Structure of PDB 7pwo Chain g2 Binding Site BS01

Receptor Information
>7pwo Chain g2 (length=99) Species: 184922 (Giardia lamblia ATCC 50803) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ADCRVTCRFHSTYRTRSKIVRYKRTPGNRLTSLRVKKLPNAPHCAETGKQ
IHGIPRVIPQHLTRQQRKVSRPYGGKLCGSALRAHILESFLNEENQALR
Ligand information
>7pwo Chain 1 (length=2448) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguacgc
cccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcggga
ggagcccgccccgaaggcgcgcugugggcgccgcgagggggcccgagggc
cccgcccgagagggugcaagccccguacggcgggcgaguagcgcugcuug
agcgugcagcgcgaagggaggcgcggcccuuccaaggcuaaauacgcccc
gggaccgauagcggaccaaguagcgcgagcgaacggugaaaaggacgccc
ggccgcucaaaagaccugaacccggccggcgccggcccgccggccccguc
ucgaaacacggaccgaggagccacgcgccgcggcgagcccgagggccccg
cggcggagcgagcgcgagacgccccgggcccgccgcgccccugcgggcgu
gcgcgggccgagccgcggcgcgugggcccgaaaggcggugaucuaugccc
ggcgagggcgaggccgggcgaaagccugguggaggcccgccgcggugcug
acgcgcagaucgcucgucggagccgggcaugggggcgaaagacucaucga
accgccugguagcugguugccuccgaaaugucucccaggacagccgccgc
ccgcaguugcggcccguagagcgcuggccggcggccgccccccaaacucc
gaagggccgcgccgccccgcccuggccugggcggggcgggcgaaugcggg
cggcgcgugggccccuccugguaagcaggacgggcgaggcgggacgaucc
ggacgccgggccagggugcgccgccggggccggaacggcgucggccgcgg
ccggcccggaaaauggagcgcgccggagccccggacccgcgcccggccgc
cgcgcgcggcggguaggaggccgcagaggccccgggggcgaaggcggcgc
gcaggccccgccggaccggccucuggugcagaucucggcagcaguagcgc
uacuccgcccccggaggacugagggggagacggguuccgcggcgccugca
ucuggccgcgggugacucgggccuaagcggcgggugaagaccgggaaggg
gcgugcccgcccgucgaacggggagccggcggagacuccggcaggcgcgg
gcggagacgcgccccccggcgacgcgcacggggaccgcggcgggcggcgc
cccggcccgcgaacgccccgcagcccccggacgccuugcgcggagagggg
ggcccgggggcggaccgcgcguccccggccgccccugaaaagccgggggg
cccgcgcgccguaccgaccgcacaggacuccggggucagcagccucuagc
gcgggagcgaacgcggcucagggaagucggcaagccggcuccguaaccuc
gggaaaaggaguggcucugacggggucagaacuggaacggacgcggggau
cccgacuguuuacuagaaacacagcgucgcgagggccgcacccggcgcug
gcgcgacgugauuucugcccagugccagaccgucaccgugaagcgauccg
ccgaagcccugguaaacggcgggaguaaugacucucuuaagguagccaaa
ugccucgucgggcaauuuccgacggcaugaauggaccaacgaggauccca
cugucccgagccgcgccuccgcgagccuccagccucgggaacgggcgagg
gccggccagcggggcaagaagacccuuuugagcuugacuccagcccgggc
cuguggggcggggccgccccgcucacccggucgcgcggggacccgcccgg
gcggggaguucggcuggggcggcgcgccugcuacaccggaccgcaggcgu
cccacggcgggcucagcgaggacccucccgcggagcagaagggcacaagc
ccgcccgacccgcgccccccgugccggcgcgggccgcgaaagcggggccu
accgauccuucgccgccccggccgcgggcgcggagguggcagaaaaguua
ccacagggauaacuggcuuguggccgccgagcgcccgcagcgacgcggcu
uuuugauccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcg
gaagcgucggauuguucacccguucaagggaucgugagcuggguuuagac
cgucgugagacgguuaguuuuacccuacuggccccggggccagagcacgg
cgggccaguacggaggaacgcccgccgcgggcgcccagccccgcgguugc
ccgccggggcagaccgcgcgcccgggcccgggggccuggcgcugccgccu
cuaaagcgccaccccccccuccggccccgccgcccgcgccccagccccgu
gcccccugcccgaggcggcccccgcccgggaggaccacccggcgcggcgc
cccuguacggcgagggcgcguucgcccggggggcgcgccgcaggcgcg
......................<<<<<<.....<......>......>>>
>>.>.........<<....>>..<<<<<....<<.....>>.....>>>>
>..[[[...<<<<...........>>>><<<<..<..<<<<<......>>
>>>((......<<<.....))>>>...>>>>>........<<<<<<<...
