Structure of PDB 8sho Chain g Binding Site BS01

Receptor Information
>8sho Chain g (length=526) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPM
GGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGE
MLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDISDSDMMLN
IINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIKKYARVEKI
PGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQT
DIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYL
MRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKK
IGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLD
PQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQN
CGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQ
TYKTAVETAVLLLRIDDIVSGHKKKG
Ligand information
Ligand IDADP
InChIInChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKeyXTWYTFMLZFPYCI-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)OP(=O)(O)O)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
ACDLabs 10.04O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P@@](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)O)O)N
FormulaC10 H15 N5 O10 P2
NameADENOSINE-5'-DIPHOSPHATE
ChEMBLCHEMBL14830
DrugBankDB16833
ZINCZINC000012360703
PDB chain8sho Chain g Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8sho Visualizing the chaperone-mediated folding trajectory of the G protein beta 5 beta-propeller structure
Resolution3.0 Å
Binding residue
(original residue number in PDB)		G42 P43 D93 G94 T95 T96 T162 G410 G411 G482 I495 E497
Binding residue
(residue number reindexed from 1)		G38 P39 D89 G90 T91 T92 T158 G406 G407 G478 I491 E493
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0044183 protein folding chaperone
GO:0051082 unfolded protein binding
GO:0140662 ATP-dependent protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0007339 binding of sperm to zona pellucida
GO:0032212 positive regulation of telomere maintenance via telomerase
GO:0050821 protein stabilization
GO:0051086 chaperone mediated protein folding independent of cofactor
GO:0061077 chaperone-mediated protein folding
GO:1904871 positive regulation of protein localization to Cajal body
GO:1904874 positive regulation of telomerase RNA localization to Cajal body
Cellular Component
GO:0002199 zona pellucida receptor complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005832 chaperonin-containing T-complex
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0044297 cell body
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8sho, PDBe:8sho, PDBj:8sho
PDBsum8sho
PubMed37852256
UniProtP49368|TCPG_HUMAN T-complex protein 1 subunit gamma (Gene Name=CCT3)

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