Structure of PDB 8rbx Chain g Binding Site BS01

Receptor Information
>8rbx Chain g (length=886) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLAD
VFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARA
ITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSK
DFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQ
LVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKR
LAIQDLKLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLSTLSG
TIAIKHYFRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLA
LEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVV
ETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGRS
ATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIAR
QASRMGNHDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEE
NYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAF
SQLICTCNSLKTSPPPAIALQRCGRISNQMKQSMEEFRSLASRYGDLYQA
SFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGTAHAD
SEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIIALLKVPLSF
QRYFFQKLQSTSIKLALSPPIAVQNNQQLALKVEGVVQHGSKPGLFRKIQ
SVCLNVSSTLQSNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESS
VKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQ
Ligand information
Receptor-Ligand Complex Structure
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PDB8rbx Structural basis of Integrator-dependent RNA polymerase II termination
Resolution4.1 Å
Binding residue
(original residue number in PDB)		R73 K105 V110 H112 S113 N114
Binding residue
(residue number reindexed from 1)		R53 K85 V90 H92 S93 N94
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint signaling
GO:0006974 DNA damage response
GO:0016180 snRNA processing
GO:0034243 regulation of transcription elongation by RNA polymerase II
GO:0034472 snRNA 3'-end processing
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0016604 nuclear body
GO:0032039 integrator complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8rbx, PDBe:8rbx, PDBj:8rbx
PDBsum8rbx
PubMed38570683
UniProtQ9NVH2|INT7_HUMAN Integrator complex subunit 7 (Gene Name=INTS7)

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