Structure of PDB 7qh7 Chain j Binding Site BS01

Receptor Information

>7qh7 Chain j (length=86) Species: 9606 (Homo sapiens)

AGGQWRLQQGLAANPSGYGPLTELPDWSYADGRPAPPMKGQLRRKAERET
FARRVVLLSQEMDAGLQAWQLRQQKLQEEQRKQENA

Ligand information

>7qh7 Chain A (length=1256)

gcuaaaccuagccccaaacccccaccuuacuaccacaacuuagccaaacc
auuuacauaaaguauaggcgauagaaauugauggcgcaauagauauagua
ccgcaagggaaagacaagcauaauauagcaaggacuaaccccuauaccuu
cugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaa
gacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacaccc
gucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccu
accgagccuggugauagcugguuguccaagauagaaucuuaguucaacuu
uaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuagucca
aagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaa
aaaaugaucccaaacauauaacugaacuccucacacccaauuggaccaau
cuaucauauagaagaacuaauguuaguauaaguaacaugaaaacauucuc
cuccgcauaagccugcgucagaucugacaauuaacagcccaauaucuaca
aucaaccaacaaguuauuacccucacugucaacccaaccaggcaugcuca
uaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgcc
uguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgcc
uccuuaaauaggcuccacgaggguucagcugucucuuacuuuuaaccagu
gaaauugaccugcccgugaggcgggcauaacacagcaagacgaagacccu
auggagcuuuaauuuauuaaugcaaaaccugcauuaaaaauuucgguugg
ggcgaccucggagcagaacccaaccuccgaggcuaagacuucaccaguca
aagcgaagauccaauaacuugaccaacggaacaaguuacccuagggcaau
ccuauucuagaguccauaucaacaauaggguuuacuggaucaggacaucc
cgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccu
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
auuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagc
gccuucuaaaugauaucaucucaacuuaauacccacacccacccaagaac
aggguu

<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>....>>.>>.............
<<....>>........>>>...........<<<.......>>>...<.<<
......>>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>
>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<
..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>.
.....>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<
<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<
<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...
<.....................>...>>>>>>........>>>>>>...<
<<<<...>>>>>.........>>>>>><......<<..<<<....>>><<
<<..<<<<........<<<<<..>>>>>......<<<...<<<<......
..............>>>>.......>>>.....<<.....>>.>>>>...
..>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..
<<<.........>>>...<<<<<<.............>>>>>>.......
.<<<.....>>>.....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>
.....>.....<<<<<.....>>>>>.......<<..<<<.<<...<<<<
<.<<<<<<..<<<<..<<<<<<<<.....>>>>>>>.>>>>>..<<<<..
...>>>><<<<<<...........>>>>>>.<<<..<<<<.....>>>>.
.>>>.......<<<....>>>............>>>>..>>>>>>>...<
<<<<<<...<<.......>>...>>>>>>>.....<<<<..<<<<<..<<
.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>
.....>>>>......<<<<<<<....>>>.>>>>....>>..>>>.>>..
<<<.<<<.................>>>.>>><<<<<...<<<....>>>.
>>>>>.<<<................>>>............<<<<......
.>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qh7 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): A23 N36 S38 M60 K61 G62 R65 R66
• Binding residue (residue number reindexed from 1): A1 N14 S16 M38 K39 G40 R43 R44

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005762 mitochondrial large ribosomal subunit

External links

• PDB: RCSB:7qh7, PDBe:7qh7, PDBj:7qh7
• PDBsum: 7qh7
• PubMed: 35177605
• UniProt: Q86TS9|RM52_HUMAN Large ribosomal subunit protein mL52 (Gene Name=MRPL52)