.....>>>>>>>...(((((..<<<<<<)))))..]]]............
......................<<....>>................<<<.
>>>...........................<<<<<<..>>>>>>.<<<<.
.......>>>>.<<<<<....<<<<<<<<<<<<<..<<<...<<<.>>>.
.>>>...<<....>>............<<<<<<<<<<<<<....>>>>>>
>.>>>>>>...>>>>>>>>>>>>>..<<.<..<<<<<<<.....<<<<<<
<<<..<<<....<<<<<<<....>>>>>>>.....>>>...<<<..<<.<
<........>>>>.>>>....>>>>>>>>>...<<.......>>......
>>>>>>...>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<
<<<<<.<<<<<<<<<...<<<...<<<..<<<<..>>>>..>>>..>>.>
...>>>>>>>.<<<<<<<<<<<......>>>>>>>>>>>...>>>>>>>>
>>>>>.>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>
>...<<<<<<<..<<<<(((...<<<<<<<.....<<<.<<<<<<<..>>
>>>>>>>>..........)))......>>>>>>>>>>>..>>>>>>><<<
<<<..>>>>>>....>>>>>><.<<<<<<<<...<<......<<<<<.<<
....>>.>>>>>...>>>>>>>>>>..>.....>>>>>.<<.....<<..
..<<<<<....>>>>>..<<.....<<<<..<<...<<<<<<...<....
...>.>>>>>>....((<<<.<<...<<<...<<<....>>>......<<
<<..>>>>...>>.>....>>...<<<<<........>>>>>))<<<<<<
<<<....>>><<<<<<<<<<...<<<..<<<<<<<<<<<<<<<<<.....
....>>>>>....<<<<<<...<<<<<<....<<.....>>......>>>
>>>...>>>>>>..>>>>>.>>>>>>>..>>>.........>>>>>>>>>
>>>>>>>.>>>..>>..<<.....>>.>>>>.<<<<.....>>>>..>>.
...<<<<....<<<<<<<<.<<.........<.....<<<<<....<<..
>>.....>>>>><<.<<<<<<...>>>>>>.>>............<<<<<
<<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>....
..>>>>>>>...<<..<<<..<<<<<<<...<<....<<<.<....>.>>
>....>>.>>>>>..>>>>><<<<<<....>>>>>>........<.....
......<<<<<<.....>>>>>>....>.....>>....>>.>>>>>>>.
.>..>>.>>>>>>>>.>>>>>>....>>....<<<<<........>>>>>
...((((((..{{{.........{{{..{{[[[[..<<<<<.<<<<<<<<
..<<<<<<<<<..>>>>>>>>>...<<<<......>>>>.....>>>>>>
>>..>>>>>...<<<.....>>>..<<<<<<...........>>>>>>..
<<...<<<<<<<...<.<<<<..>>>>.>.....<<...(((>>....>>
>>>>>...<<<<<<<<.........>>>>>>>>.<<<....>>>.>>)))
.......((((((.((((.>>>>>>))))))))))..........]]]].
.}}.}}}.......<<.<.<.<<<<<<...<<.......>>...>>>>>>
...>>.>.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>
>..>>>.<<<.........>>>....>>>>>..>...>>>.>>....<<<
<<<<....>>>>>>>........}}}.))))))..<<<<<<.<<<..<<<
<<<<<..............>>>>>>>><<<<<...<.<....<<<<<<<<
<<....>>>>>.>>>>>....>.>.>>>>>.<<<...<<<<<<.......
....>>>>>>...>>>..>>>.>>>>>>...<.<<<..............
...............>>>.>...<<.<<<<.......>>>>..<<<<<<<
<<<<....<<<<<<.<..>.>>>>>>...>>>>.>>>>>>>....>>.
Receptor-Ligand Complex Structure
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PDB7pwo Cryo-EM structure of the ancient eukaryotic ribosome from the human parasite Giardia lamblia.
Resolution2.75 Å
Binding residue
(original residue number in PDB)		R5 V6 T7 R9 H11 S12 T13 Y14 R15 T16 R17 S18 K19 Y23 R25 T26 P27 G28 N29 T32 K37 K38 L39 N41 P43 H44 H53 G54 R57 Q61 H62 R65 Q66 R68 S71 R72 Y74 K77
Binding residue
(residue number reindexed from 1)		R4 V5 T6 R8 H10 S11 T12 Y13 R14 T15 R16 S17 K18 Y22 R24 T25 P26 G27 N28 T31 K36 K37 L38 N40 P42 H43 H52 G53 R56 Q60 H61 R64 Q65 R67 S70 R71 Y73 K76
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pwo, PDBe:7pwo, PDBj:7pwo
PDBsum7pwo
PubMed35100413
UniProtA8BMF7

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