Structure of PDB 8a98 Chain i Binding Site BS01

Receptor Information
>8a98 Chain i (length=95) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APTPRTGIIAGFNKGHVTTRRPRQPSPNDRVPHKHLRAVKAIIADLVGLS
PLEKRVQEFLRVGKEKRALKYCKKRLGDFTAAKKKRSKMEEALRH
Ligand information
>8a98 Chain 1 (length=1579) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuuaaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguuggcagguauuugucugccaaag
uuaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaag
uuugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugaca
aagacaauggaaguaccuccauuucaagagccagaaccagcccuacugca
uuauccugucgggggucaaaauccggcgggcaacgaagugcaagaggguc
uuggugaaaugagcggaguauuugagcuggcacgggcacgcacucuucuc
cgugaugcuccauguuggcgauggaaauggggugcccccacccgucuuga
aacacggaccaaggagucaaacagacgcgcaagggaggagauauggccag
uacuucucucguacugaaagggagaugcaaaaugcaucuguggugugcac
acgucaaauccguuugauuugcccaacaccgaccggcccuccguggguug
cguuggagugugccuguuuggacccgaaagguggugaacuaugccugaac
aaggugaagcccggggaaacccagguggaggccuguagcgaugcugacgu
gcaaaucgcucguaugauuuggguaucggagcgaaagacucaucgaacca
ccuaguagcugguucacaucgaaguuucccucaggauagcuggugcuagu
agaaguauugugcgguaaagcgauacuuuaaaugugcaaacaaaccggcc
uuagccaacugcaaggccggaaagaaaagaauuagaggcaccaagugggc
cuucuucgguaagcggagcaggcgaugcggaaugaaccgcuuagggauau
guggcgucaaaacuuaugggcucauucucgauacguaaaggguguuggug
gccaccggccccgaaaauggaugacgcuuaaggccaauuagugaaugccc
auuauuccuuugguaagggcggaaacggagaaaguguagcccuuccgaug
uagauguggccuggagguuaggacgaagcuuauggcgugagccuaagaug
gaccggccucuagugcagaucuugguuggcguagcaaagaucuaacggag
auauacucaacaugcaacguuggauacuggagcggggaaggauuucgugc
caacggcacucguacacgaguuguucggaaacugagcacaacguuauauc
guuuuguuaggaaagugaaguacugaaaaggggcaacagagaaccuggga
uuauauuccaaaaagaaauugcauguggg
......................<<<<<......<<....>>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<.<<<<<......>>>>>..>....>>>>>
..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........
<<<<<<<........>>>>>>>......<<<<<........>>>>>..>>
>....................................<<....>>.....
...........<<<<....>>>>...........................
.......(((..<<<<<<.<<<<<.....<<<<<.<<<<<<<<<...<<<
<<..<<<<<<<<<........>>>>>>>>>.....>>.>>>...>>>>>.
.>>>>........<<<<<.....<<....<<.<..>...>>..>>..>>>
>>.....<<<<...>>>>>.....>>>>>>>>>>>..))).<<<<.....
...>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........
.>>>..>>>>...<<....>>..<<<<<.....>>>>>...<<<<<...<
<.<<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>
.>>>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<.
.<<<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<...
.....>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>
>>...>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<...
..<<...<<<<<<<...<<<.....>>.>...>>>>>>>.....<<<<<<
<<.<<.....>>>>>>>>>>...........>>...>>>>>>>.>>..<<
<<.<<<<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<.
..<<<<<<......[..((.(........(.........<<<.<<<<<<<
..>>>>>>>>>>..........>>>.)....).)).].........>>>.
..>>>>>>>((((.<<<<<.......>>>>.........>>>>>))))..
..>>>>>..<.<<<<<<<<........<<<<..<<<....>>>.>>>.>.
....>>>>>>>>..>.....>>>>>>..............<<<<<<<...
.................>>>>>>>....................<<<<<.
...<<.....>>..>>>>>....<<..........<<.<<<<<......>
>>>...............<....>......>.>>..........<<<<..
.......>>....>>.>>...........
Receptor-Ligand Complex Structure
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PDB8a98 CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : snoRNA MUTANT
Resolution2.46 Å
Binding residue
(original residue number in PDB)		G17 H18 T20 S28 P29 N30 D31 R32 V35 H37 H39 L40 K44 L80 K87
Binding residue
(residue number reindexed from 1)		G15 H16 T18 S26 P27 N28 D29 R30 V31 H33 H35 L36 K40 L76 K83
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8a98, PDBe:8a98, PDBj:8a98
PDBsum8a98
PubMed38722744
UniProtQ4QCE1

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