Structure of PDB 7oya Chain j1 Binding Site BS01

Receptor Information

>7oya Chain j1 (length=86) Species: 7955 (Danio rerio)

TKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWSA
KAKRRSTTGTGRMRHMKVVFRRFRNGFREGTVPKPR

Ligand information

>7oya Chain 51 (length=3321)

cacgaccucagcucagacgagaagacccgcugaauuuaagcauauuacua
agcggaggaaaagaaaccaaccgggauucccccaguagcggcgagcgaag
agggaaaaguccagcgccgaauccccgccccagggcgagggaccuguggc
guacggagggccgccucucucggcgcgggggccaaaguccuucugaugga
ggcuuagcccgcggacggugugaggccggugucggcccccgccccgccgg
ggugcgguuccucccggagucggguuguuugggaaugcagcccaaagcgg
gugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagcggac
aaguaccgugagggaaaguugaaaagaacuuugaagagagaguucaacag
ggcgugaaaccguuaagagguaaacggguggggaccgcaccguccgcccg
guggauucagcccggcggggcggggucggcccguccgguggcucccuucg
cucccgcgggggguugacgcccgggcgaaggcucggccgccgccgggugc
auuuccgccgcgguggagcgccgcgaccggcuccgguucggcuuggaagg
gucagggggcgaagguuuuacagcgcccucccgccccgacuucgccgcuu
gcucuccggggccgcgggcccucucugcccucccucugcggggacggggu
cccccgcccccggcguggcgcgacagggguggacuguccucaguccgcug
cgccgcgccgcccagggcgggggacccacguucgggcgcccgagguccgc
ggcgacgccggccucccacccgacccgucuugaaacacggaccaaggagu
ccaacgcgcgcgcgagucagaggguggcucgcgagccccugcggcgcaau
gaaggugagggugggauccccccgccccggcggggggcgcaccaccggcc
cgccucgcgacccuccggggggcagguggaguuggagcgcgcgcgauggc
acccgaaagauggugaacuaugccugggcagggcgaagccaggggaaacu
cugguggaggcccgccgcgguccugacgugcaaaucggucguccgaccug
ggcauaggggcgaaagacuaaucgaaccaucuaguagcugguucccuccg
aaguuucccucaggauagcuggcgcucgccgaucaagcaguuuuauccgg
uaaagccaaugacuagaggcaccuauucucaaacuuuaaauggguaagag
gcccggcucgcuggcgcuggagccgggcguggaaugcgacgcgccuagug
ggccauuuuugguaagcagaacuggugcugcgggaugaaccgaacgccgg
guuaaggcgcccgaugccgacgcucaucagaccccauaaaagguguuggu
ugauauagacagcccgaaucaacuagcccugaaaauggauggcgcuggag
cgucgggcccauacccggccgucgacggcagcugcaagccucgacgagua
