHKYEQESKKAGKASFAY
AWVLDETGEERERGVTMDVGMTKFETTTKVITLMDAPGHKDFIPNMITGA
AQADVAVLVVDASRGEFEAGFETGGQTREHGLLVRSLGVTQLAVAVNKMD
QVNWQQERFQEITGKLGHFLKQAGFKESDVGFIPTSGLSGENLITRSQSS
ELTKWYKGLCLLEQIDSFKPPQRSIDKPFRLCVSDVFKDQGSGFCITGKI
EAGYIQTGDRLLAMPPNETCTVKGITLHDEPVDWAAAGDHVSLTLVGMDI
IKINVGCIFCGPKVPIKACTRFRARILIFNIEIPITKGFPVLLHYQTVSE
PAVIKRLISVLNKSTGEVTKKKPKFLTKGQNALVELQTQRPIALELYKDF
KELGRFMLRYGGSTIAAGVVTEIKE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5lzx Chain jj Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5lzx Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.
Resolution3.67 Å
Binding residue
(original residue number in PDB)		S274 T325
Binding residue
(residue number reindexed from 1)		S15 T66
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0016787 hydrolase activity
Biological Process
GO:0006412 translation
GO:0006414 translational elongation
GO:0006417 regulation of translation
GO:0007165 signal transduction
GO:0032790 ribosome disassembly
GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay
GO:0072344 rescue of stalled ribosome
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0022626 cytosolic ribosome
GO:0070062 extracellular exosome
GO:1990533 Dom34-Hbs1 complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5lzx, PDBe:5lzx, PDBj:5lzx
PDBsum5lzx
PubMed27863242
UniProtQ9Y450|HBS1L_HUMAN HBS1-like protein (Gene Name=HBS1L)

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