Structure of PDB 7nwg Chain g2 Binding Site BS01

Receptor Information

>7nwg Chain g2 (length=68) Species: 9986 (Oryctolagus cuniculus)

KSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFM
ASHFDRHYCGKCCLTYCF

Ligand information

>7nwg Chain A2 (length=1740)

uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucagaucaaaaccaacccggucaggcggcuuuggugac
ucuagauaaccucgggccgaucgcacgcccggcggcgacgacccauucga
acgucugcccuaucaacuuucgaugguagucgccgugccuaccaugguga
ccacgggugacggggaaucaggguucgauuccggagagggagccugagaa
acggcuaccacauccaaggaaggcagcaggcgcgcaaauuacccacuccc
gacccggggagguagugacgaaaaauaacaauacaggacucuuucgaggc
ccuguaauuggaaugaguccacuuuaaauccuuuaacgaggauccauugg
agggcaagucuggugccagcagccgcgguaauuccagcuccaauagcgua
uauuaaaguugcugcaguuaaaaagcucguaguuggaucuugggagcggg
cggccguccguccccugccucucggcgccccggggcccgaagcguuuacu
uugaaaaaauuagaguguucaaagcaggccgccuggauaccgcagcuagg
aauaauggaauaggaccgcgguucuauuuuguugguuuucggaacugagg
ccaugauuaagagggacggccgggggcauucguauugcgccgcuagaggu
gaaauucuuggaccggcgcaagacggaccagagcgaaagcauuugccaag
aauguuuucauuaaucaagaacgaaagucggagguucgaagacgaucaga
uaccgucguaguuccgaccauaaacgaugccgacuggcgaugcggcggcg
uuauucccaugacccgccgggcagcuuccgggaaaccaaagucuuugggu
uccggggggaguaugguugcaaagcugaaacuuaaaggaauugacggaag
ggcaccaccaggaguggagccugcggcuuaauuugacucaacacgggaaa
ccucacccggcccggacacggacaggauugacagauugauagcucuuucu
cgauuccgugggugguggugcauggccguucuuaguugguggagcgauuu
gucugguuaauuccgauaacgaacgagacucuggcaugcuaacuaguuac
gcgaccccggucggcguaacuucuuagagggacaaguggcguucagccac
ccgagauugagcaauaacaggucugugaugcccuuagauguccggggcug
cacgcgcgcuacacugacuggcucagcgugugccuacccuacgccggcag
gcgcggguaacccguugaaccccauucgugauggggaucggggauugcaa
uuauuccccaugaacgaggaauucccaguaagugcgggucauaagcuugc
guugauuaagucccugcccuuuguacacaccgcccgucgcuacuaccgau
uggaugguuuagugaggcccucggaucggccccgccggggugcccuggcg
gagcgcugagaagacggucgaacuugacuaucuagaggaaguaaaagucg
uaacaagguuuccguaggugaaccugcggaaggaucauua

...<<<<<...(((.>>>>><<<.<<<<<<...<.<<..<......<<..
<<<..<<....<.......................>.>>......<<...
.....<<<.<..........<<<...........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<......>>>>>..
.>>>><<..<<<<<.......(((.....<........>......<....
.>..>>>>>......>>...<<<<..<.....>.>>>>....>>>.....
..>.>>>.<<<....<<<....<<<<<<<.........>>>>>>>>>>..
....>>>....<<.<<<<....>>>>....>>..>>.<<.<<.<......
...>>>.>>...<<....>>.....>>>.>>.........<<<....<<<
.....>>>..>>>..>...>>.>.....<<<.<<<<..<<<....>>>..
.>>>>..>>>......<<..<...........>..>>.........<<<<
<((....<.<<<<.....<<..))>>.......>>>>>>>>>>..>>>>>
>.>>>...........<[[.....<.<<...<<<.<<....<<<.<<<<.
<<..>>.>>>>.>>>....<........<<..>.>.....>....<<<<<
<.<.......<<...<.......>.<<<<.>>>>...>>......>.>>>
..>>>..........<<.<<<<<<<.........)))...>>>>>>>.>>
......>>....<<<<<<......<<<<...<..<<<<<<<<...<<<..
....>>>......>>>>>>>>..>........<<....>>...>>>>...
..>>>.>>>...>>>...>>.>....<<<<<<<...<...<<<<.<....
.>.>>>>...>>>>>>>>..........<<<.<<.<<<..<.<<<<<<.<
<<<......>>>>>>>>>>.>..>>>...<<..]]>>...>>.....>>>
.>...<<<......<<<......>>>....>>>...)))..<<<<<.<<<
<<<<..<<..<<<<...<<<.<<<<<<......<<........>>.....
.....<<.<<......<<..<<.......<<.<<<........>>>.>>.
....>>..>>...<..<<<..<<.<<<<<.....<<<.<<<<......>>
...<<<......>>>...>>.>>>....<<<...<...<<<<..<<<<<<
<.<.<....>>...>>>>>>>..>>>>..>.....<<<<<.....>>>>>
........>>>.....>>.>>>.....>>>>>.>.......>>.>>...>
>.>>>>.>>>.....<<.<<<................<<<.<<<<....>
>>>.>>>..............>>>.>>.............<<<<......
....>>>>.............>>>>.....<<<<<<<<.......>>>>>
>>>......>>...>>>>>>>>>>.>>....<..<<.<..<<<<..<...
.<<<<<<<<.<<<..<<.<<<<...<<<<<.<<<<<<<<<..>>>>>>>>
>...>>>>>...>>.>>>>..>>>.>>>>>>>>...>..>>>>...>.>>
...>.....<<<<<<<<<....>>>>>>>>>.........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 7nwg Blasticidin S inhibits mammalian translation and enhances production of protein encoded by nonsense mRNA.
• Resolution: 3.8 Å
• Binding residue (original residue number in PDB): Y85 P88 K89 K92 R95 K99 L100 H135 R138 Y140 K143
• Binding residue (residue number reindexed from 1): Y3 P6 K7 K10 R13 K17 L18 H53 R56 Y58 K61

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome

External links

• PDB: RCSB:7nwg, PDBe:7nwg, PDBj:7nwg
• PDBsum: 7nwg
• PubMed: 34157102
• UniProt: G1SK22|RS27A_RABIT Ubiquitin-ribosomal protein eS31 fusion protein (Gene Name=RPS27A)