Structure of PDB 7oya Chain i2 Binding Site BS01

Receptor Information

>7oya Chain i2 (length=36) Species: 7955 (Danio rerio)

KREFERHSGSDRSSVRSEEKRSGSGSRNWGSVRDHM

Ligand information

>7oya Chain 22 (length=1531)

uaccugguugauccugccaguaauauaugcuugucucaaagauuaagcca
ugcaagucuaagugcacacgagugaaacugcgaauggcucauuaaaucag
uuaugguuccuuugaucacuuggauaacuguggcaauuccagagcuaaua
caugcgcgccgagacgcgugcauuuaucaguggugacucuagauaaccuc
gggccgaucgcgcgccggcggcgacgguucauucgaaugucugcccuauc
aacuuucgaugguagguccgucgccuaccauggugaccacgggugacggg
gaaucaggguucgauuccggagagggagccugagaaacggcuaccacauc
caaggaaggcagcaggcgcgcaaauuacccauuuccgacacggagaggua
gugacgaaaaauaacaaugaauuggaaugagugcaucccaaacccauggg
cgaggacccauuggagggcaagucuggugccagcagccgcgguaauucca
gcuccaauagcguaugcuaacguugcugcaguuaaaaagcucguaguugg
aucucuacuuugaaaaaauuagaguguucaaggcagggccccccauugaa
uaccccagcuaggaauaauggaauaggaccccggggccaugaucgagagg
gacggccgggggcauucguauugcgccgcuagaggugaaauucuuggacc
ggcgcaagacggaccggagcgaaagcguuugccaagaacguuuucauuaa
ucaagaacgaaagucggagguucgaagacgaucagauaccgucguaguuc
cgaccguaaacgaugccgacccgcgauccggcggcguuugacccgccggg
cagcguugcgggaaaccacgagucucugggcuccggggggaguaugguug
caaagcugaaacuuaaaggaauugacggaagggcaccaccaggaguggag
ccugcggcuuaauuugacucaacacggggaaccucacccggcccggacac
ggaaaggauugacagauugacggcucuuucucgauucugugggugguggu
gcauggccguucguaguugguggagcgauuugucugguugauuccgauaa
cgaacgagacucuggcaugcuaacuaguuacgcggccgucggcguaacuu
cuuagagggacaaguggcguucagccacgcgagacugagcaauaacaggu
cugugaugcccuuagauguccggggcugcacgcgcgccacaaugggcgga
ucaacguguccugcgccgacaggcgcggguaacccguugaaccccgcccg
ugauggggaccgauugaaacuauuucccgagaacgaggaauucccaguaa
gcgcaggucaucagcuugcguugauuaagucccugcccuuuguacacacc
gcccgucgcuacuaccgauugagcggcucagugagguccucggaucgcga
gaagacgaucgaacucggucguuuagaggaaguaaaagucguaacaaggu
uuccguaggugaaccugcggaaggaucauua

...<<<<<.[.((((>>>>><<.<<<<<<<...<.<<..<......<<<.
<<<..<<....<<.............>>.>>......<<........<<<
.<<<..<<....<<<.....<<.....<<.<<<.....>>>.>>......
>>....<<<......>>>.<<..<<<<<...<......>..>>>>>....
..>>...<<<<.<<<..>>>>>>>....>>>...>>>>>.>>>.<<<...
.<<<....<<<<<<<<.......>>>>>>>>>>>......>>>...<<<.
<<<<....>>>>....>>>.>>.<<.<<<..........>>>.>>.<.<<
....>>.>...>>>>>>.........<<<....<<<<...>>>>..>>>.
.>...>>.>.....<<<....>>>......<<.<<<.........>>>.>
>.........<<<<<((......<<<<.....<<..))>>.......>>>
>.>>>>>..>>>>>>>.>>.........<.<((.....<.<<...<<<.<
<....<<<<<.<.......<<...<.......>...<<....>>......
>>......>.>>>..>>.........<.<<<..>>>.>....>>....<<
<<<<..<...<<<<..<<..<<<<<<<<...<<<......>>>......>
>>>>>>>..>>.......<<....>>...>>>>..>..>>>.>>>...>>
>...>>.>....<<<<<<<...<...<<<<.<.....>.>>>>...>>>>
>>>>..........<<<.<<.<<<..<<<<<<<<.<<<.>>>>>>>>>>>
..>>>....<<..))>>....>>.....>>>.>.>.<<<......<<<..
....>>>....>>>..)))).]<<<<<.<<<<<<...<...<<<<<...<
<.<<<<<<......<<........>>..........<<<<<.<.......
.<........<<..<<........>>..>>.......>....<.<<.<<<
..<<.<<<<<<....<<<.<<<<<....>>>...<<<......>>>...>
>.>>>....<<<.......<<<<..<<<<<<<<<<<.>>>.>>>>>>>>.
.>>>>........<<<<<.....>>>>>........>>>....>>>.>>>
.....>>>>>>>>....>.>>>>>...>>.>>>>.>>......<<<<<<.
.......<.<<<<<<<<....>>>>>>>>....>.........>>>>>>.
..........<<<...........>>..>..........>>>>>.....<
<<<<<<<.......>>>>>>>>.......>....>>>>>>>>>.>>....
<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<..>>
...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...>.>>...>.....
<<<<<<<<<<..>>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oya A molecular network of conserved factors keeps ribosomes dormant in the egg.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): K187 F190 E191 R192 R198 S199 V201 R202 K206 R207 S210 G211 R213
• Binding residue (residue number reindexed from 1): K1 F4 E5 R6 R12 S13 V15 R16 K20 R21 S24 G25 R27

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0043022 ribosome binding
• GO:0061770 translation elongation factor binding

Biological Process

• GO:0006417 regulation of translation
• GO:0033120 positive regulation of RNA splicing
• GO:0045948 positive regulation of translational initiation
• GO:0141014 ribosome hibernation

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0010494 cytoplasmic stress granule
• GO:0015030 Cajal body
• GO:0016607 nuclear speck

External links

• PDB: RCSB:7oya, PDBe:7oya, PDBj:7oya
• PDBsum: 7oya
• PubMed: 36653451
• UniProt: Q5XJA5|HABP4_DANRE Intracellular hyaluronan-binding protein 4 (Gene Name=habp4)