Structure of PDB 8fru Chain g Binding Site BS01

Receptor Information
>8fru Chain g (length=97) Species: 941442 (Giardia intestinalis assemblage A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MADCRVTCRFHSTYRTRSKIVRYKRTPGNRLTSLRVKKLPNAPHCAETGK
QIHGIPRVIPQHLTRQQRKVSRPYGGKLCGSALRAHILESFLNEENQ
Ligand information
>8fru Chain 1 (length=2551) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcggcccgaggcggcgggggcgacgggcggaacuuaagcauaucaguac
gccccggaggagaaaccaaccgggauuccccguagcggcgagcgacgcgg
gaggagcccgccccgaaggcgcgcuguggggcgcaccgccgcgagggggc
ccgagggccccgcccgagagggugcaagccccguacggcgggcggcgagu
agcgcugcuugagcgugcagcgcgaagggaggcgcggcccuuccaaggcu
aaauacgccccgggaccgauagcggaccaaguagcgcgagcgaacgguga
aaaggacgcccugcggccgcucaaaagaccugaacccggccggccgccgg
cccgccggccccgucucgaaacacggaccgaggagccacgcgccgcggcg
agcccgagggagcccccgcggcggagcgagcgcgagacgccccgggcccg
ccaugccccugcgggcgugcgcgggccgagccgcggcgcgugggcccgaa
aggcggugaucuaugcccggcgagggcgaggccgggcgaaagccuggugg
aggcccgccgcggugcugacgcgcagaucgcucgucggagccgggcaugg
gggcgaaagacucaucgaaccgccugguagcugguugccuccgaaauguc
ucccaggacagccgccgccccgcaguugcggcccguagagcgcuggccgg
cgggagcggggccucgcccgccccccaaacuccgaagggccgcgccgccc
cgccgcuggccugggcggggcgggcgaaugcgggcggcgcgugggccccu
ccugguaagcaggacgggcgaggcgggacgauccggacgccgggccaggg
ugcgccgccggggcccgcggaacggcgucggccggucccgacagcagccg
aaucggccggcccggaaaauggagcgcgccggagccccggacccgcgccc
ggccgccgcgcgcggcggguaggaggccgcagaggccccgggggcgaagg
cggcgcgcaggccccgccggaccggccucuggugcagaucucggcagcag
uagccgcuacuccgcgccccggaggacugagggggagacggguuccgcgg
cgccugcaucuggccgcgggugacucgggccuaagcggcgggugaagacc
gggaaggggcgugcccgcccgucgaacggggagccggcggagacuccggc
aggcgcggcccccgcggagacgcccgccccccggcgacgcgcacggggac
cgcggcgggcggcgccccggcccgcgaacgccccgcagcccccggacgcc
uugcgcggagaggggggcccgggggcggaccccgcgcguccccggccgcc
ccugaaaagccggggggcgccggccgcgcgccguaccgaccgcagcagga
cuccggggucagcagccucuagcgcgggagcgaacgcggcucagggaagu
cggcaagccggcuccguaaccucgggaaaaggaguggcucugacggccgg
gucagaacuggaacggacgcggggaucccgacuguuuacuagaaacacag
cgucgcgagggccgcacccggcgcuggcgcgacgugauuucugcccagug
ccacgaccgucaccgugaagcgauccgccgaagcccugguaaacggcggg
aguaacuaugacucucuuaagguagccaaaugccucgucgggcaauuucc
gacgugcaugaauggaccaacgaggaucccacugucccgagccgcgccuc
cgcgagccuccagccucgggaacgggcgagggccggccagcggggcaaga
agacccuuuugagcuugacuccagcccgggccuguggggcgggggccgcc
gccgccccgcucacccggucgcgcggggacccgcccgggcggggaguucg
gcuggggcggcgcgccugcuacaccggaccgcaggcgucccacggcgggc
ucagcgaggacggagaccucccgcggagcagaagggcacaagcccgcccg
acccgcgccccccgugccggcgcgggccgcgaaagcggggccuaccgauc
cuucgccgccccggccgcgggcgcggagguggcagaaaaguuaccacagg
gauaacuggcuuguggccgccgagcgcccgcagcgacgcggcuuuuugau
ccuucgaugucggcucuuccuaccguccgcgcgcaccggcgcggaagcgu
cggauuguucacccguucaagggaucgugagcuggguuuagaccgucgug
agacagguuaguuuuacccuacuggccccggggccagagcacggcgggcc
aguacgagaggaacgcccgccgcgggccgccagccccgcgguugcccggc
cgggcagcgccgcgccgccgcgcccgggggcccugcgcugaccgccucua
agcgcgcaccccgccucgcgccccgcccggccgcgcgccccagccccgug
ccccgucgccgagcggcccccgcccggggagaccacccggcgcggcgcuc
cuguacggcgcagagcccugcgaucgccugagggacgcgccugcagagcg
c
........................<<<<<<.....<......>......>
>>>>.>.........<<....>>..<<<<<....<<.....>>.....>>
>>>..[[[...<<<.............>>><<...<<<<<<....<<<<<
......>>>>>((......<<<.....))>>>...>>>>>>>>.......
