Structure of PDB 6tnn Chain g Binding Site BS01

Receptor Information

>6tnn Chain g (length=119) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

SYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVVEKMITLG
KRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRI
MKLGPRRGDGAPMAIIELV

Ligand information

>6tnn Chain U (length=2930)

acgguuaaguuagaaagggcgcacgguggaugccuuggcacuaggagccg
augaaggacgggacgaacaccgauaugcuucggggagcuguaagcaagcu
uugauccggagauuuccgaauggggaaacccaccacucguaauggagugg
uauccauaucugaauucauaggauaugagaaggcagacccggggaacuga
aacaucuaaguacccggaggaagagaaagcaaaugcgauucccugaguag
cggcgagcgaaacgggaucagcccaaaccaagaggcuugccucuuggggu
uguaggacacucuguacggaguuacaaaggaacgagguagaugaagaggu
cuggaaaggcccgccauaggagguaacagcccuguagucaaaacuucguu
cucuccugaguggauccugaguacggcggaacacgugaaauuccgucgga
auccgggaggaccaucucccaaggcuaaauacucccuagugaccgauagu
gaaccaguaccgugagggaaaggugaaaagcaccccggaaggggagugaa
agagauccugaaaccgugugccuacaaguagucagagcccguuaacgggu
gauggcgugccuuuuguagaaugaaccggcgaguuacgaucccgugcaag
guuaagcagaagaugcggagccgcagcgaaagcgagucugaauagggcgc
augaguacguggucguagacccgaaaccaggugaucuacccauguccagg
gugaaguucagguaacacugaauggaggcccgaacccacgcacguugaaa
agugcggggaugagguguggguaggggugaaaugccaaucgaaccuggag
auagcugguucucuccgaaauagcuuuagggcuagccucaagguaagagu
cuuggagguagagcacugauuggacuaggggccccuaccggguuaccgaa
uucagucaaacuccgaaugccaaugacuuauccuugggagucagacugcg
agugauaagauccguagucgaaagggaaacagcccagaccgccagcuaag
gucccaaaguauacguuaaguggaaaaggauguggaguugcuuagacaac
caggauguuggcuuagaagcagccaccauuuaaagagugcguaauagcuc
acuggucgagugacucugcgccgaaaauguaccggggcuaaacguaucac
cgaagcugcggacuguucuucgaacagugguaggagagcguucuaagggc
ugugaagccagaccggaaggacugguggagcgcuuagaagugagaaugcc
gguaugaguagcgaaagaggggugagaauccccuccaccgaaugccuaag
guuuccugaggaaggcucguccgcucaggguuagucgggaccuaagccga
ggccgaaaggcguaggcgauggacaacagguugauauuccuguaccaccu
ccucaccauuugagcaauggggggacgcaggaggauaggguaagcgcggu
auuggauauccgcguccaagcaguuaggcugggaaauaggcaaauccguu
ucccauaaggcugagcugugauggcgagcgaaauauaguagcgaaguucc
ugauuccacacugccaagaaaagccucuagcgaggugagaggugcccgua
ccgcaaaccgacacagguaggcgaggagagaauccuaaggugaucgagag
aacucucguuaaggaacucggcaaaaugaccccguaacuucgggagaagg
ggugcucuguuagggugcaagcccgagagagccgcagugaauaggcccag
gcgacuguuuagcaaaaacacaggucucugcgaagccguaaggcgaagua
uaggggcugacgccugcccggugcuggaagguuaagaggagcgcuuagcg
uaagcgaaggugcgaauugaagccccaguaaacggcggccguaacuauaa
cgguccuaagguagcgaaauuccuugucggguaaguuccgacccgcacga
aaggcgcaacgaucugggcacugucucaacgagagacucggugaaauuau
aguaccugugaagaugcagguuacccgcgacaggacggaaagaccccgug
gagcuuuacugcagccugauauugaauguugguacagcuuguacaggaua
gguaggagccuuggaaaccggagcgccagcuuugguggaggcaucggugg
gauacuacccuggcuguauugaccuucuaacccgccgcccuuaucgggcg
gggagacagugucaggugggcaguuugacuggggcggucgccuccuaaaa
gguaacggaggcgcccaaagguucccucagaaugguuggaaaucauucgc
agaguguaaaggcacaagggagcuugacugcgagaccuacaagucgagca
gggacgaaagucgggcuuagugauccggugguuccgcauggaagggccau
cgcucaacggauaaaagcuaccccggggauaacaggcuuaucucccccaa
gaguccacaucgacggggagguuuggcaccucgaugucggcucaucgcau
ccuggggcuguagucggucccaaggguugggcuguucgcccauuaaagcg
guacgcgagcuggguucagaacgucgugagacaguucggucccuauccgu
cgcgggcgcaggaaauuugagaggagcuguccuuaguacgagaggaccgg
gauggacgcaccgcugguguaccaguuguucugccaagggcaucgcuggg
uagcuaugugcggacgggauaagugcugaaagcaucuaagcaugaagccc
cccucaagaugagauuucccauuccgcaaggaaguaagaucccugaaaga
ugaucagguugauaggucugagguggaaguguggcgacacauggagcuga
cagauacuaaucgaucgaggacuuaaccau

