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Receptor Information

>6pto Chain i (length=594) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PDAVFGDRVRRFQEFLDTFTSYRDSVRSIQVYNSNNAANYNILPHRIIIS
LDDLREFDRSFWSGILVEPAYFIPPAEKALTDLADSMDDVPHHPWKLSFK
GSFGAHALSPRTLTAQHLNKLVSVEGIVTKTSLVRPKLIRSVHYAAKTGR
FHYRDYTDATTTLTTRIPTPAIYPTEDTEGNKLTTEYGYSTFIDHQRITV
QEMPEMAPAGQLPRSIDVILDDDLVDKTKPGDRVNVVGVFKSLGAGGMNQ
SNSNTLIGFKTLILGNTVYPLHAARQMLTDFDIRNINKLSKKKDIFDILS
QSLAPSIYGHDHIKKAILLMLMGGVEKNLENGSHLRGDINILMVGDPSTA
KSQLLRFVLNTASLAIATTGRGSSGVGLTAAVTTDRETGERRLEAGAMVL
ADRGVVCIDEFDKMTDVDRVAIHEVMEQQTVTIAKAGIHTTLNARCSVIA
AANPVFGQYDVNRDPHQNIALPDSLLSRFDLLFVVTDDINEIRDRSISEH
VLRTHRVTIPFLRKYVQYAKERVIPQLTQEAINVIVKNYTDLRNDDNTKK
SPITARTLETLIRLATAHAKVRLSKTVNKVDAKVAANLLRFALL

Ligand ID

ATP

InChI

InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

InChIKey

ZKHQWZAMYRWXGA-KQYNXXCUSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341	Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04	O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0	c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341	Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O

Formula

C10 H16 N5 O13 P3

Name

ADENOSINE-5'-TRIPHOSPHATE

PDB chain

6pto Chain i Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6pto Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Resolution	7.0 Å
Binding residue (original residue number in PDB)	I371 P411 S412 T413 A414 K415 S416 Q417
Binding residue (residue number reindexed from 1)	I307 P347 S348 T349 A350 K351 S352 Q353
Annotation score	5

Enzyme Commision number

3.6.4.12: DNA helicase.

	Molecular Function
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003688	DNA replication origin binding
GO:0003697	single-stranded DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0016887	ATP hydrolysis activity
GO:0017116	single-stranded DNA helicase activity
GO:1904931	MCM complex binding

	Biological Process
GO:0000727	double-strand break repair via break-induced replication
GO:0006260	DNA replication
GO:0006267	pre-replicative complex assembly involved in nuclear cell cycle DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006279	premeiotic DNA replication
GO:0030466	silent mating-type cassette heterochromatin formation
GO:0031509	subtelomeric heterochromatin formation
GO:0032508	DNA duplex unwinding
GO:1902975	mitotic DNA replication initiation

	Cellular Component
GO:0000781	chromosome, telomeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005656	nuclear pre-replicative complex
GO:0005737	cytoplasm
GO:0031261	DNA replication preinitiation complex
GO:0031298	replication fork protection complex
GO:0042555	MCM complex
GO:0043596	nuclear replication fork
GO:0071162	CMG complex

PDB	RCSB:6pto, PDBe:6pto, PDBj:6pto
PDBsum	6pto
PubMed	31589141
UniProt	P24279\|MCM3_YEAST DNA replication licensing factor MCM3 (Gene Name=MCM3)

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Structure of PDB 6pto Chain i Binding Site BS01