ggagggccgccgcgguggcgccgaagcccagggcgcgggcccggguggag
ccgccgcgggcgcagaucuuggugguaguagcaaauauucaaacgagagc
uuugaaggccgaaguggagaaggguuccaugugaacagcaguugaacaug
ggugagccgguccuaagggacgggccuacgccguucggaggggagggccc
cgcucgaccgaaagggagucggguccagauccccgagcccggagcggcgg
agacgggcgccgcgaggcgcccagugcggugacgcaaacgaacccggaga
ugccggcgggugccccgggaaagaguucucuuuucuuugugaagggcagg
gcgcccuggaacggguucgccccgagagaggggcccgcgcccuggaaagc
gccgcgcuucuggcggcguccggugagcucucgucggcccuugaaaaucc
gggggagaagguguaaaucucgcgccgggccguacccauauccgcagcag
gucuccaaggugaacagccucuggcguguuggaacaaggcagaguaaggg
aagucggcaagucagauccguaacuucgggauaaggauuggcucuaaggg
cugauagcagccagcuuagaacugucgcggaccaggggaauccgacuguu
uaauuaaaacaaagcaucgcgaaggcccucggcggguguugacgcgaugu
gauuucugcccagugcucugaaugucaaagugaagaaauucaacgaagcg
cggguaaacggcgggaguaacuaugacucucuuaagguagccaaaugccu
cgucaucuaauuagugacgcgcaugaauggaugaacgagauucccacugu
cccuaccugcuaucuagcgaaaccacagccaagggaacgggcuuggcaga
aucagcggggaaagaagacccuguugagcuugacucuagucuggcccugu
gaagagacuuuccucacuuacccggugaggcgggcuucuggcgucaagcg
ccccgcggggcgcgacccgccccggggacagcgucagguggggaguuuga
cuggggcgguacaccugucaaacgguaacgcagguguccuaaggcgagcu
caggggggacagaaaccucccguagagcagaagggcaaaagcucgcuuga
ucuugauuuucaguaugaguacggaccgcgaaagcggggccucacgaucc
uuccggcuuuugggguuuuaagcgggaggugucagaaaaguuaccacagg
gauaacuggcuuguggcggccaagcguucauagcgacgucgcuuuuugau
ccuucgaugucggcucuuccuaucauugugaagcagaauucaccaagcgu
uggauuguucacccacuaacagggaacgugagcuggguuuagaccgucgu
gagacagguuaguuuuacccuacugaugugagccguuguugcaauaguaa
ucccgcucaguacgagaggaaccgcggguucagacauuugguucgugcgc
uuggcugaggagccacuggcgcgaagccaccaucugcgggauuaugacug
aacgccucuaagucagaaucccgccuaaaagcaacgauaagcgccgucgg
aucuccgauaggccccggguaaccgggaccccggcgcggagagccauucg
ugacaggagcggcuagaacgagcgccgcccccucuuccagugacgcaccg
cauguuuguggggaacccggugcuuaaaugacucguagacgaccugauuc
ugggucggggugucgugcguggcagagcagcgcugcgauccauugaaagu
cagcccucgauccaaguuuug

