Structure of PDB 5nco Chain i Binding Site BS01

Receptor Information
>5nco Chain i (length=450) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFIN
RVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVV
LMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAE
QVGVDFFPSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMD
EIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGD
ARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILGMGDVLSL
IEDIESKVDRAQAEKLASKLKKGDGFDLNDFLEQLRQMKNMGGPPPPPPP
PPPPPPPPPPPPPPPDDKVLVRMEAIINSMTMKERAKPEIIKGSRKRRIA
AGCGMQVQDVNRLLKQFDDMQRMMKKMKKGGPPPPPPPPPPPPPPPPPPP
Ligand information
>5nco Chain 1 (length=104) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggcucuguugguucucccgcaacgcuacucuguuuaccaggucagguccg
gaaggaagcagccaaggcagaugacgcgugugccgggauguagcuggcag
ggcc
<<<<<<<<<<<<<.<<<<<<<...<..<<<<<<<<....<<<....<<<.
...>>>....>>>.>>>>>>>.>..>....>>>.>>>>...>>>>>>>>>
>>>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5nco Structure of the quaternary complex between SRP, SR, and translocon bound to the translating ribosome.
Resolution4.8 Å
Binding residue
(original residue number in PDB)		E277 K278 A378 N381 S382 M383 T384 K386 S397 R398 R401 G405 C406
Binding residue
(residue number reindexed from 1)		E274 K275 A375 N378 S379 M380 T381 K383 S394 R395 R398 G402 C403
Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0008312 7S RNA binding
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006612 protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0048500 signal recognition particle
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5nco, PDBe:5nco, PDBj:5nco
PDBsum5nco
PubMed28524878
UniProtP0AGD7|SRP54_ECOLI Signal recognition particle protein (Gene Name=ffh)

[Back to BioLiP]