Structure of PDB 7oi6 Chain i Binding Site BS01

Receptor Information

>7oi6 Chain i (length=97) Species: 9606 (Homo sapiens)

IGIRLTLPPPKVVDRWNEKRAMFGVYDNIGILGNFEKHPKELIRGPIWLR
GWKGNELQRCIRKRKMVGSRMFADDLHNLNKRIRYLYKHFNRHGKFR

Ligand information

>7oi6 Chain A (length=1208)

gcuaaaccuagccccaaacccacuccaccuuacuaccaaaccuuagccaa
accauuuacauaaaguauaggcgauagaaauugggcgcaauagauauagu
accgcaagggaaagaugaaaaauaccaagcauaauauagcaaggacuaac
cccuauaccuucugaugaauuaacuagaaauaacuuugcaaggagagcca
aagcuaagacccccgaaaccagacgagcuaccuaagaacagauuuauagg
uagaggcgacaaaccuaccgagccuggugauagcugguuguccaagauag
aaucuuaguucaacuuuaaauuugcccacagaaccaaauccccuuguaaa
uuuaacuguuaguccaaagaggaacagcucuuuggacacuaggaaaaaac
cuuguagagagaguaaaaaauuuaacacccauaguaggccuaaaagcagc
caccaauuaagaaagcguucaagcucaacaccucccaaacauauaacuga
acuccucacacccaauuggaccaaucuaucacccuauagaagaacuaaug
uuaguauaaguaacaugaaaacauucuccuccgcauaagccugcgucaga
ucacugacaauuaacagcccaauaucuacaaucaaccaacaagucauuau
uacccucacugucaacccaacaggcaugcucauaaggaaagguuaaaaaa
aguaaaaggaaacaucaccucuagcaucaccaguauuagaggccagcugu
cucuuacuuuuaaccagugaaauugaccugcccgugaggcgggcauaaca
cagcaagacgagacccuauggagcuuuaauuuauuaaugcaaacaccugc
auuaaaaauuucgguucggagcagaacccaaccuccgagcaguacaugcu
aagacuucaccagucaaagcgaaccucaauugauccaauaacuugacgga
acaaguuacccuaggggcgcaauccuauucuagaguccauaucaacaaua
ggguuuacgaccucuguuggaucaggacaucccgauggugcagccgcuau
uaaagguucguuuguucaacgauuaaaguccuacgugaucugaguuuauc
uacuuuauuccucccuguacgaaaggacaagagaaauaaggccuacuuca
caaagcgccuucuaaaugauaucaucucaacuuaauacccacacccaaga
acaggguu

<<<.......<<<<..................................<.
.....>.....<.....<<.....>>....>..>>.>>............
.<<....>>..................>>>...........<<<......
.>>>...<.<....>.>.<<<<<<.........<<<.<<..<<....>>.
..>>.>>>...<<.<..<<<<<.<.....<<<<<.<<<....>>>.>>>>
>...<<.......>>......>.>>>>>.....>.>>..<<<<<<....<
<<<....>>>><<<.<<<<<<<<<<.....<<......>>.....>>>>>
>>>>>..>>>.<<<<<<<<<<......>>>>>>>>>>...<<<......>
>>....<<<.<<<...<..............<....<<<.........>>
>....>.......<<<......>>>......................>..
.>>>>>>........>>>>>>...<<<<<......>>>>>.........>
>>>>><......<<..<<<....>>><<<<..<<<<........<<<<<.
...>>>>>......<<<...<<<<.......................>>>
>.......>>>.....<<....>>.>>>>.....>>>>..<<<<...<<<
<<<<<.<<.........<<<<<<.............>>>>>>........
>>.>>>>>>>>>>>>.>>.....>.....<<<<<.....>>>>>......
.<<..<<<.....<<<<<.<<<<<<..<<<<<.<<<<<<<<......>>>
>>>>>>>>>>.....<<<<<<...........>>>>>>..<<.....<<<
..<<<<.....>>>>..>>>....>>.........<<<....>>>.....
...>>>>..>>>>>>>.<<....<<<.<<...<<.......>>...>>.>
>>.....>>..............<<<<<..<<.<<<<<<......>>>>>
>...>>.<<<<<.....>>>>>.....>>>>>................>>
>.>>..<<<.<<<.................>>>.>>><<<<<...<<<..
..>>>.>>>>>.<<<.<............>.>>>........<<<<....
...>>>>.

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7oi6 A distinct assembly pathway of the human 39S late pre-mitoribosome.
• Resolution: 5.7 Å
• Binding residue (original residue number in PDB): I32 I34 R35 L36 G61 H69 P77 Y116 F121 G125 K126 F127
• Binding residue (residue number reindexed from 1): I1 I3 R4 L5 G30 H38 P46 Y85 F90 G94 K95 F96

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0005515 protein binding

Biological Process

• GO:0006412 translation
• GO:0032543 mitochondrial translation

Cellular Component

• GO:0005739 mitochondrion
• GO:0005743 mitochondrial inner membrane
• GO:0005761 mitochondrial ribosome
• GO:0005762 mitochondrial large ribosomal subunit
• GO:0005840 ribosome
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:7oi6, PDBe:7oi6, PDBj:7oi6
• PDBsum: 7oi6
• PubMed: 34315873
• UniProt: Q4U2R6|RM51_HUMAN Large ribosomal subunit protein mL51 (Gene Name=MRPL51)