Structure of PDB 8eug Chain i Binding Site BS01

Receptor Information

>8eug Chain i (length=96) Species: 4896 (Schizosaccharomyces pombe)

APGLVVGLNKGKTLTKRQLPERPSRRKGHLSKRTAFVRSIVREVAGFAPY
ERRVMELIRNSQDKRARKLAKKRLGTLKRAKGKIEELTSVIQSSRL

Ligand information

>8eug Chain 1 (length=2869)

uugaccucaaaucagguaggacuacgcgcugaacuuaagcauaucaauaa
gcgcaggaaaagaaaauaaccaugauucccucaguaacggcgagugaagc
gggaaaagcucaaauuugaaaucuggcaacauuucuuuuguuguccgagu
uguaauuucaagaagcugcuuugaguguagacgaucggucuaaguuccuu
ggaacaggacgucagagagggugagaaccccgucuuuggucgauuggaua
ugccauauaaagcgcuuucgaagagucgaguuguuugggaaugcagcucu
aaaugggugguaaauuucaucuaaagcuaaauauuggcgagagaccgaua
gcgaacaaguagagugaucgaaagaugaaaagaacuuugaaaagagaguu
aaauaguacgugaaauugcugaaagggaagcauuggaaaucagucuuacg
uaggucagcaucaguuuucgggggcggaaaaagaauaagggaagguggcu
guuuauagcccuuguuguaauacguccacuggggacugaggacugcggcu
ugccaaggaugcugacauaaugguuuucaauggcccgucuugaaacacgg
accaaggagucuagcaucuaugcgaguguuugggugaaaaacccauccgc
gaaaugaaagugaaugcaggugggaacgcccuggcgugcaccaucgaccg
acccggaaguuugucaauggaaggguuugaguaagagcauagcuguuggg
acccgaaagauggugaacuaugccugaauagggugaagccagaggaaacu
cugguggaggcucguagagauucugacgugcaaaucgaucuucaaauuug
gguauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccg
aaguuucccucaggauagcagaaacucagaucaguuuuaugagguaaagc
gaaugauuagagguaccuauucucaaacuuuaaauauguaagacgcccuu
gucgcuuaauuggacgugggccaucgaaugagaguuucuagugggccauu
uuugguaagcagaacuggcgaugcgggaugaaccgaacgugagguuaagg
ugccggaauguacgcucaucagacaccagaaaagguguuaguucgaacua
gcccugaaaauggauggcgcuuaagcguacuacccauaccucaccgucug
gguuaagaagcucagacgaguaggcaggcguggagguuugugacgaagcc
uugggcgugagccugggucgaacagccucuagugcagaucuugguggaag
uagcaaauauucaaaugagaacuuugaagacugaaguggggaaagguucc
augugaacagcaguuggacauggguuagucgauccuaagagauagggaag
cuccguaugaaaggcacgauuuuucgugccuaucgaaagggaauccgguu
aauauuccggaaccagaagguggaaucaacacggcaacguaaaugaaguu
ggagacgucggcgggagcccugggaagaguucucuuuucuuuuuaacaaa
ccacacccugaaaucgguuuauccggagcuaggguaugguguuuggaaga
guucagcggcugaauccggugcgcucucgacggcccuugaaaauccaacg
gaaguuguuuucacaucuggucguacucauaaccgcagcaggucuccaag
gugaacagccucuaguugauagaacaauguagauaagggaagucggcaaa
auggauccguaacuucgggauaaggauuggcucuaaggguaucaacuuag
aacugguacggacaaggggaaucugacugucuaauuaaaacauagcauug
cgauggccagaaagugguguugacgcaaugugauuucugcccagugcucg
aaugucaaagugaagaaauucaaccaagcgcggguaaacggcaagguagc
caaaugccucgucaucuaacuagugacgcgcaugaauggauuaacgagau
ucccacugucccuaucuacuaucuagcgaaaccacagccuggggaacggg
ccaggcaaaaucagcggggaaagaagacccuguugagcuugacucuaguu
ugacauugugaauuuacuuaaucaaugaagcggaauuucuagcguuaaag
uuucgcgaacugauccgcguugaugacauugucagguggggaguuuggcu
ggggcggcacaucuguuaaaagauaacgcagguguccuaagggggacuca
ucgagaaucucgaguagaauaaaaggguaaaaguccccuugauuuugauu
uucagugugaauacaaaccaugaaaguguggccuaucgauccuuuguucc
cucgaaauuugaggacagaggugccagaaaaguuaccacagggauaacug
gcuucagccaagacguugcauucuucgaugucggcucuuccuaucauacc
gaauucgguaagcguuggauuguucacccacuaauagggaacgugagcug
gguuuagaccgucgugagacagguuaguuuuacccuacugaugaaguguc
gucgcaaugguaauucaacuuaguacgggaaccguugauucagaucauug
guauuugcggcugccugacaaggcaaugccgcggagcuaucaucugccgg
auaacggcugagccagaauccgugccagaaagcgacgauuuauguauaaa
aauagagguaacucuccuguaucguagaagaugggcgaugguugaacgga
aguguuuugacuuguccaugaaauuccagaauccauugcauacgacuuua
auguggaacgggguauuguaagcaguagagucgaucugcugagauuaagc
cuuuguucccaagauuugu

