Structure of PDB 8cgv Chain j Binding Site BS01

Receptor Information
>8cgv Chain j (length=123) Species: 679895 (Escherichia coli BW25113) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MIQEQTMLNVADNSGARRVMCIKVLGGSHRRYAGVGDIIKITIKEAIPRG
KVKKGDVLKAVVVRTKKGVRRPDGSVIRFDGNACVLLNNNSEQPIGTRIF
GPVTRELRSEKFMKIISLAPEVL
Ligand information
>8cgv Chain a (length=2687) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguuaagcgacuaagcguacacgguggaugcccuggcagucagaggcgau
gaaggacgugcuaaucugcgauaagcgucgguaaggugauaugaaccguu
auaaccggcgauuuccgaauggggaaacccaguguguuucgacacacuau
cauuaacugaauccauagguuaaugaggcgaaccgggggaacugaaacau
cuaaguaccccgaggaaaagaaaucaaccgagauucccccaguagcggcg
agcgaacggggagcagcccagagccugaaucaguguguguguuaguggaa
gcgucuggaaaggcgcgcgauacagggugacagccccguacacaaaaaug
cacaugcugugagcucgaugaguagggcgggacacgugguauccugucug
aauauggggggaccauccuccaaggcuaaauacuccugacugaccgauag
ugaaccaguaccgugagggaaaggcgaaaagaaccccggcgaggggagug
aaaaagaaccugaaaccguguacguacaagcagugggagcacgcuuaggc
gugugacugcguaccuuuuguauaaugggucagcgacuuauauucuguag
caagguuaaccgaauaggggagccgaagggaaaccgagucuuaacugggc
guuaaguugcaggguauagacccgaaacccggugaucuagccaugggcag
guugaaggucuaacuggaggaccgaaccgacuaauguugaaaaauuagcg
gaugacuuguggcugggggugaaaggccaaucaaaccgggagauagcugg
uucuccccgaaagcuauuuagguagcgccucgugaauucaucuccggggg
uagagcacuguuucggcaacccgaugcaaacugcgaauaccggagaaugu
uaucacgggagacacacggcgggugcuaacguccgucgugaagagggaaa
caacccagaccgccagcuaaggucccaaagucaugguuaagugggaaacg
augugggaaggcccagacagcgucgagucggccugcgcggaagauguaac
ggggcuaaaccaugcaccgaagcugcggcagcgacgcgcguuguugggua
ggggagcguucuguaagccugcgaaggugugcugugaggcaugcuggagg
uaucagaagugcgaaugcugacauaaguaacgauaaagcgggugaaaagc
ccgcucgccggaagaccaaggguuccuguccaacguuaaucggggcaggg
ugagucgaccccuaaggcgaggccgaaaggcguagucgaugggaaacagg
uuaauauuccuguacuugguguuacugcgaaggggggacggagaaggcua
uguuggccgggcgacgguugucccgguuuaagcguguaggcugguuuucc
aggcaaauccggaaaaucaaggcugaggcgugaugacgaggcacuacggu
gcugaagcaacaaaugcccugcuuccaggaaaagccucuaagcaucaggu
aacaucaaaucguaccccaaaccgacacagguggucagguagagaauacc
aaggcgcuugagagaacucgggugaaggaacuaggcaaaauggugccgua
acuucgggagaaggcacgcugauauguaggugaggucccucgcggaugga
gcugaaaucagucgaagauaccagcuggcugcaacuguuuauuaaaaaca
cagcacugugcaaacacgaaaguggacguauacggugugacgccugcccg
gugccggaagguuaauugaugggguuagcgcaagcgaagcucuugaucga
agccccgguaaacggcguaagguagcgaaauuccuugucggguaaguucc
gaccugcacgaauggcguaaugauggccaggcugucuccacccgagacuc
agugaaauugaacucgcugugaagaugcaguguacccgcggcaagacgga
aagaccccgugaaccuuuacuauagcuugacacugaacauauguucuaac
guugacccguaauccggguugcggacagugucugguggguaguuugacug
gggcggucuccuccuaaagaguaacggaggagcacgaagguuggcuaauc
agguuagugcaauggcauaagccagcuugacugcgagcgugacggcgcga
gcaggugcgaaagcaggucauagugauccggugguucugaauggaagggc
caucgcucaacggauaaaagguacuccggggauaacaggcugauaccgcc
caagaguucauaucgacggcgguguuuggcaccucgaugucggcucauca
cauccuggggcugaaguaggucccaaggguauggcuguucgccauuuaaa
gugguacgcgagcuggguuuagaacgucgugagacaguucggucccuauc
ugccgugggcgcuggagaacugaggggggcugcuccuaguacgagaggac
cggaguggacgcaucacugguguucggguugucaugccaauggcacugcc
cgguagcuaaaugcggaagagauaagugcugaaagcaucuaagcacgaaa
cuugccccgagaugaguucucccugacccuuuaaggguccugaaggaacg
uugaagacgacgacguugauaggccggguguguaagcgcagcgaugcguu
gagcuaaccgguacuaaugaaccgugaggcuuaaccu
<<<<<<<<......<<<<<<<<<<<.....[[..[[<<<<<<<[[<<...
...<<<<<<....(((.>>>.....<<<<<<<..<<<)))....>>>...
