Structure of PDB 7a5i Chain j3 Binding Site BS01

Receptor Information
>7a5i Chain j3 (length=85) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGQWRLQQGLAANPSGYGPLTELPDWSYADGRPAPPMKGQLRRKAERETF
ARRVVLLSQEMDAGLQAWQLRQQKLQEEQRKQENA
Ligand information
>7a5i Chain A3 (length=1485) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagcc
aaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauau
aguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaag
gacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugc
aaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaac
agcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacacccacuaccuaaaaaauccc
aaacauauaacugaacuccucacacccaauuggaccaaucuaucacccua
uagaagaacuaauguuaguauaaguaacaugaaaacauucuccuccgcau
aagccugcgucagaucacacugacaauuaacagcccaauaucuacaauca
accaacaagucauuauuacccucacugucaacccaacacaggcaugcuca
uaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgcc
uguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgcc
ugcccagugacacauguuuaacggccgcgguacccuaaccgugcaaaggu
agcauaaucacuuguuccuuaaauagggaccuguaugaauggcuccacga
ggguucagcugucucuuacuuuuaaccagugaaauugaccugcccgugaa
gaggcgggcauaacacagcaagacgagaagacccuauggagcuuuaauuu
auuaaugcaaacaguaaccugcauuaaaaauuucgguuggggcgaccucg
gagcagaacccaaccuccgagcaguacaugcuaagacuucaccagucaaa
gcgaaccucaauugauccaauaacuugaccaacggaacaaguuacccuag
ggauaacagcgcaauccuauucuagaguccauaucaacaauaggguuuac
gaccucgauguuggaucaggacaucccgauggugcagccgcuauuaaagg
uucguuuguucaacgauuaaaguccuacgugaucugaguucagaccggag
uaauccaggucgguuucuaucuacuuuauuccucccuguacgaaaggaca
agagaaauaaggccuacuucacaaagcgccuucccccguaaaugauauca
ucucaacuuagauacccacacccaagaacaggguu
<<<.......<<<<....................................
<......>.....<.....<<.....>>....>...>>.>>.........
....<<....>>......................>>>...........<<
<.......>>>...<.<........>.>.<<<<<<.........<<<.<<
..<<....>>...>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<.
.<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>
>...<<.......>>......>.>>>>...>..>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>.........................
...........>...>>>>>>........>>>>>>...<<<<<......>
>>>>.........>>>>>>.......<<..<<<....>>><<<<..<<<<
........<<<<<......>>>>>......<<<...<<<<..........
.............>>>>.......>>>.....<<......>>.>>>>...
..>>>>..<<<<...<<<<<<<<.<<................<<<<<<..
<<<.........>>>...<<<<<<.............>>>>>>....<<<
.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>.......
.<...........<<<<<<.....>>>>>>.....>....>>>....>>.
>>>>........>>.>>>>>>>>>>>>.>>...........<<<<<....
....>>>>>.......<<..<<<.<<......<<<<.<<<<<<..<<<<<
.<<<<<<<<..........>>>>>>>>>>>>>..<<<<.....>>>><<<
<<<...........>>>>>>..<<.....<<<..<<<<.....>>>>..>
>>....>>.........<<<....>>>............>>>>..>>>>>
>.......<<<..<.<<<<<<...<<.......>>...>>>>>>...>.>
>.>.......<<<<<.<<<<<<..<<.<<<<<<......>>>>>>...>>
.<<<<<.....>>>>>.....>>>>>..>...>>>.>>....<<<<<<<.
...>>>.>>>>....>>..>>>.>>..<<<.<<<................
.>>>.>>><<<<<...<<<....>>>.>>>>>......<<<.........
.......>>>.........<<<<.......>>>>.
Receptor-Ligand Complex Structure
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PDB7a5i Elongational stalling activates mitoribosome-associated quality control.
Resolution3.7 Å
Binding residue
(original residue number in PDB)		G24 A35 N36 S38 K61 G62 R66 R76
Binding residue
(residue number reindexed from 1)		G1 A12 N13 S15 K38 G39 R43 R53
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0032543 mitochondrial translation
Cellular Component
GO:0005762 mitochondrial large ribosomal subunit

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7a5i, PDBe:7a5i, PDBj:7a5i
PDBsum7a5i
PubMed33243891
UniProtA8K7J6

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