.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<......<<.....>>....
.>>>>>..<<<..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>
>>..<<<<<<<<<<...<<<.<..<.<<<<<<<.....<<<<......>>
>>.....((......<<<.....))>>>.....>>>>>>>...>..>.>>
>..>>>>>.>>>>>.......<<<<<<<........>>>>>>>.....<<
<<<..((((((>>>>>..>>>.............................
.....<<....>>...............<<<<....>>>>..........
........................<<<<<<<<..<<<.......<<<<..
.<<<<....<<<<<<<<<.......<.<.<.<<<<.<..........<..
<.......>..>........>..>>>>..>..>.>....>>>>>>>>>..
...>>>>....>>>>.....<...<.<.<.<<<.<<...<....<<..<<
...<<<<.<<....<.>.....>>.>>>>....>>.........>>.>..
...>>..>>>.>.>........<.<<...<<<<.<..>.>>>>...<<<<
<..<<.<.<.<<<<<<...<<<<......<<<<<<<....>>>>>>>.>.
>>>.>>>>>>......>.>.>>>>>>>.......>>.>.......>....
>.......>>>...>>>>>>>>..<<<<........>>>><<<<<<....
<<<.<<<<<<<<<..<<<...<<<<.........>>>>....>>>...<<
....>>...<<<<<...<<<<<<<<....>>>>>>>>....>>>>><<<<
<<<<<.....<........>...>>>>>>.>>>...>>>>>>>>>.>>>.
.<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<......>
>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>
>>>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<.
...<.<<<....>>>.><<.<<<<<<<.........<<<.<<<<<<<<<.
..<<<....<<<....<<<..>>>....>>>..>.>>...>>>>>>>...
<<<<<<<<<..........>>>>>>>>>....>>>>>>>.>>>>>..>>.
.<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<
<<...<<<(((.......<<<<<.....<<..........<<<.<<<<<<
<<<<.......<.>...>>>>>>>>>>>>>..........))).>>...>
>>>>..>>>...>>>>>>><<<<<<.<<<........>>>>>>>>>....
>>>>>>.<.<<<<<<<<<<......<<<<.<<<<....>>>>>>>>...>
>>>>>>>>>..>.....>>>>>><<.....<<.....<<<<<<.......
>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>>>
>....((<<<<<<...<<....<<<....>>>............<...>.
.......>>....>>>..<<<<<........>>>>>))<<<<....<<<<
....<<<<<<<....>>>>>>>...<<<....>>>...<...<<<<<<..
.<<<<<<<<<.<<<<<<<.<<<<<<..[[[..>>>>>>....<<<<<.<<
<<.<<<<.....<<<.....>>>.....>>>>>>>>..>>>>>.....<<
<<<<<.......>>>>>>>>>>>.>.>>.>>>>>>>>>.........>>>
>>>...>..........>..>>>.>>>>.>>>..>>.....<<......>
>>>>>>.<<<<.....>>>>..>>>....<<<<....<<<<<.<<<.<<.
........<.....<<<<<.....<..>......>>>>><<.<<<<<<<<
<<<....>>>>>..>>>>>>.>>............<<<<<<<<<..<<<.
........>>>..<<<<<<<....<<<<.....>>>>......>>>>>>>
...<<..<<<..<<<<<<....<<<.....<<<<....>>>>.....>>>
.>>>>..>>>>>.<<<<<.......>>>>>.........<..........
.<<<<<.......>>>>>.....>.....>>....>>.>>>>>>>..>..
>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>....
<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<...<<
<<.<<<...>>>.>>>>...<<<<<.....<<<..............<<<
<<<<..>>>>>>>...>>>..>>>>>......>>>>>>>..>>>>>...<
<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<.
..<<<<<<.......>>>>>>.....<<.[.(((>>....>>>>>>>...
<<<..<<<<.......>>>>..>>>.<<<....>>>.>>)))].....<<
<<<<<..<<<..)))))).>>>>>>>>>>.........>>>>..>>>>>>
.......<<.<...<<<<<<...<<.......>>...>>>>>>....>.>
.>.......<<<<<.<<<<<<..<.<.<<<<<......>>>>>...>.>.
<<<.........>>>.....>>>>>..>...>>>.>>....<<<<<<<..
..>>>.>>>>....>>..>>>.>>>>>.......<<<<<<<<..<<<..<
.<<<<<.................>>>>>.><<<<....<<<<....<<<<
<<<<<.]]]..>>>>..>>>>>...>>>>...>>>><<<<<...<<<<<.
..........>>>>>...>>>>>.>>>...>>>>>>>>.<<<<<<...<.
..<<<<....<<..........<<<<<..>>>>>.........>>...<<
<.<..<<...<<<..........>>>.........>>...>.>>>.....
.........>>>>....>>>>>>>.<<<...<.............>....
<<<<<<<<<<..<.....<<<<....<<<<..>>>>...>>>>....>..
...>>>>.>>>>>>...>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oya A molecular network of conserved factors keeps ribosomes dormant in the egg.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): T2 K3 G4 T5 S6 F8 G9 K10 R11 R12 N13 K14 T15 H16 K25 H28 Q30 G35 K42 R43 K44 K46 Y47 N48 W49 S50 K52 A53 R55 R56 T59
• Binding residue (residue number reindexed from 1): T1 K2 G3 T4 S5 F7 G8 K9 R10 R11 N12 K13 T14 H15 K24 H27 Q29 G34 K41 R42 K43 K45 Y46 N47 W48 S49 K51 A52 R54 R55 T58

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006412 translation
• GO:0032981 mitochondrial respiratory chain complex I assembly
• GO:0033617 mitochondrial cytochrome c oxidase assembly

Cellular Component

• GO:0005743 mitochondrial inner membrane
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7oya, PDBe:7oya, PDBj:7oya
• PDBsum: 7oya
• PubMed: 36653451
• UniProt: Q6IQJ7