........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<......<<.....>>.....
>>>>>..<<<...........<<.<<<<<<<.......>>>>>>>.>>..
...........<<<<<.<<<<<..<<<<<..<<<<<<<<<.....<<<<.
.....>>>>.((......<<<.....))>>>......>>>>>>>>>..>>
>>>.....>>>>>>>>.>>........<<<<<<<........>>>>>>>.
....<<<<<..((((((>>>>>..>>>.......................
...........<<....>>...............<<<<....>>>>....
..............................<<<<<<<<<<<.<...<<..
>>.<<<<<<<.<<<<<<<<<<<<<<<.....<.<<<<<<<<......<..
.>......>>>>>>>>....>.>>>>>.>>>>>>>>>>........<<<.
.>>>.....>>>>>>>....>>>>>>>>>>>>..<<<<........>>>>
<<<<<<....<<<<<<.<<<<<<..<<<...<<<<.....>>>>...>>>
...<<....>>.......<<<<<..<<<<<..>>>>>...>>>>>.<<<<
<<<<....<<<....>>>....>>>.>>>.>>....>>>>>>.>>>>>>.
.<<.<...<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>
>>>>>.....>>>...<<<..<<.<<........>>>>.>>>....>>>>
>>>>>...<<.......>>......>>>>>>......>.>>..<<<<<<.
...<.<<<....>>>.><<<<<<<<<<...<<<.<<<<<<<.....<<<.
...<<<....<<<..>>>....>>>..>.>>.....>>>>>...<<<<.<
<<<.<......>>>>>.>>>>.....>>>>>>>>>>>>>.>>..<<<<.<
<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<...<<
<(((.....<<<<<<.....<<..........<<<.<<<<<<<..>>>>>
>>>>>..........))).>>...>>>>>>.>>>...>>>>>>><<<<<<
<<<......>>>>>>>>>....>>>>>>..<<<<<<<<.<<......<<<
<.<<<<....>>>>>>>>...>>>>>>>>>>........>>>>>><<...
..<<.....<<<<<<.......>>>>>><<<<.....<<<<<.<<...<<
<<<<...<<.....>>.>>>>>>....((<<<<<<...<<....<<<...
.>>>........<<<<<<......>>>>>>..>>....>>...<<<<<..
......>>>>>))<<<<..<<<<<<<....<<<....>>>.....((<<<
<<<...<<<<.<<<<<<<.<<<<<<<<<<...[[..>>>>>>....<<<<
<...<<<<<<....<<<.....>>>....>>>>>>.....>>>>>.....
<<<<<<<.>>>>>>>>>>>...>>>>>>>.>>>>.........>>>>>>.
......>>>>.>>>.>>>>>>>>..>>.....<<......>>>>>>>.<<
<<.....>>>>..>>>>..<<<<.....<<<<<<<.<<............
...<<<<<...............>>>>><<.<<<<<<<<..>>..>>>>>
>.>>............<<<<<<<<<..<<<.........>>>..<<<<<<
<....<<<<.....>>>>......>>>>>>>...<<...<<..<<<<<<<
..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>.......<.
..........<<<<<.......>>>>>.....>.....>>....>>.>>>
>>>>.....>>.>>>>>>>..>>>>>>....>>....<<<<<........
>>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<
<<<<<..<<<<..>>>>...<<<<<.....<<<<..........))..<<
<<<...>>>>>..>>>>..>>>>>.....>>>>>>>>..>>>>>...<<<
.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<...
<<<<<<.>>>>>>.....<<...(((>>....>>>>>>>...<<<..<<<
<.......>>>>..>>>.<<<....>>>.>>)))......<<<<<<<..<
<<<.))))))>>>>>>>>>>>.........>>>>..>>>>>>.......<
<...<<<<......>>>>..>.>.......<<<<<.<<<<<<..<.<<<<
<<..>>>>>>...>.<<<.........>>>.....>>>>>..>...>>>.
>>....<<<<<<<....>>>.>>>>....>>..>>>.>>>>>.....<<<
<<<<<..<<<<...<<<<<..............>>>>>..<<<<<...<<
<<....<<<<<<<<<<]]..>>>>>..>>>>>...>>>>..>>>>>.<<<
<....<<<<.>>>>....>>>>.>>>>....>>>>>>>>......<<...
....<<<<....>>>>....>>........<<<<<....<<<<.<<<...
...>>>..>>>>..>>>>>.........<<<<<.<.............>.
....<<<<<<<<<.<<<....<<<<....<.>...>>>>...>>>....>
>>>.>>>>>...>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 8eug Chromatin localization of nucleophosmin organizes ribosome biogenesis.
• Resolution: 2.8 Å
• Binding residue (original residue number in PDB): G12 K13 L15 R23 P24 S25 R26 R27 K28 G29 H30 L31 S32 K33 R34 T35 R39 Y51 K65 K72 K73 R74 L75 G76 T77 L78 R80 K82 K84
• Binding residue (residue number reindexed from 1): G11 K12 L14 R22 P23 S24 R25 R26 K27 G28 H29 L30 S31 K32 R33 T34 R38 Y50 K64 K71 K72 R73 L74 G75 T76 L77 R79 K81 K83

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:8eug, PDBe:8eug, PDBj:8eug
• PDBsum: 8eug
• PubMed: 36423630
• UniProt: O94658|RL36B_SCHPO Large ribosomal subunit protein eL36B (Gene Name=rpl3602)