Structure of PDB 8eup Chain j Binding Site BS01

Receptor Information
>8eup Chain j (length=71) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSHTICRRCGKRSFHIQKSTCACCGYPAAKTRSYNWGAKAKRRRTTGTGR
MSYLKKVHRSFKNGFRSGKPA
Ligand information
>8eup Chain 1 (length=1422) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uugaccucaaaucagguaggacuacgcgcugaacaauaagcgcaggaaaa
gaaaauaaccaugauucccucaguaacggugaagcgggaaaagcucaaau
uugaaaucuggcaacauuucuuuuguuguccgaguuguaauuucaagaag
cugcuuugaguguagacgaucggucuaaguuccuuggaacaggacgucag
agagggugagaaccccgucuuuggucgauuggauaugccauauaaagcgc
uuucgaagagucgaguuguuugcagcucuaaauggguggucaucuaaagc
uaaauauuggcgagagaccgauagcgaacaaguagagugaucgaaagaug
aaaagaacuuugaaaagagaguuaaauaguacgugaaauugcugaaaggg
aagcauuggaaaucagucuuaccugggugagaucaguagucucucgagac
uaugcacucugaaccugugguaggucagcaucaguuuucgggggcggaaa
aagaauaagggaagguggcuguuuauagcccuuguuguaauacguccacu
ggggacugaggacugcggcuugccaaggaugcugacauaaugguuuucaa
uggcccgucuugaaacacggaccaaggagucuagcaucuaugcgaguguu
ugggugaugaaaacccauccgcgaaggugggaacgcccuuguggcgugca
ccaucgaagagcauagcuguugggacccgaaagauggugaaccaucuagu
agcugguuccugccgaaguuuccggauagcagaaacucagaucaguuuua
uguguaaaaugagaguuucuagugggccauuuuugguaagcagaacuggc
gaugcgggaugaaccgaacgugagguuaaggugccggaauguacgcucau
cagaaagguguuaguucauaugaacuagcccugggcgcuuaagcguacua
cccauaccucaccgucuggguuagcuuugagaagcucagacgaguaggca
ggcguggagguuugugacgaagccuugggcgugagccugggucgaacagc
cucuagugcagaucuugguggaaguagcuagaucuagcgaaaccacagcc
uggggaacgggccaggcaaucgucgcaaugguaauucaacuuaguacgag
aggaaccguugauucagaucauugguauuugcggccgcggagcuaucauc
ugccggauaacggcugaacgccucuaagccagaauccgugccagaaagcg
acgauuauguauaaaaauagagguaggcuacucuccuguaucguagaaga
ugggcgaugguugaugaaacggaaguguuuuauugacuuguccaugaaau
uccaugaauccauugcauacgacuuuaauguggaacgggguauugagauu
aagccuuuguucccaagauuug
.........................<<<<<........>>>>>.......
....<<....>>..<<<<<......<<.>>.....>>>>>..<<<...<.
......<<.<<<<<<<.......>>>>>>>.>>.......>.....<<<<
<.<<<<<..<<<<<..<<<<<<<<<.....<<<<......>>>>.((...
...<<<.....))>>>......>>>>>>>>>..>>>>>.....>>>>>>>
>.>>........<<<<<<<..>>>>>>>.....<<<<<..>>>>>..>>>
..................................<<....>>........
.......<<<<....>>>>...............................
...<<<<<<<<<<<<.....<<<.<<<<.<<<.<<.<<<<<<<..>>>>>
>>>>...>>>..>>>>..>>>..<<<<<<<.<<<<<<<<<<<<<<<....
......<<<<<.................>>>>>.........>>>>>.>>
>>>>>>>>........<<<..>>>.....>>>>>>>....>>>>>>>>>>
>>..<<<<........>>>><<<<<<....<<<<<<.<<<<<<..<<<..
.<<<<.......>>>>...>>>...<<<<<..<<<<<.....>>>>>...
>>>>>.....>>>>>>.>>>>>>..<<.<..<<<<<<<..>>>>>>>...
..>.>>..<<<<<<......<<..>>..<<<<<<<<<....<<<.<<<<<
<..>>>>>>>>>.>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>
....<<<......>>>...<<<<<<<...<<<(((.....<<<<<<....
.<<..<<<.<<<<<<<<<..>>>>>>>>>>>>.))).>>...>>>>>>.>
>>...>>>>>>><<<<<<<<<............>>>>>>>>>....>>>>
>>..<<<<<<<..<<......<<<<.<<<<....>>>>>>>>...>>.>>
>>>>>........>>>>>><<.....<<<<<..>>>>>....>>....<<
<<<........>>>>>...<<<<<<<..<<<<...<<<<<..........
.......>>>>>..<<<<<...<<<<....<<<..>>>...>>>>..>>>
>>.<<<<....<<<<...........>>>>....>>>>.>>>>....>>>
>>>>......<<.......<<<<..<..>..>>>>....>>........<
<<<<....<<<<<<<<<<<<......>>>>>>>>>>>>..>>>>>.....
.....<<<<<.<.............>.....<<<<<<<<<.<<<..>>>.
...>>>>.>>>>>...>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8eup Chromatin localization of nucleophosmin organizes ribosome biogenesis.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		H16 R25 S26 H28 K31 A35 C36 K43 T44 R45 Y47 N48 W49 K52 A53 R55 R56 H71 K75 G77 R79 S80 G81
Binding residue
(residue number reindexed from 1)		H3 R12 S13 H15 K18 A22 C23 K30 T31 R32 Y34 N35 W36 K39 A40 R42 R43 H58 K62 G64 R66 S67 G68
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0008270 zinc ion binding
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8eup, PDBe:8eup, PDBj:8eup
PDBsum8eup
PubMed36423630
UniProtP05733|RL37B_SCHPO Large ribosomal subunit protein eL37B (Gene Name=rpl3702)

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