...>>>>>>>...>>>....<<<....>>><<<<<<<....>>>>>>>.<
<<<<<<<<.........>>>>>>>>>.>>...<<<<<<.....<<....>
>......>>>>>.>.........<<....>>..<<<<<<.....<<....
.>>....>>>>>>..(((..<<<<......<<<<<<<<<<<<<.<<<...
<<<<<......>>>>>((......<<<.....))>>>...>>>...>>>>
>>>>>>>>>...>>>>........<<<<<<<<.........>>>>>>>>.
.....<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]].....
..........<<....>>....]].........<<<<.....>>>>....
..............>>>>>>>>>>>.......<<<<..<<<<<<....>>
>>>>..>>>>...<............>.<<<<<<....<<<<<<<<<<<<
<..<<<...<<.....>>...>>>...<<....>>..<<<<.....>>>>
.....>>>>>>>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<
<<....<<<...>>>.....>>>...<<<.<<<<<........>>>>>>>
>....>>>>>>>>>...<<<.....>>>......>>>>>>......>.>>
..<<<<<<....<<<<<....>>>>>.<<<<<<<<...<<<<<<<<<...
..<<<...<<<.<<<<....>>>>.>>>..>>.>.....>>>>>>.>>>.
..>>>>>>>.>...<<<<<<<<<<......>>>>>>>>>>....<<<...
...>>>...<<<<.<<<...<<<(((.....<<<<<<...........<<
..<<<<<..<<........<..>....>>..>>>>>.>>...........
))).....>>>>>>.>>>...>>>>>>><<<<<<<<..>>>>>>>>....
>>>>>>..<<<<<...<<<......<<<<<<<<....>>>>>>>>...>>
>..>>>>>........>>>>>><......<<.....<<<<<<.......>
>>>>><<<<....<<<<<.<<...<<<<<<...<<.....>>.>>>>>>.
...((<<<.<<<...<<<...<<<....>>>...>>>...>>>..<<<<<
........>>>>>))<<<<<<<<<<<<<...<<<<....<<<<..<<<..
<<<<<<<<<<<....(((...>>>>>><<..<<<<...<<<<<<<<<<<<
.<<.....>>>>>>>>>>..>>>>...>>>>...>><..<<<<<....>>
>>>...>>>>>>...>>>...>>>>.........>>>>...>>....>>>
>>>>>>>>.>>>..>>.....<<......>>>>>>>.<<<<.....>>>>
..>>>>..<<<<....<<<<<<<<.<<...............<<<<<...
............>>>>><<<<<<.....<<<...<<<<.....>>>>...
>>>...>>>>>>............<<<<<<<<<..<<<.........>>>
..<<<<<<<.....<<<....>>>.......>>>>>>>.<<<<<.<<<..
<<<<<<<..<<<<...<...<<<<<..<<....>>...>>>>>..>....
>>>>>>>>>..>>>>>........<...........<<<<<<.....>>>
>>>.....>....>>>>>..>>.>>>>>>>.....>>.>>>>>>>>.>>>
>>>.....>.....<<<<<........>>>>>..<<<<<<<<.(((.[[.
.....<<<<.[[<<<<..<<<<<.<<<.<<<<<.<<<<<..>>>>>...<
<<.<<<<<<.....>>>>>>>>>....>>>>>.>>>..>>>>>..<<<<.
....>>>><<<<<<...........>>>>>>..<<...<<<<<<<...<.
>.....<<...(((>>....>>>>>>>...<<<<..<<<<....>>>>..
>>>>.<<<....>>>.>>))).......<<<<<<<.((..>>>>..))>>
>>>>>.............>>>>..]]>>>>.......<<<<...<<<<<<
...<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<
<..<<<<<<<<<......>>>>>>>..>>.<<<<<.....>>>>>.....
>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..))
)>>>>>>>>....<<<<<<<...<<<<..<<<<<<<..............
.>>>>>>>.<<<<<...<<<<...<<<<<<<<<<<))).>>>>>>..>>>
>>...>>>>.>>>>>...<<<....<<<<<...........>>>>>....
>>>.>>>>.......>>>>>>>..<<<<<.....>>>>><....<<..<<
<<<.......>>>>>....<<<<<<<<..<<....<<<<<....>>>>>.
..>>...>>>>>.>>>.....>>..>..>>>>>>>>.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8cgv Structural conservation of antibiotic interaction with ribosomes.
Resolution1.66 Å
Binding residue
(original residue number in PDB)		M1 Q3 E4 Q5 T6 M7 I22 K23 L25 G26 G27 S28 H29 R30 R31 Y32 K40 T42 K44 K54 V57 K66 K67 R70 G74 V76 R78 N82
Binding residue
(residue number reindexed from 1)		M1 Q3 E4 Q5 T6 M7 I22 K23 L25 G26 G27 S28 H29 R30 R31 Y32 K40 T42 K44 K54 V57 K66 K67 R70 G74 V76 R78 N82
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0070180 large ribosomal subunit rRNA binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8cgv, PDBe:8cgv, PDBj:8cgv
PDBsum8cgv
PubMed37550453
UniProtP0ADY3|RL14_ECOLI Large ribosomal subunit protein uL14 (Gene Name=rplN)

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