Structure of PDB 7qh6 Chain i Binding Site BS01

Receptor Information

>7qh6 Chain i (length=97) Species: 9606 (Homo sapiens)

IGIRLTLPPPKVVDRWNEKRAMFGVYDNIGILGNFEKHPKELIRGPIWLR
GWKGNELQRCIRKRKMVGSRMFADDLHNLNKRIRYLYKHFNRHGKFR

Ligand information

>7qh6 Chain A (length=1133)

gcuaaaccuagccccaaacccccaccuuacuaccaaaccuuagccaaacc
auuuacauaaaguauaggcgauagaaauugggcgcaauagauauaguacc
gcaagggaaagaugaaaaaaccaagcauaauauagcaaggacuaaccccu
auaccuucugcauaaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagcuaaagauu
uauagguagaggcgacaaaccuaccgagccuggugauagcugguugucca
agauagaaucuuaguucaacuuuaaauuugcccacagaaccaaauccccu
uguaaauuuaacuguuaguccaaagaggaacagcucuuuggacacuagga
aaaaaccuuguagagagaguaaaaaauuaucccaaacauauaacugaacu
ccucacacccaauuggaccaaucuaucacccuauagaagaacuaauguua
guauaaguaacaugaaaacauucuccuccgcauaagccugcgucagacug
acaauuaacagcccaauaucuacaaucaaccaacaagucauuauuacccu
cacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaagua
aaaggaaaaucuuaccuguuuaccaaaaacaucaccucuagcaucaccag
uauuagaggcaccgcccagcugucucuuacuuuuaaccagugaaauugac
cugcccgugaagaggcgggcauaacacagcaagacgagaagacccuaugg
agcuuuaauuuauuaaugcaaacaccugcauuaaaaauuucgguuggggc
gaccucggagcagaacccaaccuccgagcaguacaugcuaagacuucacc
agucaaagcgaaccucaauugauccaauaacuugaccaacggaacaaguu
acccuagggauaacagcgcaauccuaauaggguuuacgguucagaccgga
guaauccaggucgguuaucuacuuuauuccucccuguacgaaaggacaag
agaaauaaggccuacuucacaaagcgccuucccccguaaaugauaucauc
ucaacuuagauacccacacccaagaacaggguu

<<<.......<<<<...............................<....
..>.....<.....<<.....>>....>..>>.>>.............<<
....>>.................>>>...........<<<.......>>>
...<.<........>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<...<<<<.<.....<<<<<.<<<..........>>
>.>>>>>...<<.......>>......>.>>>>......>.>>..<<<<<
<....<<<<....>>>>.<<.<<<<<<<<<<.....<<......>>....
.>>>>>>>>>>..>>..<<<<<<<<<<......>>>>>>>>>>.<.<<<.
.....>>>.>..<<<.<<<...<.....................>...>>
>>>>........>>>>>>...<<<<<......>>>>>.........>>>>
>><......<<..<<<....>>><<<<..<<<<........<<<<<.>>>
>>......<<<...<<<<.......................>>>>.....
..>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<<
<.<<.............<<.........>>....<<<<<<..........
...>>>>>>..............>>.>>>>>>>>>>>>.>>.....>...
..<<<<<........>>>>>.......<<..<<<.........<<<<.<<
<<<<..<<<<..<<<<<<<<......>>>>>>>>.>>>>..<<<<.....
>>>><<<<<<...........>>>>>>..<<.....<<<..<<<<.....
>>>>..>>>....>>.........<<<....>>>............>>>>
..>>>>>>........<<..<<<<<...>>>>..>.>>.....<<<<<<<
....>>>.>>>>.....>>>.>>..<<<.<<<.................>
>>.>>><<<<<...<<<....>>>.>>>>>.......<<...........
.....>>..........<<<<.......>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7qh6 A late-stage assembly checkpoint of the human mitochondrial ribosome large subunit.
• Resolution: 3.08 Å
• Binding residue (original residue number in PDB): I32 L36 R46 R51 G61 F66 K68 W79 E87 R93 K94 H108 K112 R113 R115 Y116 Y118 H120 F121 H124 G125 K126 F127
• Binding residue (residue number reindexed from 1): I1 L5 R15 R20 G30 F35 K37 W48 E56 R62 K63 H77 K81 R82 R84 Y85 Y87 H89 F90 H93 G94 K95 F96

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7qh6, PDBe:7qh6, PDBj:7qh6
• PDBsum: 7qh6
• PubMed: 35177605
• UniProt: Q4U2R6|RM51_HUMAN Large ribosomal subunit protein mL51 (Gene Name=MRPL51)