Structure of PDB 7pzy Chain h Binding Site BS01

Receptor Information
>7pzy Chain h (length=311) Species: 237561 (Candida albicans SC5314) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QEVLVLRGTLEGHNGWVTSLATTPAHPDLLLSGSRDKTLIKWKLTGGEDN
QYGIPKKSFKGHSHIVQDVTISADGAYALSASWDRTLRLWDLETGETTQR
FVGHKGDVLSVSIAKNLRQIVSASRDKTVKVWNTIGECMATLTGHNDWVS
AVRISPSDQSSTVISASWDKTVKSWDLADYSVNADFIGHTGYISCITLSP
DGSLCASAGKDGVIILWDLNKNKTLYTLEAKAEVHALAFSPNRYWLAAAT
TSGIKIFKLQERSLLDELKPEFAVGATAKDPEAISLAWSADGQNLFAGYT
DNVIRVWQVMT
Ligand information
>7pzy Chain A (length=1692) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguauacuuggauaaccgugguaau
ucuagagcuaauacaugcuuaaaaucccgacuguuuggaagggauguauu
uauuagauaaaaauuugaugauucauaauaacuuuucgaaucgcauggcc
uugugcuggcgaugguucauucaaauuucugcccuaucaacuuucgaugg
uaggauaguggccuaccaugguuucaacggguaacggggaauaaggguuc
gauuccggagagggagccugagaaacggcuaccacauccaaggaaggcag
caggcgcgcaaauuacccaaucccgacacggggagguagugacaauaaau
aacgauacagguuguaauuggaaugaguacaauguaaauaccuuaacgag
gaacaauuggagggcaagucuggugccagcagccgcgguaauuccagcuc
caaaagcguauauuaaaguuguugcaguuaaaaagcucguaguugaaccu
ugggcuuggcuggccgguccuggacccagccgagccuuuccuucuggcca
ggacuuuuacuuugaaaaaauuagaguguucaaagcaggccuuugcucga
auauauuagcauggaauaauagaauaggacguuaugguucuauuuuguug
guuucuaggaccaucguaaugauuaauagggacggucggggguaucagua
uucaguugucagaggugaaauucuuggauuuacugaagacuaacuacugc
gaaagcauuuaccaaggacguuuucauuaaucaagaacgaaaguuagggg
aucgaagaugaucagauaccgucguagucuuaaccauaaacuaugccgac
uagggaucgguuguuguucuuuuauugacgcaaucggcaccuuacgagaa
aucaaagucuuuggguucuggggggaguauggucgcaaggcugaaacuua
aaggaauugacggaagggcaccaccaggaguggagccugcggcuuaauuu
gacucaacacggggaaacucaccagguccagacacaauaaggauugacag
auugagagcucuuucuugauuuugugggugguggugcauggccguucuua
guugguggagugauuugucugcuuaauugcgauaacgaacgagaccuuaa
ccuacuaaauagugcugcuagcauuugcugguauagucacuucuuagagg
gacuaucgauuucaagucgauggaaguuugaggcaauaacaggucuguga
ugcccuuagacguucugggccgcacgcgcgcuacacugacggagccagcg
aguauaagccuuggccgagaggucugggaaaucuugugaaacuccgucgu
gcuggggauagagcauuguaauuguugcucuucaacgaggaauuccuagu
aagcgcaagucaucagcuugcguugauuacgucccugcccuuuguacaca
ccgcccgucgcuacuaccgauugaauggcuuagugaggccuccggauugg
uuuagggaaccgagaagcuggucaaacuuggucauuuagaggaaguaaaa
gucguaacaagguuuccguaggugaaccugcggaaggaucau
...<<<<<.[.((((>>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<<..........>>...>>.>>......<<..
......<<<..<<..<<....<<<.........<<.....<..<<<....
.>>>..>......>>........<<<<<..<<....>>..>>>>><...<
<<<<<......[.............>>>>>>.....>...<<<<..<<<.
....>>>.>>>>....>>>...>>>>..>>>.<<<....<<<....<<<<
<<<<.......>>>>>>>>>>>......>>>...<<<.<<<<....>>>>
....>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>
>>>>>.........<<<....<<<<...>>>>..>>>..>....>.>...
