Structure of PDB 6y7c Chain h Binding Site BS01

Receptor Information
>6y7c Chain h (length=179) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFESRKIMVPPHRMTPLRNSWTKIYPPLVEHLKLQVRMNLKTKSVELRTN
PKFTTDPGALQKGADFIKAFTLGFDLDDSIALLRLDDLYIETFEVKDVKT
LTGDHLSRAIGRIAGKDGKTKFAIENATRTRIVLADSKIHILGGFTHIRM
ARESVVSLILGSPPGKVYGNLRTVASRLK
Ligand information
>6y7c Chain 2 (length=1735) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaucugguugauccugccaguagucauaugcuugucucaaagauuaagcc
augcaugucuaaguauaagcaauuuauacagugaaacugcgaauggcuca
uuaaaucaguuaucguuuauuugauaguuccuuuacuacaugguauaacu
gugguaauucuagagcuaauacaugcuuaaaaucucgacccuuuggaaga
gauguauuuauuagauaaaaaaucaaugucuucggacucuuugaugauuc
auaauaacuuuucgaaucgcauggccuugugcuggcgaugguucauucaa
auuucugcccuaucaacuuucgaugguaggauaguggccuaccaugguuu
caacggguaacggggaauaaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccaauccu
aauucagggagguagugacaauaaauaacgauacagggcccauucggguc
uuguaauuggaaugaguacaauguaaauaccuuaacgaggaacaauugga
gggcaagucuggugccagcagccgcgguaauuccagcuccaauagcguau
auuaaaguuguugcaguuaaaaagcucguaguugaacuuugggcccgguu
ggccggucggauuuccaacggggccuuuccuucuggcuaaccaggacuuu
uacuuugaaaaaauuagaguguucaaagcaggcguauugcucgaauauau
uagcauggaauaauagaauaggacguuugguucuauuuuguugguuucua
ggaccaucguaaugauuaauagggacggucgggggcaucaguauucaauu
gucagaggugaaauucuuggauuuauugaagacuaacuacugcgaaagca
uuugccaaggacguuuucauuaaucaagaacgaaaguuaggggaucgaag
augaucagauaccgucguagucuuaaccauaaacuaugccgacuagggau
cgggugguguuuuuuuaaugacccacucggcaccuuacgagaaaucaaag
ucuuuggguucuggggggaguauggucgcaaggcugaaacuuaaaggaau
ugacggaagggcaccaccaggaguggagccugcggcuuaauuugacucaa
cacggggaaacucaccagguccagacacaauaaggauugacagauugaga
gcucuuucuugauuuugugggugguggugcauggccguucuuaguugguu
uugucugcuuaauugcgauaacgaacgagaccuuaaccuacuaaauagug
gugcuagcauuugcugguuauccacuucuuagagggacuaucgguuucaa
gccgauggaaguuugaggcaauaacaggucugugaugcccuuagacguuc
ugggccgcacgcgcgcuacacugacggagccagcgagucuaaccuuggcc
gagaggucuugguaaucuugugaaacuccgucgugcuggggauagagcau
uguaauuauugcucuucaacgaggaauuccuaguaagcgcaagucaucag
cuugcguugauuacgucccugcccuuuguacacaccgcccgucgcuagua
ccgauugaauggcuuagugaggccucaggaucugcuuagagaucucagag
cggagaauuuggacaaacuuggucauuuagaggaacuaaaagucguaaca
agguuuccguaggugaaccugcggaaggaucauua
...<<<<......[[.>>>><<<<.<<<<<<...<.<...<......<<<
.<<<..<<....<<....<............>...>>.>>......<<..
......<<<..<<..<<....<<<..................<.....<<
.<<<.....>>>.>>......>.........<<<<<..<<....>>..>>
>>><...<<<<<<......((((((................<<......>
>>>>>>>.....>...<<<<..<<<.....>>>.>>>>....>>>...>>
>>..>>>.<<<....<<<....<<<<<<<<.......>>>>>>>>>>>..
....>>>...<<<.<<.<....>.>>....>>>.>>.<<.<<<.......
...>>>.>>.<.<<....>>.>...>>>>>>.........<<<....<<<
.....>>>..>>>..>....>.>.....<<<.<<<<<<<<......>>>>
>>>>..>>>......<<.................>>.........<<<<<
((......<<<<.....<...)).>.......>>>>.>>>>>..>>>>>>
>>>>.........<<<[[.....<.<<...<<<.<<....<<<<<<.<<<
<<............>>>>>>.>>>>>.......<<<....>>>......<
<<<<.<<.......<<...<.......>..<<<.....>>>....>>...
...>>.>>..>>>..............<<<<.<<.......))))))..>
>.>>>>.........>>....<<<.<<.<<...<<<<..<<..<<<<<<.
....<<........>>........>>>>>>..>>......<<<....>>>
..>>>>..>>.>>..>>>...>>>...>>.>....<<<<<<..<.<...<
<<<.........>>>>...>>>>>>>>..........<<<..<.<<<..<
<<<<<<..<<..........>>.>>>>>>>..>>>...<<..]]>>...>
......>>>.>>>.<<<......<<<<....>>>>....>>>..]]....
...<<.<<<<<<<..<<..<<<....<<<.<<<<<<..............
..............<<<<<......<<.<<...........<<<......
..>>.>........>>.>>..........<<<..<<.<......<<.<<.
....................>>.>>.....<<<<........<<..<<<<
<.<<<<<<....>>>>>>...>>>>>..>>...........<<<<.....
>>>>..........>>>>.....>..>>...>>>..............>>
>>>...>>.>>>>.>>>.....<<<<<<<......<<.....<<......
..........>>....>>.......>>>>>>>...........<<<<<<.
.........>>>>>>............>>>......<<<<<<<.......
>>>>>>>.......>>...>>>>>>>>>.....<<<....<....<<<<.
<<..<<<<<<<<<<.<<<..<.<<..<...<<<<<<............>>
>>>>...>..>>.>..>>>.>>>>>>>>>>.>>.>>>>.....>......
.>>>.<<<<<<<<....>>>>>>>>..........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6y7c Good Vibrations: Structural Remodeling of Maturing Yeast Pre-40S Ribosomal Particles Followed by Cryo-Electron Microscopy.
Resolution3.8 Å
Binding residue
(original residue number in PDB)		T107 R110 H197 R200 I202 G203 R204 G207 K208 D209 R241 R244 E245 L252 G253 S254 P256 G257 K258 N262 R269 K271
Binding residue
(residue number reindexed from 1)		T15 R18 H105 R108 I110 G111 R112 G115 K116 D117 R149 R152 E153 L160 G161 S162 P164 G165 K166 N170 R177 K179
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0042134 rRNA primary transcript binding
GO:0051082 unfolded protein binding
Biological Process
GO:0000056 ribosomal small subunit export from nucleus
GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0042254 ribosome biogenesis
GO:0042255 ribosome assembly
GO:0043248 proteasome assembly
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0030686 90S preribosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6y7c, PDBe:6y7c, PDBj:6y7c
PDBsum6y7c
PubMed32138239
UniProtQ99216|PNO1_YEAST Pre-rRNA-processing protein PNO1 (Gene Name=PNO1)

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