Structure of PDB 8p09 Chain j Binding Site BS01

Receptor Information
>8p09 Chain j (length=108) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVKR
LCHIRGKLRKKVWINTSDIILVGLRDYQDNKADVILKYNADEARSLKAYG
ELPEHAKI
Ligand information
>8p09 Chain 2 (length=1741) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcuacuuggauaacugugguaauuc
uagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgug
cauuuaucagaucaaaaccaacccggucgcggcuuuggugacucuagaua
accucgggccgaucgcagcccuccguggcggcgacgacccauucgaacgu
cugcccuaucaacuuucgaugguagucgccgugccuaccauggugaccac
gggugacggggaaucaggguucgauuccggagagggagccugagaaacgg
cuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccgacc
cggggagguagugacgaaaaauaacaauacaggacucuuucgaggcccug
uaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggaggg
caagucuggucgcagcagccgcgguaauuccagcuccaauagcguauauu
aaaguugcugcaguuaaaaagcucguaguuggaucuuguggaggguuccc
cgccccuugccucucggcgccggcccgaagcguuuacuuugaaaaaauua
gaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaauaau
ggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccauga
uuaagagggacggccgggggcauucguauugcgccgcuagaggugaaauu
cuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaauguu
uucauuaaucaagaacgaaagucggagguucgaagacgaucagauaccgu
cguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuauuc
ccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccggg
gggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggcacc
accaggaguggagccugcggcuuaauuugacucaacacgggaaaccucac
ccggcccggacacggacaggauugacagauugauagcucuuucucgauuc
ugugggugguggugcauggccguucuuaguugguggagcgauuugucugg
uuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcgacc
cccgagcggucggcgucccccaacuucuuagagggacaaguggcguucag
ccacccgagauugagcaauaacaggucugugaugcccuuagaugucgggg
cugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgccgg
caggcgcggguaacccguugaaccccauucgugauggggaucggggauug
caauuauuccccaugaacgaggaauucccaguaagugcgggucauaagcu
ugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacuacc
gauuggaugguuuagugaggcccucggaucggcccgccggggucccuggc
ggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaaguc
guaacaagguuuccguaggugaaccugcggaaggaucauua
...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[........<<.....<<.<<<.....>
>>.>>......>>.........<<<...<<.<......>.>>...>>>.[
[..(((((.....<<<<<<<<<<<<....>>>....<......>..))))
)......]]...<<<<.<<<......>>>.>>>>....]]]...}}....
]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>......
>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<..........>
>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<...
>>>>..>>>......}}.......<<<<<<.<<.<<<....>>>.>>..>
>>.>>>......<<..<...........>..>>.........<<<<<((.
...<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).]]
]............{{.......{{...[[[.[[....<<<<.<<<.>>>>
>>>.....<<.<......<<..>>....>>>..<<<<<<.<.......<<
...<.......>.<<<<.......>>>>...>>......>.>>>..>>>.
......[[....(((((((.....>>>>>>>>>.)))))))...]]....
]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>
>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>>.
>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>>>
>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<..
..>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>.....<
<<......<<<<....>>>>....>>>..]]]]..<<<<<.<<<<<<<..
<<..<<<<<..<<<.<<<<<<......<<........>>..........<
<<<<......<<<<<<.......<<.<<<........>>>.>>.....>>
>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......>>...<<<
......>>>...>>.>>>....<<<...<...<<<<..<<<<....<..<
..<<......>>>...>....>>>>..>>>>..>.....<<<<<.....>
>>>>........>>>....>>>.>>>.....>>>>>>>......>>>>>.
..>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<..
..>>>>.>>>....>.........>>>.>>......<.....<<<<<...
.......>>>>>.....>.....>>>>>.....<<<<<<<<.......>>
>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<<
....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<.>>>>>>>
>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>
>...>.....<<<<<<<<<....>>>>>>>>>.........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8p09 N 6 -methyladenosine in 5' UTR does not promote translation initiation.
Resolution3.3 Å
Binding residue
(original residue number in PDB)
K10 N11 R13 R14 K16 N44 G45 R62 G63 K64 R66 K67 W70 I71
Binding residue
(residue number reindexed from 1)
K3 N4 R6 R7 K9 N37 G38 R55 G56 K57 R59 K60 W63 I64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
Biological Process
GO:0006413 translational initiation

View graph for
Molecular Function

View graph for
Biological Process
External links
PDB RCSB:8p09, PDBe:8p09, PDBj:8p09
PDBsum8p09
PubMed38244546
UniProtG1SYS4

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