Structure of PDB 7oyc Chain i1 Binding Site BS01

Receptor Information

>7oyc Chain i1 (length=98) Species: 8355 (Xenopus laevis)

IRYPMAVGLNKGHRVTKNVTKPRHCRRRGRLTKHTKFVRDMIREVCGFAP
YERRAMELLKVSKDKRALKFIKKRIGTHIRAKRKREELSNVLAAMRKA

Ligand information

>7oyc Chain 51 (length=3245)

ucagaccucagaucagacgcggcgacccgcugaauuuaagcauauuacua
agcggaggaaaagaaacuaaccaggauucccccaguaacggcgagugaag
agggaagagcccagcgccgaauccccgcccgcgggcgcgggacguguggc
guacgggagaccggacccccccggcgcgcgggggcccaaguccuucugau
cgaggcccagcccgcggacgguguuaggccgguggcggcccccggcgcgg
cgggacccggucuccucggagucggguuguuugggaaugcagcccaaagc
gggugguaaacuccaucuaaggcuaaauaccggcacgagaccgauagcgg
acaaguaccguaagggaaaguugaaaagaacuuugaagagagaguucaag
agggcgugaaaccguuaagagguaaacgggugggguccgugcgguccgcc
cggaggauucaacccggcggguccgccggccggaccgggccacucggcgg
gacgcggcccgggcggccccggcgcccgcagggcgcauuuccuccgcggc
ggugcgccgcgaccggcuccgggccggcugggaaggcccagggguucagg
ggaguuacagcccccccccaggcagcaucgccgucgcccggggccgaggg
uccgcggccuccuccccaagggggaaggggccccccgcucccggcgcggc
gcggacugcccccagugcgcgccgcgccgccgaggcgggagggcccgcgg
gagccgccagggguccgcggcgaugucggugucccacccgacccgucuug
aaacacggaccaaggagucuaacgcgcgcgcgagucggagggacgcgaaa
cccuguggcgcaaugaaggugagggccggggcgccccggcugagguggga
ucccgccgcgccggcgggcgcaccaccggcccgucucgcccgccccgucg
gggagguggagcgugagcgcgcgcgauaggacccgaaagauggugaacua
ugccugggcagggcgaagccagaggaaacucugguggagguccguagcgg
uccugacgugcaaaucggucguccgaccuggguauaggggcgaaagacua
aucgaaccaucuaguagcugguucccuccgaaguuucccucaggauagcu
ggcgcucguccgucgcaguuuuauccgguaaagcgaaugauuagagguac
cuauucucaaacuuuaaauggguaagaagcccggcucgcuggcuuggagc
cgggcguggaaugcgagcacgccuagugggccacuuuugguaagcagaac
uggcgcugcgggaugaaccgaacgccggguuaaggcgcccgaugccgacg
cucaucagaccccagaaaagguguugguugauauagacagcgccgaauca
acuagcccugaaaauggauggcgcuggagcgucgggcccauacccggccg
ucgccggcgcugggcuaggccgcgacgaguaggagggccgccgcgguggg
cgcggaagccccgggcgagggcccggguggagccgccgcgggugcagauc
uuggugguaguagcaaauauucaaacgagaacuuugaaggccgaagugga
gaaggguuccaugugaacagcaguugaacaugggucagucgguccuaaga
gaugggcgagcgccguucggaagggcggccgaucgaaagggagucggguu
cagauccccgaacccggagcggagacgggcguccagugcggcgacgcgac
cgaucccggagaagccggcgggagccccggggagaguucucuuuucuuug
ugaagggcagggccgcccuggaauggguucgccccgagagaggggcccgc
gccuuggaaagcgucgcgggcggcguccggugagcucucgcuggcccuug
aaaauccgggggagaggguguaaaucucgcgccgggccguacccauaucc
gcagcaggucuccaaggugaacagccucuggcauguuagaacaauguagg
uaagggaagucggcaagucagauccguaacuucgggauaaggauuggcuc
uaagggcuggcagcugacuuagaacuggugcggaccaggggaauccgacu
guuuaauuaaaacaaagcaucgcgaaggcccgaggcggguguugacgcga
ugugauuucugcccagugcucugagucaaagugaagaaauucaaugaagc
gcggguaaacggcaagguagccaaaugccucgucaucuaauuagugacgc
gcaugaauggaugaacgagauucccacugucccuaccuacuaucuagcga
aaccacagccaagggaacgggcuuggcggaaucagcggggaaagaagacc
cuguugagcuugacucuagucugcaacugugaaguuucacuuacccggug
aggcggggggcuucuggacccaagcgcccggcgggcgcgacccgcuccga
ggacaguggcagguggggaguuugacuggggcgguacaccugucaaaccg
uaacgcagguguccuaaggcgagcucagggaggacagaaaccucccgugg
agcagaagggcaaaagcucgcuugaucuugauuuucaguaugaauacaga
ccgugaaagcggggccucacgauccuucugacuuuuuggguuuuaagcag
gaggugucagaaaaguuaccacagggauaacuggcuuguggcggccaagc
guucauagcgacgucgcuuuuugauccuucgaugucggcucuuccuauca
uugugaagcagaauucaccaagcguuggauuguucacccacuaauaggga
acgugagcuggguuuagaccgucgugagacagguuaguuuuacccuacug
augauguguugucgcaauaguaauccugcucaguacgagaggaaccgcag
guucagacauuugguguaugugcuuggcugaggagccaauggggcgaagc
uaccaucugugggauuaugacugaacgccucuaagucagaauccccccua
aacgugacgauaagcgccgcggagccucggucggccucggauagccggcg
cgccggcgggcagagccgcucgccucgggaccggagcgcggacgaaaggg
ggccgccucucucccggagcgcaccgcacguucguggggaaccuggugcu
aaaucauucguagacgaccugauucugggucaggguuucgugcguagcag
agcagcgcugcgaucuauugaaagucaucccuugagccauuuugu

