Structure of PDB 5t2a Chain h Binding Site BS01

Receptor Information
>5t2a Chain h (length=124) Species: 5661 (Leishmania donovani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCPRVQYRRRMHYATRGNRMKMVRTPGNKLVMQKRAKRSQGIHTPWVLGH
KRLGGTKALRHIDARLASRHEKSVSRAYGGVLSHDQVRDRVVRAFLVEEQ
RIVKQALKEHSKMKLSHKRTANKK
Ligand information
>5t2a Chain A (length=1603) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
caaauaucugguuggugcaggaguggcgaaauucaagcgcaaagcaaacc
cguugcugaauacaacccuucaugugaguauugagccaaagaagguguua
gcccauugagccauaaaccugagcgccucaugaagcgaguagcacuguuu
gggaaugcagugucaaguuggcagguauuugucugccaaaguuaaauaca
gaguaggaagaccgauagcgaacaaguagcgugagcgaaaguuugaaaag
cacuuuggaaagagagugaaauagaaccugaagucgugacaaagacaaug
gaaguaccuccauuucaacggccagaaccagcccuacugcauuauccugu
cgggggucaaaauccggcgggcaaaagugcaagaauuuugggucuuggug
aaaugagcggaguauuugagcugugcacggccgcacgcacugguuucuuc
uccgugaugcuccauguuggcgaugaaauggggugcccccacccgucuug
aaacacggaccaaggagucaaacagacgcgcaagggaggagauaugguug
ccaguacuucucucguacugaaagggagaugcaauaugcaucuguggugu
gcacacgucauuugcccaacaccgaccggcccuggguugcguuggagugu
gccuguuuggacccgaaagguggugaacuaugccugaacaaggugaagcc
cggggaaacccagguggaggccuguagcgaugcugacgugcaaaucgcuc
guaugauuuggguaucggagcgaaagacucaucgaaccaccuaguagcug
guucacaucgaaguuucccucaggauagcuggugcuaguagaaguauugu
gcgguaaagcaaaugauuagagggaccuauucucaaacuuuaaaugugca
aacaaaccgugccuuagccaacugcaaggccggaaagaaaagaauuagag
gcaccaagugggccuucuucgguaagcggagcaggcgaugcggaaugaac
cgcuuagggauauguggcgucaaaacuuaugggcucauucucgauacgug
aaaaggguguugguggauaaauccaccggccccgaaaauggaugacgcuu
aagcccaauuagugguugcccauuauuccuuugguaagggcggaaacaaa
cggagaaaguguagcccuuccgauguagauguggccuggagguuaggacg
aagcuuauggcgugagccuaagauggaccggccucuagugcagaucuugg
uuggcguagcaaagaucuaacggagauauacaacaugcaacguuggauac
uggagcggggaaggauuucgugccaacggcacucguacacgaguuguucg
gaaacugagcacaacguuauaucguuuuguuaggaaagugaagguacuga
aaaggggcaacagagaaccugggauuauauuccaaaaagaaauugcaugu
ggg
......................<<<<<......<......>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<...<<<<<<<......>>>>>.>>.....>>>>
..........<..<<....<<....<......<<<<......<<<<....
...>>>>.....<<........>>......>>>><<.......((.....
>>)).......>......>>......>>>............<<<<<<<..
......>>>>>>>......<<<<<........>>>>>..>>>........
............................<<....>>..............
..<<<<....>>>>..................................((
(..<<<<<<.<<<<<<..((.<<<<.<<<<<<<<....<<<<<..<<<<<
<<<<........>>>>>>>>>...>>.>>>.........>>>>..>>>>.
.......<<<<<.....<<...<<<..<<..>>....>>>...>.>...>
>>>>.....<<<<...>>>>))..>>>>>>>>>>>>..))).<<<<....
....>>>><<<<<<....<<<<<<<.<<<<<..<<<...<<.<.......
.....>>>...>>>...<<....>>..<<<<<.....>>>>>...<<<<<
...<<.<<.>>.>>....>>>>><<<<<<<<<.>>>>>>.>>>...>>>>
>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<
.<<<....>>>.>>>.....>>>...<<<..<<.<<........>>>>.>
>>....>>>>>>>>>...<<.......>>......>>>>>>...>..>.>
>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<<...<<<<
<<<...<<<....<<<....<<<..>>>....>>>..>.>>...>>>>>>
>.....<<<.<<<<<.<<.....>>>>>>>>>>...........>>...>
>>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>...<<<<......>
>>>..<<<<<<<...<<<(((......<..<<<<........<.......
....<<<.<<<<<<<<<<..>>>>>>>>>>>>>..........))).>..
..>>>>.>.........>>>...>>>>>>>((((.<<<<<..........
.>>>>.........>>>>>))))....>>>>>....<<<<<<<<......
...<<<..<<<....>>>.>>>.......>>>>>>>>........>>>>>
>..............<<<<<<<..................>>>>>>>...
.................<<<<<....<<.....>>..>>>>>....<<..
........<<.<<<<<......>>>>...............<<...>>..
....>.>>..........<<<...........>....>>.>>........
...
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5t2a Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		C3 R5 Q7 R9 R11 M12 H13 Y14 T16 R17 T26 G28 Q34 K38 R61 R66
Binding residue
(residue number reindexed from 1)		C2 R4 Q6 R8 R10 M11 H12 Y13 T15 R16 T25 G27 Q33 K37 R60 R65
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5t2a, PDBe:5t2a, PDBj:5t2a
PDBsum5t2a
PubMed27752045
UniProtA0A3Q8IHK2

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