Structure of PDB 7nwh Chain ii Binding Site BS01

Receptor Information
>7nwh Chain ii (length=419) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQISRVAKMLADE
FGTASNIKSRVNRLSVLGAITSVQQRLKLYNKVPPNGLVVYCGTIVTEEG
KEKKVNIDFEPFKPINTSLYLCDNKFHTEALTALLSDDSKFGFIVIDGSG
ALFGTLQGNTREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRKV
AETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQRLQSKVLKLVD
ISYGGENGFNQAIELSTEVLSNVKFIQEKKLIGRYFDEISQDTGKYCFGV
EDTLKALEMGAVEILIVYENLDIMRYVLHCQGTEEEKILYLTPEQEKDKS
HFTDKETGQEHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVKG
FGGIGGILRYRVDFQGMEY
Ligand information
Receptor-Ligand Complex Structure
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PDB7nwh Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
Resolution4.1 Å
Binding residue
(original residue number in PDB)		D54 G57 T58 N61
Binding residue
(residue number reindexed from 1)		D49 G52 T53 N56
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003747 translation release factor activity
GO:0004045 aminoacyl-tRNA hydrolase activity
GO:0008079 translation termination factor activity
GO:0016149 translation release factor activity, codon specific
GO:1990825 sequence-specific mRNA binding
Biological Process
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0002184 cytoplasmic translational termination
GO:0006412 translation
GO:0006415 translational termination
GO:0006449 regulation of translational termination
GO:0006479 protein methylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0018444 translation release factor complex
GO:0022626 cytosolic ribosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7nwh, PDBe:7nwh, PDBj:7nwh
PDBsum7nwh
PubMed34157102
UniProtP62497|ERF1_RABIT Eukaryotic peptide chain release factor subunit 1 (Gene Name=ETF1)

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