.........................<<<<<<.....<......>......
>>>>>.>.........<<....>>..<<<<<......<<.....>>....
.>>>>>..<<<..<<<<<...<<<<<<<<<..>>>>>.>>>>.....>>>
>>..<<<<<<<<<......<<<<.<<<<<<<<<<<<.....<<<<.....
.>>>>.....((......<<<.....))>>>.....>>>>>>>>.>>>>.
>>>>...>>>>>>>>>.......<<<<<<<........>>>>>>>.....
<<<<<..((((((>>>>>..>>>...........................
.......<<....>>...............<<<......>>>........
..........................<<<<<<<<..<<<.......<<<<
.<<<<<<.....<<<.<<<<<<...<.<<.......<<.....<<.....
>>.....>>........>>.>..>>>>>>.>>>......>>>>>>..>>>
>.....<...<.<.<.<<<.<<.<.<....<<........<<<<......
............>>>>...........>>.>.>...>>.>>>.>.>....
...<<<<<.<<<<<<....>>>>>>.<<<<<<<<<<<<<..<<<<<<<<<
<<<.<<<<....>>>>.>>>>>>>>>>>>....>>>>>>.>>>>>>.>..
..>>>>>......>....>.......>>>...>>>>>>>>..<<<<....
....>>>><<<<<<....<<<.<<<<<<<<<..<<<..<<<<........
>>>>..>>>...<<....>>...<<<<<<<....>>>>>>>..<<<<<..
.<<<<<<<...>>>>>>>....>>>>>.<<<<<<<<<.<<<<......>>
>>>>>>>>>.>>....>>>>>>>>>.>>>..<<.<..<<<<<<<.....<
<<<<<<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<.
.<<.<<........>>>>.>>>....>>>>>>>>>...<<.......>>.
.....>>>>>>...>..>.>>..<<<<<<....<.<<<....>>>.><<.
<<<<<<<.......<<<.<<<<<<<<<...<<<....<<<....<<<..>
>>....>>>..>>.>...>>>>>>>...<<<<<<<<<.........>>>>
>>>>>....>>>>>>>>>..>>>..>>..<<<<.<<<<<.....>>>>>.
>>>>....<<<......>>>...<<<<<<<...<<<(((.......<<<<
<.....<<..........<<<.<<<<<<<<<<.......<..>...>>>>
>>>>>>>>>..........))).>>...>>>>>..>>>...>>>>>>><<
<<<<.<<<..........>>>>>>>>>....>>>>>>...<<<<<<<<.<
<......<<<<.<<<<....>>>>>>>>...>>>>>>>>>>........>
>>>>><<.....<<.....<<<<<<.......>>>>>>.<<<.....<<<
<<.<<...<<<<<<...<<.....>>.>>>>>>....((<<<<<<...<<
....<<<....>>>..................>>....>>...<<<<<..
......>>>>>))<<<<.<<<<....<<<..>>>...<<<....>>>...
<..<<<<<<<...<<<<<<<<<<<<.<<<<<<<<<<..[[[..>>>>>>.
...<<<<<.<<<<..<<<<.....<<<.....>>>.....>>>>>>>>..
>>>>>.....<<<<<<<..>>>>>>>>>>>...>>>>>>>>>>>>.....
....>>>>>>>..>..........>..>>>.>>>>>>>>..>>.....<<
