Structure of PDB 7pfa Chain g Binding Site BS01

Receptor Information
>7pfa Chain g (length=109) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLP
NIQAVLLPK
Ligand information
>7pfa Chain I (length=561) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggccgccatactggagaatcccggtgccgaggccgctcaattggtcgtag
acagctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgtttta
accgccaaggggattactccctagtctccaggcacgtgtcagatatatac
atcctgtcatgtaagtattaaggtaacccagtactgtctcgcgcactggc
cgccatactggagaatcccggtgccgaggccgctcaattggtcgtagaca
gctctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaacc
gccaaggggattactccctagtctccaggcacgtgtcagatatatacatc
ctgtcatgtaagtattaaggtaacccagtactgtctcgcgcactggccgc
catactggagaatcccggtgccgaggccgctcaattggtcgtagacagct
ctagcaccgcttaaacgcacgtacgcgctgtcccccgcgttttaaccgcc
aaggggattactccctagtctccaggcacgtgtcagatatatacatcctg
tcatgtaagta
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB7pfa Histone H1 binding to nucleosome arrays depends on linker DNA length and trajectory.
Resolution9.7 Å
Binding residue
(original residue number in PDB)		R11 R35 R42 V43 G44 A45 K75 T76 R77
Binding residue
(residue number reindexed from 1)		R2 R26 R33 V34 G35 A36 K66 T67 R68
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0030527 structural constituent of chromatin
GO:0031492 nucleosomal DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006325 chromatin organization
GO:0008285 negative regulation of cell population proliferation
GO:0031507 heterochromatin formation
GO:0061644 protein localization to CENP-A containing chromatin
Cellular Component
GO:0000786 nucleosome
GO:0005634 nucleus
GO:0005694 chromosome
GO:0043505 CENP-A containing nucleosome
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7pfa, PDBe:7pfa, PDBj:7pfa
PDBsum7pfa
PubMed35581345
UniProtP04908|H2A1B_HUMAN Histone H2A type 1-B/E (Gene Name=H2AC4)

[Back to BioLiP]