Structure of PDB 6nu2 Chain j Binding Site BS01

Receptor Information

>6nu2 Chain j (length=85) Species: 9606 (Homo sapiens)

GGQWRLQQGLAANPSGYGPLTELPDWSYADGRPAPPMKGQLRRKAERETF
ARRVVLLSQEMDAGLQAWQLRQQKLQEEQRKQENA

Ligand information

>6nu2 Chain A (length=1472)

gcuaaaccuagccccaaacccacuccaccuuacuaccagcaaccuuagcc
aaaccauuuacauaaaguauaggcgauagaaauuguggcgcaauagauau
aguaccgcaagggaaagaugaaaaauuauaaccaagcauaauauagcaag
gacuaaccccuauaccuucugcauaaugaauuaacuagaaauaacuuugc
aaggagagccaaagcuaagacccccgaaaccagacgagcuaccuaagaac
agcuaagagcacacccgucuauguagcaaaauagugggaagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacaccaaaaaucccaaacauaua
acugaacuccucacacccaauuggaccaaucuaucacccuauagaagaac
uaauguuaguauaaguaacaugaaaacauucuccuccgcauaagccugcg
ucagaucacacugacaauuaacagcccaauaucuacaaucaaccaacaag
ucauuauuacccucacugucaacccaacacaggcaugcucauaaggaaag
guuaaaaaaaguaaaaggaacucggcaaaucuuaccccgccuguuuacca
aaaacaucaccucuagcaucaccaguauuagaggcaccgccugcccagug
acacauguuuaacggccgcgguuaaccgugcaaagguagcauaaucacuu
guuccuuaaauagggaccuguaugaauggcuccacgaggguucagcuguc
ucuuacuuuuaaccagugaaauugaccugcccgugaagaggcgggcauaa
cacagcaagacgagaagacccuauggagcuuuaauuuauuaaugcaaaca
guaaccugcauuaaaaauuucgguuggggcgaccucggagcagaacccaa
ccuccgagcaguacaugcuaagacuucaccagucaaagcgaaccucaauu
gauccaauaacuugaccaacggaacaaguuacccuagggauaacagcgca
auccuauucuagaguccauaucaacaauaggguuuacgaccucgauguug
gaucaggacaucccgauggugcagccgcuauuaaagguucguuuguucaa
cgauuaaaguccuacgugaucugaguucagaccggaguaauccaggucgg
uuucuaucuacuuuauuccucccuguacgaaaggacaagagaaauaaggc
cuacuucacaaagcgccuucccccguaaaugauaucaucucaacuuagau
acccacacccaagaacaggguu

<<<.......<<<<....................................
<......>...........<<.....>>........>>.>>.........
....<<....>>......................>>>...........<<
<.......>>>...<.<........>.>.<<<<<<.........<<<.<<
..<<....>>...>>.>>>...<<.<...<<<<.<.....<<<<<.<<<.
.<<<...>>>...<<<..<<<<........>>>>.>>>....>>>.>>>>
>...<<.......>>......>.>>>>......>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>.<.<<<......>
>>.>..<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>.........................
..>...>>>>>>........>>>>>>...<<<<<......>>>>>.....
....>>>>>>.......<<..<<<....>>><<<<..<<<<........<
<<<<......>>>>>......<<<...<<<<...................
....>>>>.......>>>.....<<......>>.>>>>.....>>>>..<
<<<...<<<<<<<<.<<................<<<<<<..<<<......
...>>>...<<<<<<.............>>>>>>....<<<.<<<..<<<
<<....>>>..>>>>><<<<<....>>>>>........<...........
<<<<<<.....>>>>>>.....>....>>>....>>.>>>>........>
>.>>>>>>>>>>>>.>>...........<<<<<........>>>>>....
...<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<<<<<....
......>>>>>>>>>>>>>..<<<<.....>>>><<<<<<..........
.>>>>>>..<<.....<<<..<<<<.....>>>>..>>>....>>.....
....<<<....>>>............>>>>..>>>>>>.......<<<..
<.<<<<<<...<<.......>>...>>>>>>...>.>>.>.......<<<
<<.<<<<<<..<<.<<<<<<......>>>>>>...>>.<<<<<.....>>
>>>.....>>>>>..>...>>>>.>....<<<<<<<....>>>.>>>>..
..>>..>>>.>>..<<<.<<<.................>>>.>>><<<<<
...<<<....>>>.>>>>>......<<<................>>>...
......<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6nu2 Structural insights into unique features of the human mitochondrial ribosome recycling.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): G24 G25 R28 N36 P37 S38 M60 K61 G62 R65 R66
• Binding residue (residue number reindexed from 1): G1 G2 R5 N13 P14 S15 M37 K38 G39 R42 R43

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005762 mitochondrial large ribosomal subunit

External links

• PDB: RCSB:6nu2, PDBe:6nu2, PDBj:6nu2
• PDBsum: 6nu2
• PubMed: 30962385
• UniProt: Q86TS9|RM52_HUMAN Large ribosomal subunit protein mL52 (Gene Name=MRPL52)