Structure of PDB 7ycx Chain j Binding Site BS01

Receptor Information
>7ycx Chain j (length=482) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DPNLWTVKCKIGEERATAISLMRKFIAYQFTDTPLQIKSVVAPEHVKGYI
YVEAYKQTHVKQAIEGVGNLRLGYWNQQMVPIKEMTDVLKVVKKSWVRLK
RGIYKDDIAQVDYVEPSQNTISLKMIPRIDYDRIKAPPQRLFDAEKIRSL
GGDVASDGDFLIFEGNRYSRKFLFKSFAMSAVITEGVKPTLSELEKFREH
NFQPGDNVEVCEGELINLQGKILSVDGNKITIMPKHEDLKDMLEFPAQEL
RKYFKMGDHVKVIAGRFEGDTGLIVRVEENFVILFSDLTMHELKVLPRDL
QLCSETASGVDVGGQHEWGELVQLDPQTVGVIVRLERETFQVLNMYGKVV
TVRHQAVTRKKDNRFAVALDSEQNNIHVKDIVKVIDGPHSGREGEIRHLF
RSFAFLHCKKLVENGGMFVCKTRHLVLANELIGQTVRISQGPYKGYIGVV
KDATESTARVELHSTCQTISVDRQRLTTVGSR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ycx Structural basis of INTAC-regulated transcription.
Resolution4.18 Å
Binding residue
(original residue number in PDB)		I285 K287
Binding residue
(residue number reindexed from 1)		I103 K105
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0006354 DNA-templated transcription elongation
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006368 transcription elongation by RNA polymerase II
GO:0016239 positive regulation of macroautophagy
GO:0032784 regulation of DNA-templated transcription elongation
GO:0032785 negative regulation of DNA-templated transcription, elongation
GO:0032786 positive regulation of DNA-templated transcription, elongation
GO:0034243 regulation of transcription elongation by RNA polymerase II
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0140673 transcription elongation-coupled chromatin remodeling
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0032044 DSIF complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ycx, PDBe:7ycx, PDBj:7ycx
PDBsum7ycx
PubMed36869814
UniProtO00267|SPT5H_HUMAN Transcription elongation factor SPT5 (Gene Name=SUPT5H)

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