Structure of PDB 3jcs Chain j Binding Site BS01

Receptor Information
>3jcs Chain j (length=78) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TKGTTSMGQRHGRTHILCRRCGRNSYHVQWERCAACAYPRASRRRYNWSV
KAIKRRRTGTGRCRYLKVVNRRIANHFK
Ligand information
>3jcs Chain 1 (length=1554) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacuguauuaag
cgaguagcacuguuugggaaugcagugucaaguuggcagguauuugucug
ccaaaguuaaauacagaguaggaagaccgauagcgaacaaguagcgugag
cgaaaguuugaaaagcacuuuggaaagagagugaaauagaaccugaaguc
gugacaaagacaauggaaguaccuccauuucaacggccagaaccagcccu
acugcauuauccugucggccggcgggcaacgaagugcaagaauuuugggu
cuuggugaaugcuccauggcgauggaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggagauauccagu
acuucucucguacugaaagggagaugcaaugcaucuguggugugcacacg
ucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcgu
uggagugugccuguuuggacccgaaagguggugaacuaugccugaacaag
gugaagcccgggaacccagguggaggccuguagcgaugcugacgugcaaa
ucgcucguaugauuuggguaucggagcgaaagacucaucgaaccaccuag
uagcugguucacaucgaaguuucccucaggauagcuggugcuaguagaag
uauugugcgguaaagcaugauuagagguugguguuaauaucgaccuauuc
ucacuuuaaaugugcaaacaaaccugccuuagccugcaaggccggaaaga
aauuagaggcaccaagugggccuucuucgguaagcggagcaggcgaugcg
gaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucga
uacgugaaaaggguguugguggauaacaaauccaccggccccgaaaaugg
augacgcuuaagcccaauuagugauugcccauuauuccuuugguaagggc
ggaaacuuggagaaaguguagcccuuccgauguagauguggccuggaggu
uaggacgaagcuuauggcgugagccuaagauggaccggccucuagugcag
aucuugguuggcguagcaaagaucuaacggagacguuggauacuggagcg
gggaaggauuucgugccaacggcacucguacacgaguuguucggaaacug
agcacaacguuauaucguuuuguuaggaaagugaaggugugggccauaac
ugaaaaggggcaacagagaaccuggguuauauuccaaaaagaaauugcau
gugg
......................<<<<<......<<....>>.......>>
>>.>...<.....<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<...<<<<<<<......>>>>>.>>.....>>>>
....<..<<.<<<<.<...<<<<..<<.<<<<<.......<.........
.<......<..........>.....>..........>............<
<.......>>.....>>>>>...>>....>>>>.>.>>>>.>>.>.....
......<<<<<<<........>>>>>>>......<<<<<........>>>
>>..>>>....>...............................<<....>
>................<<<<....>>>>.....................
.............<<<..<<<<<<.<<<<<.......<....<.<<....
..........<<<..........>>>.................>>.>...
.....<....>.......>......>>>>>>>>>>>..>>>.<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<.<<<<.<<<...>>
>>>.>>>>>...<<....>>.....<.....>.....<<<.......<..
..........>........>>>..<<<<<<<.<.......>.>>>>>.>>
....>>>>>.>>>>>>>..<<.<...<<<<<<.....<<<<<<<<<..<<
<....<<<.<<<..>>>.>>>.....>>>...<<<..<<.<<........
>>>>.>>>....>>>>>>>>>...<<.......>>......>>>>>>...
...>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<.
<.<<<<<<<...<<<..<<<....<<<<<<<<<<..>>>>>>>>>>....
>>>>>>....>>>>>>>.....<<.<<<...<<..>>..>>>.>>.....
.>>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<
<..[...>>>>..<<<<<<<...<<<(((........<<<<<......<.
...]......<<...<<<<<<<<<.....>>>>>>>>>..>>........
..))).>....>>>>>..........>>>...>>>>>>><<<<.<<<<<.
.....................>>>>>>>>>....>>>>>....<<<<<<<
<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>......
..>>>>>>..............<<<<<<<....>>>>>>>..........
..........<<<<<....<<.....>>..>>>>>....<<.........
.<<.<<<<<......>>>>...............<<<<.......>>..>
>......>.>>..........<<<..........>....>>.>>......
....
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3jcs 2.8- angstrom Cryo-EM Structure of the Large Ribosomal Subunit from the Eukaryotic Parasite Leishmania.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		T2 K3 G4 T5 T6 S7 Q10 R11 H12 G13 R14 T15 H16 R24 S26 H28 Q30 R33 A35 A36 R41 A42 S43 R45 R46 Y47 N48 W49 S50 K52 A53 R56 R57 R58 N71
Binding residue
(residue number reindexed from 1)		T1 K2 G3 T4 T5 S6 Q9 R10 H11 G12 R13 T14 H15 R23 S25 H27 Q29 R32 A34 A35 R40 A41 S42 R44 R45 Y46 N47 W48 S49 K51 A52 R55 R56 R57 N70
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3jcs, PDBe:3jcs, PDBj:3jcs
PDBsum3jcs
PubMed27373148
UniProtP62885|RL37_LEIDO Large ribosomal subunit protein eL37 (Gene Name=RPL37)

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