Structure of PDB 6yan Chain i Binding Site BS01

Receptor Information

>6yan Chain i (length=59) Species: 9986 (Oryctolagus cuniculus)

KVHGSLARVGKVRGQTLKVAKQEKKKKRTGRAKRRMQYNRRFVNVVPTFG
KKKGPNANS

Ligand information

>6yan Chain 2 (length=1744)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgccuacuuggauaacugugguaauu
cuagagcuaauacaugccgacggcgcugacucccuuugugugggaugcgu
gcauuuaucagaucaaaaccaacccggucggcggcuuuggugacucuaga
uaaccucgggccgaucgcagcccuccguggcggcgacgacccauucgaac
gucugcccuaucaacuuucgaugguagucgccgugccuaccauggugacc
acgggugacggggaaucaggguucgauuccggagagggagccugagaaac
ggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacucccga
cccggggagguagugacgaaaaauaacaauacaggacucuuucgaggccc
uguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauuggag
ggcaagucuggucgcagcagccgcgguaauuccagcuccaauagcguaua
uuaaaguugcugcaguuaaaaagcucguaguuggaucuuguggaggguuc
cccgccccuugccucucggcgccggcccgaagcguuuacuuugaaaaaau
uagaguguucaaagcaggcccgagccgccuggauaccgcagcuaggaaua
auggaauaggaccgcgguucuauuuuguugguuuucggaacugaggccau
gauuaagagggacggccgggggcauucguauugcgccgcuagaggugaaa
uucuuggaccggcgcaagacggaccagagcgaaagcauuugccaagaaug
uuuucauuaaucaagaacgaaagucggagguucgaagacgaucagauacc
gucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcguuau
ucccaugacccgccgggcagcuuccgggaaaccaaagucuuuggguuccg
gggggaguaugguugcaaagcugaaacuuaaaggaauugacggaagggca
ccaccaggaguggagccugcggcuuaauuugacucaacacgggaaaccuc
acccggcccggacacggacaggauugacagauugauagcucuuucucgau
ucugugggugguggugcauggccguucuuaguugguggagcgauuugucu
gguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuacgcga
cccccgagcggucggcgucccccaacuucuuagagggacaaguggcguuc
agccacccgagauugagcaauaacaggucugugaugcccuuagaugucgg
ggcugcacgcgcgcuacacugacuggcucagcgugugccuacccuacgcc
ggcaggcgcggguaacccguugaaccccauucgugauggggaucggggau
ugcaauuauuccccaugaacgaggaauucccaguaagugcgggucauaag
cuugcguugauuaagucccugcccuuuguacacaccgcccgucgcuacua
ccgauuggaugguuuagugaggcccucggaucggcccgccggggugcccu
ggcggagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaa
gucguaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[.((((((.....{{.........[[[.
[[[..<<....<<....<<..........>>...>>.>>......{{...
.....[[[......{{....[[[.........<<.....<<.<<<.....
>>>.>>......>>........<<<<...<<.<......>.>>...>>>>
[[..(((((.....<<<<<<<<<<<<.....>>>....<......>..))
)))......]]...<<<<.<<<......>>>.>>>>....]]]...}}..
..]]].<<<....<<<....<<<<<<<.........>>>>>>>>>>....
..>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<.........
.>>>.>>.<.<<....>>.>...]]]]]].........<<<....<<<<.
..>>>>..>>>......}}.......<<<<<<<<<.<<<....>>>.>>.
>>>>.>>>......<<..<...........>..>>.........<<<<<(
(....<.<<<<.....<<..))>>.......>>>>>>>>>>..)))))).
]]]............{{.......{{...[[[.[[....<<<<.<<...>
>>>>>........<......<<..>>....>....<<<<<<.<.......
<<...<.......>.<<<<.......>>>>...>>......>.>>>..>>
>.......[[....(((((((.....>>>>>>>>>.)))))))...]]..
..]]....<<<<<<..<...<<<<..<<..<<<<<<<<...<<<......
>>>......>>>>>>>>..>>.......<<....>>...>>>>..>..>>
>.>>>...]]]...}}......<<<<<<<...<...<<<<.<.....>.>
>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<<<<<
....>>>>>>>>>>>.>..>>>...<<..}}>>...>>.....>>>....
.<<<......<<<......>>>....>>>..]]]]..<<<<<.<<<<<<<
..<<..<<<<<..<<<.<<<<<<......<<........>>.........
.<<<<<......<<<<<<.......<<.<<<........>>>.>>.....
>>>>>>...<<.<<<..<<<<<<<<<....<<<.<<<<<....>>>...<
<<......>>>...>>.>>>....<<<...<...<<<<..<<<<....<<
<.<.<<<....>>>>.>>>....>>>>..>>>>..>.....<<<<<....
.>>>>>........>>>....>>>.>>>...>.>>>>>>>......>>>>
>...>>.>>>>.>>>.....<<.<<<........<.......<<<.<<<<
....>>>>.>>>....>.........>>>.>>............<<<<<.
.........>>>>>...........>>>>>.....<<<<<<<<.......
>>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.
<<....<<<<<<<<.<<<..<<<<.<<...<<<<<.<<<<<<<<..>>>>
>>>>....>>>>>...>>.>>>>..>>>.>>>>>>>>...>>.>>>>...
>.>>...>.....<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6yan Structural Insights into the Mammalian Late-Stage Initiation Complexes.
• Resolution: 3.48 Å
• Binding residue (original residue number in PDB): K75 V76 L80 V83 K85 V86 L91 K95 Q96 E97 K98 K100 R102 T103 R105 R108 R109 Q111 N113 N118 P129 N130 A131 N132
• Binding residue (residue number reindexed from 1): K1 V2 L6 V9 K11 V12 L17 K21 Q22 E23 K24 K26 R28 T29 R31 R34 R35 Q37 N39 N44 P55 N56 A57 N58

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:6yan, PDBe:6yan, PDBj:6yan
• PDBsum: 6yan
• PubMed: 32268096
• UniProt: G1T8A2|RS30_RABIT Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (Gene Name=FAU)