Structure of PDB 6gsm Chain i Binding Site BS01

Receptor Information

>6gsm Chain i (length=95) Species: 559292 (Saccharomyces cerevisiae S288C)

GPKRELIYKEEGQEYAQITKMLGNGRVEASCFDGNKRMAHIRGKLRKKVW
MGQGDIILVSLRDFQDDQCDVVHKYNLDEARTLKNQGELPENAKI

Ligand information

>6gsm Chain 2 (length=1798)

uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacauggauaucug
ugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaagag
auguauuuauuagauaaaaaaucaaugucuucggacuccuugaugauuca
uaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaaa
uuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuuc
aacggguaacggggaauaaggguucgauuccggagagggagccugagaaa
cggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccua
auucagggagguagugacaauaaauaacgauacagggcccauucgggucu
uguaauuggaaugaguacaauguaaauaccuuaacgaggaacaacuggag
ggcaagucuggugccagcagccgcgguaauuccagcuccaguagcguaua
uuaaaguuguugcaguuaaaaagcucguaguugaacuuugggucugguug
uccgguccgacuuuaugucgcgcacugguuuucaaccggaucuuuccuuc
uggcuaaccuguacuccuugugggugcaggcgaaccaggacuuuuacuuu
gaaaaaauuagaguguucaaagcaggcgaaagcucgaauauauuagcaug
gaauaauggaauaggacguuugguucuauuuuguugguuucuaggaccau
cguaaugauuaauagggacggucgggggcaucaguauucaauugucagag
gugaaauucuuggauuuauugaagacuaacuacugcgaaagcauuugcca
aggacguuuucauuaaucaagaacgaaaguuaggggaucgaagaugauca
gauaccgucguagucuuaaccauaaacuaugccgacuagggaucgggugg
uguuuuucuuaugacccacucggcaccuuacgagaaaucaaagucuuugg
guucuggggggaguauggucgcaaggcugaaacuuaaaggaauugacgga
agggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggg
aaacucaccagguccagacacaauaaggauugacagauugagagcucuuu
cuugauuuugugggugguggugcauggccguucuuaguugguggagugau
uugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauaggg
uugcuggcacuugccgguugacucuucuuagagggacuaucgguuucaag
ccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguucu
gggccgcacgcgcgcuacacugacggagccagcgaguacaaccuuggccg
agaggucuggguaaucuugugaaacuccgucgugcuggggauagagcauu
guaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucagc
uugcguugauuacgucccugcccuuuguacacaccgcccgucgcuaguac
cgauugaauggcuuagugaggccucaggauuugcuuagagaagggggcaa
cuccaucucagagcgaagaaucuggucaaacuuggucauuuagaggaacu
aaaagucguaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...[[[[>>>>>[[[[.((((((................[[[
.[[[...<....<<....<<..........>>...>>.>.......{{..
......[[[......{{....[[[{...............<<.....<<.
.<.......>..>>......>>........<<<<<............>>>
>>{..[[.((((......<<<<<<<<.<......>...............
))))]].....}...<<<<..<<<.....>>>.>>>>..}.]]]...}}.
...]]].<<<....<<<....<<<<<<<<.......>>>>>>>>>>>...
...>>>...<<<.<<<<....>>>>....>>>.}}.<<.<<<........
..>>>.>>.<.<......>.>...]]]]]].........<<<....<<<.
....>>>..>>>................<..<<<<<.<.......>..>>
>>>...>.......<<..<...........>.>.>.........<<<<<(
(......<<<<.....<<..))>>.......>>>>.>>>>>..))))))]
]]].........[[[{{.......{{...[[[.{{.....<<<<<<<<<<
.<<<<<.<<<.......>>>...>>>>>....>>>>>>>>>>.....<<<
<<<......<.................>......>>>>>>...<<<<<.<
<......<<<...<.......>..<<<....>>>....>>.>....>>.>
>..>>>.........[[[..(((((((.....>>>>>>>>..))))))).
]]].....}}....<<<<<<.<<...<<<<..<<..<<<<<<.<...<<.
.......>>......>.>>>>>>..>>.......<<....>>...>>>>.
..>>>>>.>>>...]]]...}}......<<<<<<<...<...<<<<....
.....>>>>...>>>>>>>>..........<<<.<<.<<<..<<<<<<<<
.<<.<.......>>>>>>>>>>>..>>>...<<..}}>>...>>.....>
>>.]]].<<<......<.<......>.>....>>>..]]]]..<<<<<.<
<<<<<<..<<.<<<<<<..<<<.<<<<<<......<<........>>...
.......<<<<<.<....<<<<<........<<..<<........>>..>
>......>>>>>...<<.<<<..<<.<<<<<<....<<<.<<<<......
>>...<<<......>>>...>>.>>>....<<<<<.<<..<<<<....<<
<<<.<<<<....>>>>.>.>>>>....>>>>.>>....<<<<<<.....>
>>>>>.......>>>>>....>>>.>>>.....>>>>>>>.....>.>>>
>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<<..<<<.
...>>>..>>>....>>.......>>>>>>>......<....<<<<<<..
........>>>>>>....>.....>>>>>>....<<<<<<<<.......>
>>>>>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<.<
<....<<<<<<<<.<<<..<<<<......<<<<<<.<<............
......>>...>>>>>>......>>>>..>>>.>>>>>>>>...>>.>>>
>...>.>>...>.....<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6gsm Large-scale movement of eIF3 domains during translation initiation modulate start codon selection.
• Resolution: 5.15 Å
• Binding residue (original residue number in PDB): L42 G43 N44 R46 I61 R62 G63 K64 L65 R66 V69 M71
• Binding residue (residue number reindexed from 1): L22 G23 N24 R26 I41 R42 G43 K44 L45 R46 V49 M51

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003743 translation initiation factor activity

Biological Process

• GO:0006413 translational initiation

External links

• PDB: RCSB:6gsm, PDBe:6gsm, PDBj:6gsm
• PDBsum: 6gsm
• PubMed: 34648019
• UniProt: P38912|IF1A_YEAST Eukaryotic translation initiation factor 1A (Gene Name=TIF11)