Structure of PDB 6az3 Chain i Binding Site BS01

Receptor Information
>6az3 Chain i (length=97) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APTPRTGIIAGFNKGHVTTRRPRQPSPNDRFAVPHKHLRAVKAIIADLVG
LSPLEKRVQEFLRVGKEKRALKYCKKRLGDFTAAKKKRSKMEEALRH
Ligand information
>6az3 Chain 1 (length=1620) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucauuucgugguuggugcaggaguggcgaaauucaagcgcaaag
caaacccguugcugaauacaacccuucaugugaguauugagccaaagaag
guguuagcccauugagccauaaaccugagcgccucaugaacaagcgagua
gcacuguuugggaaugcagugucaaguggcagguauuugucugccaaagu
uaaauacagaguaggaagaccgauagcgaacaaguagcgugagcgaaagu
uugaaaagcacuuuggaaagagagugaaauagaaccugaagucgugacaa
agacaauggaaguaccuccauuucaacggccagaaccagcccuacugcau
uauccugucgggggucaaaauccggcgggcaagaagugcaagaagggucu
uggugaaaugagcggaguauuugagcugugcacggcgcgcacgcacucuu
cuccgugaugcuccauguuggcgaugaaauggggugcccccacccgucuu
gaaacacggaccaaggagucaaacagacgcgcaagggaggagauaugguu
gccaguacuuucucguacugaaagggagaugcaaaaugcaucuguggugu
gcacacgucauuugcccaacaccgaccggcccuccguggguugcguugga
gugugccuguuuggacccgaaagguggugaacuaugccugaacaagguga
agcccggggaaacccagguggaggccuguagcgaugcugacgugcaaauc
gcucguaugauuuggguaucggagcgaaagacucaucgaaccaccuagua
gcugguucacaucgaaguuucccucaggauagcuggugcuaguagaagua
uugugcgguaaagcaaaugauuagaggcauugggaccuauucucaaacuu
uaaaugugcaaacaaaccggccuuagccaacugcaaggccggaaagaaaa
gaauuagaggcaccaagugggccuucuucgguaagcggagcaggcgaugc
ggaaugaaccgcuuagggauauguggcgucaaaacuuaugggcucauucu
cgauacguaaaggguguugguggauauccaccggccccgaaaauggauga
cgcuuaagcccaauuagugauugcccauuauuccuuugguaagggcggaa
acaaaggagaaaguguagcccuuccgauguagauguggccuggagguuag
gacgaagcuuauggcgugagccuaagauggaccggccucuagugcagauc
uugguuggcguagcaaagaucuaacggagauauacucaacaugcaacguu
ggauacuggagcggggaaggauuucgugccaacggcacucguacacgagu
uguucggaaacugagcacaacguuauaucguuuuguuaggaaagugaagg
uggucggccauaacugaaaaggggcaacagagaaccugggauuauauucc
aaaaagaaauugcauguggg
......................<<<<<......<<....>>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
..........<<<<<<...<<<<<<<<.<<<<<......<<<......<<
<<.......>>>>.....<<........>>......>>>.<<.......(
(.....>>)).....>>>>>...>>>..>>>>>.>>>>>>..........
<<<<<<<........>>>>>>>.....<<<<<........>>>>>..>>>
....................................<<....>>......
..........<<<......>>>............................
......(((..<<<<<<.<<<<<<..((.<<<<.<<<<<<<<<...<<<<
...<<<<<<<<<........>>>>>>>>>.....>.>>>....>>>>>..
>>>>........<<<<<.....<<...<<<<.<<...>>...>>>>>>..
>>>>>.....<<<<...>>>>))..>>>>>>>>>>>>..))).<<<<...
.....>>>><<<<<<...<<<<<<<<.<<<<<..<<<.<<<<.<......
......>>>>>>>>...<<....>>..<<<<<.....>>>>>...<<<<<
...<<.<...>.>>....>>>>><<<<<<<<<.....>>>>>>.>>>...
>>>>>.>>>>>>>>.<<.<..<<<<<<<.....<<<<<<<<<..<<<...
.<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<........>>
>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>...>.
.>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...
<<<<<<<...<<<....<<<....<<<...<..>.>>>....>>>..>.>
>...>>>>>>>.....<<<<<<<<.<<.....>>>>>>>>>>........
...>>...>>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<
<<......>>>>..<<<<<<<...<<<(((......<..<<<<.......
.<.........<<<.<<<<<<<<<..>>>>>>>>>>>>..........))
).>....>>>>.>.........>>>...>>>>>>>((((.<<<<<.....
.....>>>>.........>>>>>))))....>>>>>....<<<<<<<<..
.......<<<..<<<....>>>.>>>.......>>>>>>>>........>
>>>>>..............<<<<<<<....................>>>>
>>>....................<<<<<....<<.....>>..>>>>>..
..<<..........<<.<<<<<......>>>>............<..<<.
<..........>.>>..>...>.>>..........<<<<.........>>
....>>.>>...........
Receptor-Ligand Complex Structure
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PDB6az3 Atomic resolution snapshot of Leishmania ribosome inhibition by the aminoglycoside paromomycin.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		G17 H18 R25 S28 P29 N30 R32 F33 P36 H37 K38 H39 L40 R41 K44 R79 L80 G81 F83 K87 K88
Binding residue
(residue number reindexed from 1)		G15 H16 R23 S26 P27 N28 R30 F31 P34 H35 K36 H37 L38 R39 K42 R77 L78 G79 F81 K85 K86
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6az3, PDBe:6az3, PDBj:6az3
PDBsum6az3
PubMed29150609
UniProtA0A3Q8IDW6

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