.<<<<<<<........>>>>>>>...(((((..<<<<<<)))))..]]].
.................................<<....>>.........
.......<<<....>>>............................<<<<<
<..>>>>>>.<<<<........>>>>.<<<<<....<<<<<<<<<<<<<.
.<<<...<<<....>>>..>>>...<<....>>............<<<<<
<<<<<<<<....>>>>>>>.>>>>>>...>>>>>>>>>>>>>..<<.<..
<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>>>>..
...>>>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>..
.<<.......>>......>>>>>>...>..>.>>..<<<<<<....<<<<
<....>>>>><<<<<<<<<<.<<<.<<<<<<<<<...<<<...<<<..<<
<<<..<<<<<..>>>>>>>>>>..>>>..>>.>...>>>>>>>.<<<<<<
<<<<.........>>>>>>>>>>...>>>>>>>>>>>>>.>>..<<<<.<
<<<<.....>>>>>.>>>>....<<<......>>>...<<<<<<<..<<<
<(((...<<<<<<<........<<<.<<<<<<<<<...............
..>>>>>>>>>>>>..........)))......>>>>>>>>>>>..>>>>
>>><<<<<....>>>>>....>>>>>><<<<<<<<<<...<<......<<
<<<.<<....>>.>>>>>...>>>>>>>>>>.>>.....>>>>>.<<...
..<<.....<<<<<.....>>>>>..<<.....<<<<..<<...<<<<<<
...<.......>.>>>>>>....((<<<.<<...<<<...<<<....>>>
......<<<<..>>>>...>>.>....>>...<<<<<........>>>>>
))<<<<<<<<...<<<....>>>..<<<<<<<<<<...<<<..<<<<<<<
<<<<<<<<<<...{{{...>>>>>....<<<<<<...<<<<<<....<<.
....>>......>>>>>>...>>>>>>....>>>>>.>>>>>>>..>>>.
........>>>>>>>>>>...>>>>>>>>.>>>..>>..<<......>>.
>>>>.<<<<.....>>>>..>>....<<<<....<<<<<<<<.<<.....
....<.....<<<<<....<<..>>.....>>>>><<.<<<<<<......
>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<
<<<<<<....<<<<....>>>>......>>>>>>>...<<..<<<..<<<
<<<.<...<<....<<<.<....>.>>>....>>.>>>>>..>>>>><<<
<<<.......>>>>>>........<...........<<<<<<.....>>>
>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>>.>>>
>>>....>>....<<<<<........>>>>>...((((((..{{{.....
....{{{..{{[[[[..<<<<<.<<<<<<<<..<<<<<<<<<........
.>>>>>>>>>...<<<<......>>>>.....>>>>>>>>..>>>>>...
<<<.....>>>..<<<<<<...........>>>>>>..<<...<<<<<<<
...<.<<<<.......>>>>.>.....<<...(((>>....>>>>>>>..
.<<<<<<<<.........>>>>>>>>.<<<....>>>.>>))).......
(((((.(((((.>>>>>>))))))))))..........]]]]..}}.}}}
.......<<.<.<.<<<<<<...<<.......>>...>>>>>>...>>.>
.>.......<<<<<.<<<<<<..<<<<<<<<<......>>>>>>..>>>.
<<<.........>>>....>>>>>..>...>>>.>>....<<<<<<<...
.>>>.>>>>........}}}.))))))..<<<<<..<<<..<<<<<<<<.
..............>>>>>>>><<<<<...<.<<...<<<<<<<<<<}}}
.>>>>>..>>>>>...>>.>.>>>>>.<<<...<<<<<<...........
>>>>>>...>>>..>>>..>>>>>....<<<<<<................
............>>>>>>.....<<<<<.......>>>>..<<<<<<<<<
<<....<<<<.<..<<...>>..>>>>>...>>>>.>>>>>.>>...>..
.
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8fru The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function.
Resolution2.49 Å
Binding residue
(original residue number in PDB)
A2 D3 R5 V6 T7 R9 H11 S12 T13 Y14 R15 R17 S18 Y23 K24 R25 T26 P27 G28 N29 R30 T32 K37 K38 L39 N41 P43 K50 H53 G54 P60 Q61 H62 R65 Q66 R68 S71 R72 P73 G75
Binding residue
(residue number reindexed from 1)
A2 D3 R5 V6 T7 R9 H11 S12 T13 Y14 R15 R17 S18 Y23 K24 R25 T26 P27 G28 N29 R30 T32 K37 K38 L39 N41 P43 K50 H53 G54 P60 Q61 H62 R65 Q66 R68 S71 R72 P73 G75
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
GO:0042254 ribosome biogenesis
Cellular Component
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:8fru, PDBe:8fru, PDBj:8fru
PDBsum8fru
PubMed38242118
UniProtA8BMF7

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