..<<<<...<..>...>>>>......<<..<...........>..>>...
......<<<<<((....<.<<<<.....<<..))>>.......>>>>>>>
>>>..>>>>>>>>>>.........<<<((.....<.<<...<<<.<<...
.<<<<<<<<<<<<............>>>>>>>>>>>>....<<<<<..>>
>>>...<<<<<.<<.......<<...<.......>..<<<....>>>...
.>>......>>.>>..>>>.........<<<..<<<<<<<<<........
...].>>>>>>>>>>>>.....>>....<<<<<<.<<...<<<<..<<..
<<<<<<.<...<<<......>>>......>.>>>>>>..>>.......<<
....>>...>>>>...>>>>>.>>>...>>>...>>.>....<<<<<<<.
..<...<<<<.<.....>.>>>>...>>>>>>>>..........<<<.<<
.<<<..<<<<<<<<..<<........>>.>>>>>>>>..>>>...<<..)
)>>...>>.....>>>.>>>.<<<......<<<<....>>>>....>>>.
.)))).]<<<<<.<<<<<<<..<<.<<<<<<..<<<.<<<<<<......<
<........>>..........<<<<<.<....<<<<<........<<.<<
<........>>>.>>......>>>>>...<<.<<<..<<.<<<<<.....
<<<.<<<<<....>>>...<<<......>>>...>>.>>>....<<<<<.
<<..<<<<..<<<<.<<<<<<<....>>>>>>>....>>>>..>>>>.>>
....<<<<<<.....>>>>>>.......>>>>>.....>>.>>>.....>
>>>>>>.....>.>>>>>...>>.>>>>.>>>.....<<<<<<<......
<<......<<<.<<<<....>>>>.>>>....>>.......>>>>>>>..
....<....<<<<<<..........>>>>>>....>.....>>>>>>...
.<<<<<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>..
..<..<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<..<...<<<<
<.......>>>>>...>..>>>>..>>>.>>>>>>>>...>>.>>>>...
>.>>...>.....<<<<<<<<<<..>>>>>>>>>>.......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7pzy E-site drug specificity of the human pathogen Candida albicans ribosome.
Resolution2.32 Å
Binding residue
(original residue number in PDB)
G64 H67 A279 T280 A281
Binding residue
(residue number reindexed from 1)
G61 H64 A276 T277 A278
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001965 G-protein alpha-subunit binding
GO:0005080 protein kinase C binding
GO:0005092 GDP-dissociation inhibitor activity
GO:0030546 signaling receptor activator activity
GO:0043022 ribosome binding
GO:0045182 translation regulator activity
Biological Process
GO:0001403 invasive growth in response to glucose limitation
GO:0006412 translation
GO:0006521 regulation of cellular amino acid metabolic process
GO:0007155 cell adhesion
GO:0007186 G protein-coupled receptor signaling pathway
GO:0009267 cellular response to starvation
GO:0010508 positive regulation of autophagy
GO:0010629 negative regulation of gene expression
GO:0017148 negative regulation of translation
GO:0030447 filamentous growth
GO:0031139 positive regulation of conjugation with cellular fusion
GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation
GO:0036178 filamentous growth of a population of unicellular organisms in response to neutral pH
GO:0036180 filamentous growth of a population of unicellular organisms in response to biotic stimulus
GO:0036244 cellular response to neutral pH
GO:0061157 mRNA destabilization
GO:0070651 nonfunctional rRNA decay
GO:0072344 rescue of stalled ribosome
GO:0140469 GCN2-mediated signaling
GO:1902660 negative regulation of glucose mediated signaling pathway
GO:1903138 negative regulation of cell integrity MAPK cascade
GO:1903753 negative regulation of p38MAPK cascade
GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process
GO:1990145 maintenance of translational fidelity
GO:2000765 regulation of cytoplasmic translation
GO:2001125 negative regulation of translational frameshifting
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:1903561 extracellular vesicle
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7pzy, PDBe:7pzy, PDBj:7pzy
PDBsum7pzy
PubMed35613268
UniProtP83774|GBLP_CANAL Small ribosomal subunit protein RACK1 (Gene Name=ASC1)

[Back to BioLiP]