Structure of PDB 7pwg Chain j Binding Site BS01

Receptor Information
>7pwg Chain j (length=87) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKGTASFGKRHTRIHGSCRRCGKHSFHLQKHECASCGYPSAKMRRYNWSY
KSLRRRTQGTGSMSHMRKVYRAYNSGTLKANARKYLA
Ligand information
>7pwg Chain 1 (length=2450) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguacgc
cccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcggga
ggagcccgccccgaaggcgcgcugugggcgccgcgagggggcccgagggc
cccgcccgagagggugcaagccccguacggcgggcgaguagcgcugcuug
agcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgcccc
gggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgccc
ggccgcucaaaagaccugaacccggccggcgccggcccgccggccccguc
ucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggccccg
cggcggagcgagcgcgagacgccccgggcccgccgcgccccugcgggcgu
gcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugccc
ggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcug
acgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucga
accgccugguagcugguugccuccgaaaugucucccaggacagccgccgc
ccgcaguugcggcccguagagcgcuggccggcggccgccccccaaacucc
gaagggccgcgccgccccgcccuggccugggcggggcgggcgaaugcggg
cggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgaucc
ggacgccgggccagggugcgccgccggggccggaacggcgucggccgcgg
ccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgc
cgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgc
gcaggccccgccggaccggccucuggugcagaucucggcagcaguagcgc
uacuccgcgccccggaggacugagggggagacggguuccgcggcgccugc
aucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaagg
ggcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcg
ggcggagacgcgccccccggcgacgcgcacggggaccgcggcgggcggcg
ccccggcccgcgaacgccccgcagcccccggacgccuugcgcggagaggg
gggcccgggggcggaccgcgcguccccggccgccccugaaaagccggggg
gcccgcgcgccguaccgaccgcacaggacuccggggucagcagccucuag
cgcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccu
cgggaaaaggaguggcucugacggggucagaacuggaacggacgcgggga
ucccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcu
ggcgcgacgugauuucugcccagugccagaccgucaccgugaagcgaucc
gccgaagcccugguaaacggcgggaguaaugacucucuuaagguagccaa
augccucgucgggcaauuuccgacggcaugaauggaccaacgaggauccc
acugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgag
ggccggccagcggggcaagaagacccuuuugagcuugacuccagcccggg
ccuguggggcggggccgccccgcucacccggucgcgcggggacccgcccg
ggcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcg
ucccacggcgggcucagcgaggacccucccgcggagcagaagggcacaag
cccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggcc
uaccgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguu
accacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggc
uuuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgc
ggaagcgucggauuguucacccguucaagggaucgugagcuggguuuaga
ccgucgugagacgguuaguuuuacccuacuggccccggggccagagcacg
gcgggccaguacggaggaacgcccgccgcgggcgcccagccccgcgguug
cccgccggggcaggaccgcgcgcccgggcccgggggccuggcgcugccgc
cucuaaagcgccaccccccccuccggccccgccgcccgcgccccagcccc
gugcccccugcccgaggcggcccccgcccgggaggaccacccggcgcggc
gccccuguacggcgagggcgcguucgcccggggggcgcgccgcgggcgcg
......................<<<<<<.....<<....>>......>>>
>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>
>..[[[...<<<<...........>>>><<<<.....<<<<<......>>
>>>((......<<<.....))>>>....>>>>........<<<<<<<...
.....>>>>>>>...(((((..<<<<<<)))))..]]]............
......................<<....>>................<<<.
>>>...........................<<<<<<..>>>>>>.<<<<.
.......>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<.>>>.
.>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>
>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<
<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<
<........>>>>.>>>....>>>>>>>>>...<<.......>>......
>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<
<<<<<.<<<<<<<<<...<<<...<<<..<<<<..>>>>..>>>..>>.>
...>>>>>>>.<<<<<<<<<<<......>>>>>>>>>>>...>>>>>>>>
>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>
>...<<<<<<<..<<<<(((...<<<<<<<.....<<<.<<<<<<<..>>
>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<
<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<<<<.<<
....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<.....<<..
..<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<...<...
....>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<
<<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<
<<<<....>>><<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<....
.....>>>>>....<<<<<<...<<<<<<....<<.....>>......>>
>>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>
>>>>>>>>.>>>..>>..<<.....>>.>>>>.<<<<.....>>>>..>>
....<<<<....<<<<<<<<.<<.........<.....<<<<<....<<.
.>>.....>>>>><<.<<<<<<...>>>>>>.>>............<<<<
<<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>...
...>>>>>>>...<<..<<<..<<<<<<<...<<....<<<.<....>.>
>>....>>.>>>>>..>>>>><<<<<<....>>>>>>........<....
.......<<<<<<.....>>>>>>....>.....>>....>>.>>>>>>>
..>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>
>...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<
<..<<<<<<<<<..>>>>>>>>>...<<<<......>>>>.....>>>>>
>>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>.
.<<...<<<<<<<...<.<<<<..>>>>.>.....<<...(((>>....>
>>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))
).......(((((.(((((.>>>>>>))))))))))..........]]]]
..}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>
>...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>
>>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<
<<<<<....>>>>>>>........}}}.))))))..<<<<<<.<<<..<<
<<<<<<..............>>>>>>>><<<<<...<.<....<<<<<<<
<<<....>>>>>..>>>>>....>.>.>>>>>.<<<...<<<<<<.....
......>>>>>>...>>>..>>>.>>>>>>...<.<<<............
.................>>>.>...<<.<<<<.......>>>>..<<<<<
<<<<<<....<<<<<<.<..>.>>>>>>...>>>>.>>>>>>>....>>.
Receptor-Ligand Complex Structure
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PDB7pwg Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		S2 K3 T5 S7 F8 G9 K10 R11 H12 T13 R14 I15 H16 H25 S26 H28 Q30 A35 K43 R45 Y47 N48 W49 Y51 K52 S53 R55 R56
Binding residue
(residue number reindexed from 1)		S1 K2 T4 S6 F7 G8 K9 R10 H11 T12 R13 I14 H15 H24 S25 H27 Q29 A34 K42 R44 Y46 N47 W48 Y50 K51 S52 R54 R55
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pwg, PDBe:7pwg, PDBj:7pwg
PDBsum7pwg
PubMed35100413
UniProtA8BLV7

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