Structure of PDB 8fru Chain i Binding Site BS01

Receptor Information
>8fru Chain i (length=83) Species: 941442 (Giardia intestinalis assemblage A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGKVFNLKKGGAVVRIVRKKPHQEFVKSIIQECTGMAPYEMHIIELLRMN
KDRHALRYAKKRLGNIKRAKAKRDQLSVYARNI
Ligand information
>8fru Chain 1 (length=2551) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguac
gccccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcgg
gaggagcccgccccgaaggcgcgcuguggggcgcaccgccgcgagggggc
ccgagggccccgcccgagagggugcaagccccguacggcgggcggcgagu
agcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcu
aaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacgguga
aaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccgg
cccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcg
agcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccg
ccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaa
aggcggugaucuaugcccggcgagggcgaggccgggcgaaagccuggugg
aggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugg
gggcgaaagacucaucgaaccgccugguagcugguugccuccgaaauguc
ucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccgg
cgggagcggggccucgcccgccccccaaacuccgaagggccgcgccgccc
cgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccu
ccugguaagcaggacgggcgaggcgggacgauccggacgccgggccaggg
ugcgccgccggggcccgcggaacggcgucggccggucccgacagcagccg
aaucggccggcccggaaaauggagcgcgccggagccccggacccgcgccc
ggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaagg
cggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcag
uagccgcuacuccgcgccccggaggacugagggggagacggguuccgcgg
cgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagacc
gggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggc
aggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggac
cgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgcc
uugcgcggagaggggggcccgggggcggaccccgcgcguccccggccgcc
ccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcagga
cuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagu
cggcaagccggcuccguaaccucgggaaaaggaguggcucugacggccgg
gucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacag
cgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagug
ccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcggg
aguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuucc
gacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuc
cgcgagccuccagccucgggaacgggcgagggccggccagcggggcaaga
agacccuuuugagcuugacuccagcccgggccuguggggcgggggccgcc
gccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucg
gcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggc
ucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccg
acccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauc
cuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagg
gauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugau
ccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgu
cggauuguucacccguucaagggaucgugagcuggguuuagaccgucgug
agacagguuaguuuuacccuacuggccccggggccagagcacggcgggcc
aguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggc
cgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucua
agcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgug
ccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuc
cuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcg
c
........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<....<<.....>>.....>>
>>>..[[[...<<<.............>>><<...<<<<<<....<<<<<
......>>>>>((......<<<.....))>>>...>>>>>>>>.......
.<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]].
.................................<<....>>.........
.......<<<....>>>............................<<<<<
<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<.
.<<<...<<<....>>>..>>>...<<....>>............<<<<<
<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..
<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>..
...>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>..
.<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<
<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<
<<<..<<<<<..>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<
<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<
<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<
<(((...<<<<<<<........<<<.<<<<<<<<<...............
..>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>
>>><<<<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<
<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<...
..<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<
...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>
......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>
))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<
<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.
....>>......>>>>>>...>>>>>>....>>>>>.>>>>>>>..>>>.
........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.
>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.....
....<.....<<<<<....<<..>>.....>>>>><<.<<<<<<......
>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<
<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<
<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<
<<<.......>>>>>>........<...........<<<<<<.....>>>
>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>
>>>....>>....<<<<<........>>>>>...((((((..{{{.....
....{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<........
.>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...
<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<
...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>..
.<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......
(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}
.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>
.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.
<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<...
.>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<.
..............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}
.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........
>>>>>>...>>>..>>>..>>>>>....<<<<<<................
............>>>>>>.....<<<<<.......>>>>..<<<<<<<<<
<<....<<<<.<..<<...>>..>>>>>...>>>>.>>>>>.>>...>..
.
Receptor-Ligand Complex Structure
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PDB8fru The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function.
Resolution2.49 Å
Binding residue
(original residue number in PDB)
P2 G3 K4 V5 K10 V14 R19 K27 H29 Y46 R60 H61 R64 R69 G71
Binding residue
(residue number reindexed from 1)
P1 G2 K3 V4 K9 V13 R18 K20 H22 Y39 R53 H54 R57 R62 G64
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8fru, PDBe:8fru, PDBj:8fru
PDBsum8fru
PubMed38242118
UniProtA8BYA6

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