Structure of PDB 7po4 Chain i Binding Site BS01

Receptor Information

>7po4 Chain i (length=93) Species: 9606 (Homo sapiens)

IGIRLTLPPPKVVDRWNEKRAMFGVYDNIGILGNFEKHPKELIRGPIWLR
GWKGNELQRCIRKRKMVGSRMFADDLHNLNKRIRYLYKHFNRH

Ligand information

>7po4 Chain A (length=1145)

gcuaaaccuagccccaaacccacuccaccuuacuaccagacaaccuuagc
caaaccauuuacccaaauaaaguauaggcgauagaaauugaaaccuggcg
caauagauauaguaccgcaagggaaagaugaaaaauuauaaccaagcaua
auauagcaaggacuaaccccuauaccuucugcauaaugaauuaacuagaa
auaacuuugcaaggagagccaaagcuaagacccccgaaaccagacgagcu
accuaagaacagcuaaaagagcaagauuuauagguagaggcgacaaaccu
accgagccuggugauagcugguuguccaagauagaaucuuaguucaacuu
uaaauuugcccacagaacccucuaaauccccuuguaaauuuaacuguuag
uccaaagaggaacagcucuuuggacacuaggaaaaaaccuuguagagaga
guaaaaaauuuaacacccauaguaggccuaaaagcagccaccaauuaaga
aagcguucaagcucaacacaucccaaacauauaacugaacuccucacacc
caauuggaccaaucuaucacccuauagaagaacuaauguuaguauaagua
acaugaaaacauucuccuccgcauaagccugcgucagauuaaaaugaacu
gacaauuaacagcccaauaucuacaaucaaccaacaagucauuauuaccc
ucacugucaacccaacacaggcaugcucauaaggaaagguuaaaaaaagu
aaaaggaacucggcaccuguuuaccaaaaacaucaccucuagcaucacca
guauuagaggcaguucagcugucucuuacuuuuaaccagugaaauugacc
ugcccgugaagaggcgggcauaacacagcaagacgagacccuauggagcu
uuaauuuauuaaugcaaacaguaccaaaccugcauuaaaagcaguacaug
cuaagacuucaccagucaaagcgaacuauccaauaacuugaccaacggaa
caaguuacccuaggcuaucuacuuucaaauuccucccuguacgaaaggac
aagagaaauaaggccuacuucacaaagcgccuuccccuaaaugauaucau
cucaacuuaguauuauacccacacccacccaagaacaggguuugu

<<<.......<<<<....................................
.<......>...............<<.....>>.............>>.>
>.............<<....>>......................>>>...
........<<<.......>>>...<.<........>.>.<<<<<<.....
....<<<.<<..<<....>>...>>.>>>...<<.<..<<<<<.<.....
<<<<<.<<<..<<.......>>....>>>.>>>>>...<<.......>>.
.....>.>>>>...>..>.>>..<<<<<<....<<<<....>>>><<<.<
<<<<<<<<<.....<<..........>>.....>>>>>>>>>>..>>>.<
<<<<<<<<<......>>>>>>>>>>...<<<......>>>....<<<.<<
<...<...................<<<.........>>>...........
.<<<......>>>......................>...>>>>>>.....
...>>>>>>...<<<<<......>>>>>.........>>>>>><......
<<..<<<....>>><<<<..<<<<........<<<<<.<<.....>>.>>
>>>......<<<...<<<<.......................>>>>....
...>>>.....<<......>>.>>>>.....>>>>..<<<<...<<<<<<
<<.<<.......<<...<<<<<.....>>>>>...<<<<<<.........
....>>>>>>.......>>...>>.>>>>>>>>>>>>.>>.....>....
.<<<<<........>>>>>.......<<..<<<.......<<<.<.<<<<
........<<<<<<<<....<..>......>>>>>>>>...........<
<<..<<<<.....>>>>..>>>........<<<....>>>..........
..>>>>...>>>>....>>>.>>...<.<<<.<<<...............
..>>>.>>><<<<<...<<<....>>>.>>>>>.....<<.<........
....>.>>.......>..........<<<<.......>>>>....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7po4 Mechanism of mitoribosomal small subunit biogenesis and preinitiation.
• Resolution: 2.56 Å
• Binding residue (original residue number in PDB): I32 G33 I34 R35 L36 R46 K50 R51 F66 K68 H69 P70 E72 R75 G76 P77 W79 R81 R93 K94 R95 K96 H108 N111 K112 R113 R115 Y116 Y118 K119 H120 R123
• Binding residue (residue number reindexed from 1): I1 G2 I3 R4 L5 R15 K19 R20 F35 K37 H38 P39 E41 R44 G45 P46 W48 R50 R62 K63 R64 K65 H77 N80 K81 R82 R84 Y85 Y87 K88 H89 R92

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7po4, PDBe:7po4, PDBj:7po4
• PDBsum: 7po4
• PubMed: 35676484
• UniProt: Q4U2R6|RM51_HUMAN Large ribosomal subunit protein mL51 (Gene Name=MRPL51)