......>>>>>>>.<<<<.....>>>>..>>>....<<<<.....<<<<<
<<.<<.........<.....<<<<<...............>>>>><<.<<
<<<<<<<<<.>>>>>..>>>>>>.>>............<<<<<<<<<..<
<<.........>>>..<<<<<<<....<<<<.....>>>>......>>>>
>>>...<<...<<..<<<<<<.<.<<.....<<<<....>>>>.....>>
.>>>>>..>>>>.......<...........<<<<<.......>>>>>..
...>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>>>>>..
..>>....<<<<<........>>>>>....<<<<<..<<<.<<......<
<<<.<<<<<<..<<<<<.<<<<<<.<<.<<<<<..>>>>>...<.<<<..
...<<<<................<<<<<<<.>>>>>>>..>>>>..>>>.
>....>>.>>>>>>..>>>>>...<<<.....>>>..<<<<<<.......
....>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>....
.<<.[.(((>>....>>>>>>>...<<<..<<<<.......>>>>..>>>
<<<<....>>>>>>)))].....<<<<<<<...<<..)))))).>>.>>>
>>>>.........>>>>..>>>>>>.......<<.<...<<<<<<...<<
.......>>...>>>>>>....>.>.>.......<.<<<.<<<<<<..<.
<.<<<<<......>>>>>...>.>.<<<.........>>>.....>>>>>
..>...>>>..>....<<<<<<<....>>>.>>>>....>>..>>>.>>>
>>.....<<<<<<<<..<<<....<<<<<.................>>>>
>..<<<<....<<<<....<<.<<<<<<<]]].>>>>>..>>.>>...>>
>>...>>>>.<<<....<<<<<...........>>>>>....>>>..>>>
...>>>>>>>>.<<<<<<<..<..<<<.....<<<........<<<<<<.
.>>>>>>.......>>>...<<<...<<<<...<<<.<<<<.........
..>>>>>>>..>>>>...>>>...............>>>..>.>>>>>>>
<<<...<.............>....<<<.<<<<<<.<<.....<<<<...
.<<<<..>>>>...>>>>....>>....>>>.>>>.>>>.>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oyc A molecular network of conserved factors keeps ribosomes dormant in the egg.
• Resolution: 2.4 Å
• Binding residue (original residue number in PDB): G14 H15 V17 R25 H26 C27 R28 R29 R30 G31 L33 T34 K35 H36 R41 Y53 K67 R68 K71 R76 G78 T79 R82 K84 R85 K86
• Binding residue (residue number reindexed from 1): G12 H13 V15 R23 H24 C25 R26 R27 R28 G29 L31 T32 K33 H34 R39 Y51 K65 R66 K69 R74 G76 T77 R80 K82 R83 K84

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7oyc, PDBe:7oyc, PDBj:7oyc
• PDBsum: 7oyc
• PubMed: 36653451
• UniProt: Q66KU4|RL36_XENLA Large ribosomal subunit protein eL36 (Gene Name=rpl36)