Structure of PDB 7ezj Chain j Binding Site BS01

Receptor Information

>7ezj Chain j (length=196) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PSNTDYPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKV
STPPPPGTAIRAMPVYKKAEHVTDVVKRCPNHELGRDFNEGQSAPASHLI
RVEGNNLSQYVDDPVTGRQSVVVPYEPPQVGTEFTTILYNFMCNSSCVGG
MNRRPILIIITLEMRDGQVLGRRSFEGRICACPGRDRKADEDHYRE

Ligand information

>7ezj Chain m (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

caggcatgcctg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	7ezj Deciphering the mechanism of p73 recognition of p53 response elements using the crystal structure of p73-DNA complexes and computational studies.
Resolution	2.9 Å
Binding residue (original residue number in PDB)	S261 R268 R293 A296 C297 R300
Binding residue (residue number reindexed from 1)	S146 R153 R178 A181 C182 R185

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000976	transcription cis-regulatory region binding
GO:0003677	DNA binding
GO:0003700	DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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Cellular Component

External links

PDB	RCSB:7ezj, PDBe:7ezj, PDBj:7ezj
PDBsum	7ezj
PubMed	35217090
UniProt	O15350\|P73_HUMAN Tumor protein p73 (Gene Name=TP73)

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