Structure of PDB 7of2 Chain j Binding Site BS01

Receptor Information

>7of2 Chain j (length=84) Species: 9606 (Homo sapiens)

GGQWRLQQGLAANPSGYGPLTELPDWSYADGRPAPPMKGQLRRKAERETF
ARRVVLLSQEMDAGLQAWQLRQQKLQEEQRKQEN

Ligand information

>7of2 Chain A (length=1410)

gcuaaaccuagccccaaaccccaccuuacuaccagacaaccuuagccaaa
ccauuuacauaaaguauaggcgauagaaauugauggcgcaauagauauag
uaccgcaagggaaagaugaaaaaccaagcauaauauagcaaggacuaacc
ccuauaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagag
ccaaagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaaa
gagcacacccgucuauguagcaaaauagugggaagauuuauagguagagg
cgacaaaccuaccgagccuggugauagcugguuguccaagauagaaucuu
aguucaacuuuaaauuugcccacagaacccucuaaauccccuuguaaauu
uaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaaccu
uguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagcca
ccaauuaagaaagcguucaagcucaacacaaaaaucccaaacauauaacu
gaacuccucacacccaauuggaccaaucuaucacccuauagaagaacuaa
uguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcguca
gauacugacaauuaacagcccaauaucuacaaucaaccaacaagucauua
uuacccucacugucaacccaacacaggcaugcucauaaggaaagguuaaa
aaaaguaaaaggaacucggcaaaucuuaccccgccuguuuaccaaaaaca
ucaccucuagcaucaccaguauuagaggcaccgccucacuuguuccuuaa
auagggaccuguauggcuccacgaggguucagcugucucuuacuuuuaac
cagugaaauugaccugcccgugaagaggcgggcauaacacagcaagacga
gaagacccuauggagcuuuaauuuauuaaugcaaacaccugcauuaaaaa
uuucgguuggggcgaccucggagcagaacccaaccuccgagcaguacaug
cuaagacuucaccagucaaagcgaaccucaauugauccaauaacuugacc
aacggaacaaguuacccuagggauaacagcgcaauccuauucuagagucc
auaucaacaauaggguuuacgaccucgauguuggaucaggacaucccgau
ggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccuacgu
gaucugaguucagaccggaguaauccaggucgguuucuaucuacuuuaau
uccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagcgc
cuucccccguaaaugauaucaucucaacuuaguauuauacccacacccaa
gaacaggguu

<<<.......<<<<.................................<..
....>...........<<.....>>.........>>.>>...........
..<<....>>................>>>...........<<<.......
>>>...<.<........>.>.<<<<<<.........<<<.<<..<<....
>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..<<<....
.>>>...<<<<.<<<<........>>>>>>>>....>>>.>>>>>...<<
.......>>......>.>>>>......>.>>..<<<<<<....<<<<...
.>>>><<<.<<<<<<<<<<.....<<..........>>.....>>>>>>>
>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>>>
.>..<<<.<<<...<..............<....<<<.........>>>.
...>.......<<<......>>>..........................>
...>>>>>>........>>>>>>...<<<<<......>>>>>........
.>>>>>><......<<..<<<....>>><<<<..<<<<........<<<<
<...>>>>>......<<<...<<<<.......................>>
>>.......>>>.....<<......>>.>>>>.....>>>>..<<<<...
<<<<<<<<.<<................<<<<<<..<<<.........>>>
...<<<<<<.............>>>>>>....<<<..<<..<<<<<<...
..>>>>>>..>>..>>>....>>.>>>>........>>.>>>>>>>>>>>
>.>>.....>.....<<<<<........>>>>>.......<<..<<<.<<
......<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>>>>>>>>>
>>..<<<<.....>>>><<<<<<...........>>>>>>..<<.....<
<<..<<<<.....>>>>..>>>....>>.........<<<....>>>...
.........>>>>..>>>>>>.......<<<....<<<<<<...<<....
...>>...>>>>>>.....>>.>.......<<<<<..<<<<<..<<.<<<
<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>....
..>>>>.>....<<<<<<<....>>>.>>>>....>>..>>>.>>...<<
<.<<<.................>>>.>>><<<<<...<<<....>>>.>>
>>>......<<<................>>>.............<<<<..
.....>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7of2 Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): G24 G25 N36 P37 S38 M60 K61 G62 R65 R66 R76
• Binding residue (residue number reindexed from 1): G1 G2 N13 P14 S15 M37 K38 G39 R42 R43 R53

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005654 nucleoplasm
• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7of2, PDBe:7of2, PDBj:7of2
• PDBsum: 7of2
• PubMed: 34135319
• UniProt: Q86TS9|RM52_HUMAN Large ribosomal subunit protein mL52 (Gene Name=MRPL52)