..<<<<<<<<......<<<<<<<<<<<....{[[..[[<<<<<<<[[<<.
.....<<<<<<.....((.>>>.....<<<<<<<..<<.))......>>.
....>>>>>>>...>>>....<<<....>>><<<<<<<......>>>>>>
>.<<<<<<<<<.........>>>>>>>.>>.>>....<<<<<<.....<<
....>>......>>>>>.>.........<<....>>...<<<<......<
<.....>>.....>>>>...(((....<<<<<<<<....>>>>>>>>...
...<<<<<<<<<.....<<<<.......<<<<<<<<<<.<<<.....<<<
<......>>>>.((......<<<.....))>>>...>>>...>>>>>>>>
>>>>>>.>>>>>..>>>>.....<<<<<<<<.........>>>>>>>>..
....<<<<<..<<<<>>>>>..)))......]].>>>>>>>.]]......
.........<<....>>....]].........<<<<....>>>>......
.......}....>>>>>>>>>>>.......<<<<..<<<<......>>>>
..>>>>...<.<........>.>.<<<<<<....<<<<<<<.<<<<<..<
<<...<<<.....>>>...>>>...<<....>>..<<<<.....>>>>..
....>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<
<....<<<<<<......>>>>>>.....>>>...<<<.<<<<<.......
.>>>>>>>>....>>>>>>>>>...<<<.....>>>......>>>>>>..
.>..>.>>..<<<<<<....<<<<<....>>>>><<<<<<<<<...<<<<
<<<<<.....<<<...<<<<<<<<......<<<<.....>>>>.......
>>>>>>>>..>>.>.....>>>>.>>>>>..>>>>>>>.>>..<<<<<<<
.<<......>>.>>>>>>>....<<<......>>>...<<<<.<<<...<
<<(((.....<<<<<<...........<<..<<<<<<<<<........<<
<<<.<<.....................>>.........<<......>>..
.>>>>>....>>>>>>>>>.>>...........))).....>>>>>>.>>
>...>>>>>>><<<<<<<...>>>>>>>....>>>>>><.<<<<<<<.<<
......<<<<<.<<....>>.>>>>>...>>.>>>>>>>..>.....>>>
>>><......<<....<<<<<<.......>>>>>><<<<....<<<<<.<
<<..<<<<<<...<<.....>>.>>>>>>....((<<<<.<<...<<<..
.<<<....>>>...>>>...>>...<<<<<........>>>>>))<<<<<
.<<<<<<......<<...<<<<....<<<<..<<<..<<<.<.<<<.<..
...{....>.>>>.<<..<......<<.<.<<<<<<<.<<.....>>>>>
>>>>.....>>>......>...>><..<<...........>>...>>.>>
>...>>>...>>>>.........>>>>..>>..>>>>>>>>>>>>>>>.>
>>.....<<......>>>>>>>.<<<<.....>>>>..>>>>..<<<<..
..<<<<<<<<.<<<........<.....<<<<<....<<..>>.....>>
>>><<<<<....<<<<....>>>>...>>>>>............<<<<<<
<<<..<<<.........>>>..<<<<<<<.....<<<....>>>......
.>>>>>>>..<<<<.<<<..<<<<<<<..<<<...<<...<<<<<..<<.
...>>...>>>>>...>>...>>>>>>>>..>>>>><<<<<<.......>
>>>>>........<...........<<<<<.......>>>>>.....>..
..>>>>...>>.>>>>>>>..>.>>>.>>>>>>>>.>>>>>>.....>..
...<<<<<........>>>>>..<<<<<<<<.(((.[[......<<<<.[
[<<<<..<<<<<.<<<<<<<<<.<<<.<<<..<<<<<<............
<<<<<..<<...............................>>........
....>>>>>..>.>>>>>..>>>.>>>....<<.<<<<<.......>>>>
>>>.....>>>>>>>>>..>>>>>..<<<<.....>>>><<<<<<.....
......>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>..
...<<.[.(((>>....>>>>>>>...<<<<..<<<......>>>..>>>
>.<<<....>>>.>>)))]......<<<<<<<.((..>>>>..))>>>>>
>>.............>>>>..]]>>>>.......<<<<...<<<<<<...
<<.......>>...>>>>>>....>>>.>.......<<<<<.<<<<<<..
<<<<<<<<<......>>>>>>..>>>.<<<<<.....>>>>>.....>>>
>>..>...>>>.>>....<<<<<<<....>>>.>>>>....]]..)))>>
>>>>>>....<<<<<<<...<<<<..<<<<<<<...............>>
>>>>>.<<<<<...<<<<...<<<<<<<<<<<.}..>>>>>>..>>>>>.
..>>>>.>>>>>...<<<....<<<<<...........>>>>>....>>>
.>>>>.......>>>>>>>..<<<<....>>>>....<<<<<<<<<....
...>>>>>....<<<<<<<<.<<<....<<<<<....>>>>>...>>>..
>>>>>.>>>...>>>>....>>>>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6tnn Structures of B. subtilis Maturation RNases Captured on 50S Ribosome with Pre-rRNAs.
• Resolution: 3.07 Å
• Binding residue (original residue number in PDB): S2 Y3 K5 G7 S10 R13 R18 D23 N27 T32 T35 R36 K38 E45 H57 R59 R60 Q61 R67 R94 Q95 G96 G97 T99 R100 R107 R108 G109 D110
• Binding residue (residue number reindexed from 1): S1 Y2 K4 G6 S9 R12 R17 D22 N26 T31 T34 R35 K37 E44 H56 R58 R59 Q60 R66 R93 Q94 G95 G96 T98 R99 R106 R107 G108 D109

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6tnn, PDBe:6tnn, PDBj:6tnn
• PDBsum: 6tnn
• PubMed: 32991829
• UniProt: P20277|RL17_BACSU Large ribosomal subunit protein bL17 (Gene Name=rplQ)