Structure of PDB 7ns4 Chain i Binding Site BS01

Receptor Information
>7ns4 Chain i (length=358) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSIFNEPDVDFHLKLNQQLFHIPYELLSKRIKHTQAVINKETKSLHEHTA
ALNQIFEDELALAKITEMIRKVDHIERFLNTQIKSYCQILNRIKKRLEFF
HELKDIKSQGTRTKLIQWYQSYTNILIGDYLTRNNPIKYHWNSGVVFLKQ
SQLDDLIDYDVLLEANRISTSLLHERNLLPLISWINENKKTLTKKSSILE
FQARLQEYIELNLLDDQRWSVLNDLFLSDFYSMYGISQNDPLLIYLSLGI
SSLKTRDCLHPDLQLFTLHSLKRKNCPVCSETFKPITQALPFAHHIQSQL
FENPILLPNGNVYDSKKLKKLAKTLKKQNLISLNPGQIMDPVDMKIFCES
DSIKMYPT
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain7ns4 Chain i Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB7ns4 GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme.
Resolution3.9 Å
Binding residue
(original residue number in PDB)		C395 C434
Binding residue
(residue number reindexed from 1)		C258 C276
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0016567 protein ubiquitination
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045721 negative regulation of gluconeogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0034657 GID complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ns4, PDBe:7ns4, PDBj:7ns4
PDBsum7ns4
PubMed33905682
UniProtP40492|FYV10_YEAST Protein FYV10 (Gene Name=FYV10)

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