Structure of PDB 7qh7 Chain i Binding Site BS01

Receptor Information

>7qh7 Chain i (length=97) Species: 9606 (Homo sapiens)

IGIRLTLPPPKVVDRWNEKRAMFGVYDNIGILGNFEKHPKELIRGPIWLR
GWKGNELQRCIRKRKMVGSRMFADDLHNLNKRIRYLYKHFNRHGKFR

Ligand information

>7qh7 Chain A (length=1256)

gcuaaaccuagccccaaacccccaccuuacuaccacaacuuagccaaacc
auuuacauaaaguauaggcgauagaaauugauggcgcaauagauauagua
ccgcaagggaaagacaagcauaauauagcaaggacuaaccccuauaccuu
cugcauaaugaauuaacuagaaauaacuuugcaaggagagccaaagcuaa
gacccccgaaaccagacgagcuaccuaagaacagcuaaaagagcacaccc
gucuauguagcaaaauagugggaagauuuauagguagaggcgacaaaccu
accgagccuggugauagcugguuguccaagauagaaucuuaguucaacuu
uaaauuugcccacagaaccaaauccccuuguaaauuuaacuguuagucca
aagaggaacagcucuuuggacacuaggaaaaaaccuuguagagagaguaa
aaaaugaucccaaacauauaacugaacuccucacacccaauuggaccaau
cuaucauauagaagaacuaauguuaguauaaguaacaugaaaacauucuc
cuccgcauaagccugcgucagaucugacaauuaacagcccaauaucuaca
aucaaccaacaaguuauuacccucacugucaacccaaccaggcaugcuca
uaaggaaagguuaaaaaaaguaaaaggaacucggcaaaucuuaccccgcc
uguuuaccaaaaacaucaccucuagcaucaccaguauuagaggcaccgcc
uccuuaaauaggcuccacgaggguucagcugucucuuacuuuuaaccagu
gaaauugaccugcccgugaggcgggcauaacacagcaagacgaagacccu
auggagcuuuaauuuauuaaugcaaaaccugcauuaaaaauuucgguugg
ggcgaccucggagcagaacccaaccuccgaggcuaagacuucaccaguca
aagcgaagauccaauaacuugaccaacggaacaaguuacccuagggcaau
ccuauucuagaguccauaucaacaauaggguuuacuggaucaggacaucc
cgauggugcagccgcuauuaaagguucguuuguucaacgauuaaaguccu
cgugaucugaguucagaccggaguaauccaggucgguuucuaucuacuuu
auuccucccuguacgaaaggacaagagaaauaaggccuacuucacaaagc
gccuucuaaaugauaucaucucaacuuaauacccacacccacccaagaac
aggguu

<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>....>>.>>.............
<<....>>........>>>...........<<<.......>>>...<.<<
......>>.>.<<<<<<.........<<<.<<..<<....>>...>>.>>
>...<<.<..<<<<<.<.....<<<<<.<<<..<<<.....>>>...<<<
..<<<<........>>>>.>>>....>>>.>>>>>...<<.......>>.
.....>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<
<<<<<<<<<.....<<......>>.....>>>>>>>>>>..>>>.<<<<<
<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<<...
<.....................>...>>>>>>........>>>>>>...<
<<<<...>>>>>.........>>>>>><......<<..<<<....>>><<
<<..<<<<........<<<<<..>>>>>......<<<...<<<<......
..............>>>>.......>>>.....<<.....>>.>>>>...
..>>>>..<<<<...<<<<<<<<.<<.........<......<<<<<<..
<<<.........>>>...<<<<<<.............>>>>>>.......
.<<<.....>>>.....>>.>>>>.....>..>>.>>>>>>>>>>>>.>>
.....>.....<<<<<.....>>>>>.......<<..<<<.<<...<<<<
<.<<<<<<..<<<<..<<<<<<<<.....>>>>>>>.>>>>>..<<<<..
...>>>><<<<<<...........>>>>>>.<<<..<<<<.....>>>>.
.>>>.......<<<....>>>............>>>>..>>>>>>>...<
<<<<<<...<<.......>>...>>>>>>>.....<<<<..<<<<<..<<
.<<<<<<......>>>>>>...>>.<<<<<.....>>>>>.....>>>>>
.....>>>>......<<<<<<<....>>>.>>>>....>>..>>>.>>..
<<<.<<<.................>>>.>>><<<<<...<<<....>>>.
>>>>>.<<<................>>>............<<<<......
.>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qh7 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
• Resolution: 2.89 Å
• Binding residue (original residue number in PDB): I32 R35 K42 R46 R51 G61 F66 K68 H69 P70 I78 W79 R93 K94 H108 K112 R113 R115 Y116 Y118 K119 H120 F121 K126 F127
• Binding residue (residue number reindexed from 1): I1 R4 K11 R15 R20 G30 F35 K37 H38 P39 I47 W48 R62 K63 H77 K81 R82 R84 Y85 Y87 K88 H89 F90 K95 F96

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

External links

• PDB: RCSB:7qh7, PDBe:7qh7, PDBj:7qh7
• PDBsum: 7qh7
• PubMed: 35177605
• UniProt: Q4U2R6|RM51_HUMAN Large ribosomal subunit protein mL51 (Gene Name=MRPL51)