Structure of PDB 6wub Chain h Binding Site BS01

Receptor Information

>6wub Chain h (length=131) Species: 474186 (Enterococcus faecalis OG1RF)

VMTDPIADFLTRIRNANMVKHETLEVPASKIKRDIAEILKREGFIRDVEY
IEDDKQGVIRVFLKYGKNEERVITNLKRISKPGLRAYVKADEVPKVLNGL
GIAIISTSEGVITDKEARAKNIGGEVIAYVW

Ligand information

>6wub Chain a (length=1121)

ugagaguuugauccuggcucaggacgaacgcuggcggcgugccuaauaca
ugcaagucgaacgcuucuuggaaagaggaguggcggacgggugaguaaca
cguggguaaccuacccaucagagggggauaacacuuggaaacaggugcua
auaccgcauaacaguuuaugccgcauggcauaagagugaaaggcgcuuuc
gggugucgcugauggauggacccgcggugcauuagcuaguuggugaggua
acggcucaccaaggccacgaugcauagccgaccugagagggugaucggcc
acacugggacugagacacggcccagacuccuacgggaggcagcaguaggg
aaucuucggcaauggacgaaagucugaccgagcaacgccgcgugagugaa
gaagguuuucggaucguaaaacucuguuguuagagaagaacaaggacguu
aguaacugaacguccccugacgguaucuaaccagaaagccacggcuaacu
acgugccagcagccgcgguaauacguagguggcaagcguuguccggauuu
auugggcguaaagcgagcgcaggcgguuucuuaagucugaugugaaagcc
cccggcucaaccggggagggucauuggaaacugggagacuugagugcaga
agaggagaguggaauuccauguguagcggugaaaugcguagauauaugga
ggaacaccaguggcgaaggcggcucucuggucuguaacugacgcugaggc
ucgaaagcguggggagcaaacaggauuagauacccugguaguccacgccg
uaaacgaugagugcuaaguguuggaggguuuccgcccuucagugcugcag
caaacgcauuaagcacuccgccuggggaguacgaccgcaagguugaaacu
caaaggaauugacgggggcccgucagcucgugucgugagauguuggguua
agucccgcaacgagcgucccgggccuuguacacaccgcccgucacaccac
gagaguuuguaacacccgaagucggugagguaaccuuuuuggagccagcc
gccuaaggugggauagaugauuggggugaagucguaacaagguagccgua
ucggaaggugcggcuggauca

...<<<<..[.((((.>>>>.<<<<.<<<<<..<<<<<<<<.....<<<.
<<<..<<<..<<.<<<<<<...>>>>>>.>>>>>......<<........
<<<<<<<..<<...<<<<<<<.<.<<.....<<<<<<....>>>>>>...
...>>.>.......<<<<<<<<<..>>>>>>>>>.......<<<<<<...
.>>>>>>.>>>>>>>..>>>>>>>>>.<<<....<<<..<<<<<<<<...
....>>>>>>>>>>>......>>>..<<<<<<<<....>>>>...>>>>.
>>.<<<<<.<.........>>>>>>.<<<<<..>>>>>...>>>>>>...
......<<<....<<<<....>>>>..>>>..>>.>>>>>>..<<<<...
...<<<<....>>>>.....>>>>...<<<<<<<.........<<<<<<<
........>>>>>>>..........>>>>>>...>..<<<<<(((...<<
<<<.....<<.)))>>.......>>>>>>>>>>..>>>>>>>>>......
....<<<((.....<<<<...<<<.<<<<<<<.<<<<<<<<<.......<
<<<<<.....>>>>>>.....>>>>>>>..>>>>>>>>>...<<<<<<<<
...<<<<<<<....<<<<<<<<<..<<<......>>>.....>>>>>>>>
>...........<<....>>.>>>>>>>..>>>>>.>>>...>>>...>>
>>....<<<<<<...<<...<<<<.<.....>.>>>>...>>>>>>>>..
........<<<<<<..<<<<<<<<<<<<......>>>>>>>>>>>>...<
<..))>>.....>>>>>>.>>>.<<<......<<<<....>>>>....>>
>..)))).]<<<<<.<<<<<<....<<<<<<<<<....>>>..<<<<...
...>>>>..>>>>>>.....>>>>>>>>>.>>....<..<<.<.<<<<.<
<<..<<<<<<..<<<<...<<.<<<<..<<<..<<.....>>.>>>.>>>
>.>>..>>>>..>>>>>>..>>>.>>>>..>.>>...>.....<<<<<<<
<<....>>>>>>>>>......

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6wub Cryo-electron microscopy structure of the 70S ribosome from Enterococcus faecalis.
• Resolution: 3.2 Å
• Binding residue (original residue number in PDB): V2 T4 T12 R13 R15 N16 K31 K56 Q57 P83 Y88 K90 A91 S107 T108 S109 E126
• Binding residue (residue number reindexed from 1): V1 T3 T11 R12 R14 N15 K30 K55 Q56 P82 Y87 K89 A90 S106 T107 S108 E125

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005840 ribosome
• GO:0022627 cytosolic small ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6wub, PDBe:6wub, PDBj:6wub
• PDBsum: 6wub
• PubMed: 33004869
• UniProt: Q839F0|RS8_ENTFA Small ribosomal subunit protein uS8 (Gene Name=rpsH)