Structure of PDB 7og4 Chain j Binding Site BS01

Receptor Information

>7og4 Chain j (length=86) Species: 9606 (Homo sapiens)

AGGQWRLQQGLAANPSGYGPLTELPDWSYADGRPAPPMKGQLRRKAERET
FARRVVLLSQEMDAGLQAWQLRQQKLQEEQRKQENA

Ligand information

>7og4 Chain XA (length=1498)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcacacccgucuauguagcaaaauaguggg
aagauuuauagguagaggcgacaaaccuaccgagccuggugauagcuggu
uguccaagauagaaucuuaguucaacuuuaaauuugcccacagaacccaa
auccccuuguaaauuuaacuguuaguccaaagaggaacagcucuuuggac
acuaggaaaaaaccuuguagagagaguaaaaaauuuaacacccauaguag
gccuaaaagcagccaccaauuaagaaagcguucaagcucaacaccaaaaa
ucccaaacauauaacugaacuccucacacccaauuggaccaaucuaucac
ccuauagaagaacuaauguuaguauaaguaacaugaaaacauucuccucc
gcauaagccugcgucagauaacaacugacaauuaacagcccaauaucuac
aaucaaccaacaagucauuauuacccucacugucaacccaacacaggcau
gcucauaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuacc
ccgccuguuuaccaaaaacaucaccucuagcaucaccaguauuagaggca
ccgccugcccagugacacauguuuaacggccgcgguacccuaaccgugca
aagguagcauaaucacuuguuccuuaaauagggaccuguaugaauggcuc
cacgaggguucagcugucucuuacuuuuaaccagugaaauugaccugccc
gugaagaggcgggcauaacacagcaagacgagaagacccuauggagcuuu
aauuuauuaaugcaaacaguaaccaaaccugcauuaaaaauuucgguugg
ggcgaccucggagcagaacccaaccuccgagcaguacaugcuaagacuuc
accagucaaagcgaaccucaauugauccaauaacuugaccaacggaacaa
guuacccuagggauaacagcgcaauccuauucuagaguccauaucaacaa
uaggguuuacgaccucgauguuggaucaggacaucccgauggugcagccg
cuauuaaagguucguuuguucaacgauuaaaguccuacgugaucugaguu
cagaccggaguaauccaggucgguuucuaucuacuuauuccucccuguac
gaaaggacaagagaaauaaggccuacuucacaaagcgccuucccccguaa
augauaucaucucaacuuagauacccacacccacccaagaacaggguu

<<<.......<<<<....................................
.<......>.........<.....<<.....>>....>........>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....
<<<<<.<<<..<<<.....>>>...<<<..<<<<........>>>>.>>>
....>>>.>>>>>...<<.......>>......>.>>>>...>..>.>>.
.<<<<<<....<<<<....>>>><<<.<<<<<<<<<<.....<<......
.>>.....>>>>>>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>
...<<<......>>>....<<<.<<<...<..............<....<
<<.........>>>....>.......<<<......>>>............
...............>...>>>>>>........>>>>>>...<<<<<...
...>>>>>.........>>>>>><......<<..<<<....>>><<<<..
<<<<........<<<<<.......>>>>>......<<<...<<<<.....
..................>>>>.......>>>.....<<......>>.>>
>>.....>>>>..<<<<...<<<<<<<<.<<.........<......<<<
<<<..<<<.........>>>...<<<<<<.............>>>>>>..
..<<<.<<<..<<<<<....>>>..>>>>><<<<<<......>>>>>>..
......<...........<<<<<<.....>>>>>>.....>....>>>..
..>>.>>>>.....>..>>.>>>>>>>>>>>>.>>.....>.....<<<<
<........>>>>>.......<<..<<<.<<......<<<<.<<<<<<..
<<<<<.<<<<<<<<...............>>>>>>>>>>>>>..<<<<..
...>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<..
...>>>>..>>>....>>.........<<<....>>>............>
>>>..>>>>>>.......<<<..<.<<<<<<...<<.......>>...>>
>>>>...>.>>.>.......<<<<<.<<<<<<..<<.<<<<<<......>
>>>>>...>>.<<<<<.....>>>>>.....>>>>>..>...>>>.>>..
..<<<<<<<....>>>.>>>>....>>..>>>.>>.<<<.<<<.......
..........>>>.>>><<<<<...<<<....>>>.>>>>>......<<<
................>>>.............<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7og4 Structural basis of mitochondrial translation.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): A23 G24 Q26 N36 S38 G39 T44 M60 K61 G62 R65 R66
• Binding residue (residue number reindexed from 1): A1 G2 Q4 N14 S16 G17 T22 M38 K39 G40 R43 R44

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7og4, PDBe:7og4, PDBj:7og4
• PDBsum: 7og4
• PubMed: 32812867
• UniProt: Q86TS9|RM52_HUMAN Large ribosomal subunit protein mL52 (Gene Name=MRPL52)