Structure of PDB 5xyi Chain g Binding Site BS01

Receptor Information
>5xyi Chain g (length=305) Species: 5722 (Trichomonas vaginalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AHFAPRATFVGHNAAIESIEIDNEHNYLVSASRDKSALVWKLNRTQEQWA
TPFTRLIGHNHFVSDVSLSRDASHLLTSSWDSTLRLWDLSTRTTKKLFLG
HKKDVLGVTFSPCNRRIISVGRDNQVKIWNILGENKAELQCSSWVTSVAC
APMADETSPLVIAVGCWDGKVYIWSIEKEAKLIKEFKAHDGRCTSVDFTP
DGKWVITGSDRKVVMWLTENGAKTISFTAPSPVHAVAACPTQAWICAATY
EGIAVWDIGAKQQIDLVQPNFNAGRTPDCTCLAWAADGSVLYSGYNDGSI
RAWEV
Ligand information
>5xyi Chain 2 (length=1490) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
acuugguugauccugccaaggaagcacacuuaggucauagauuaagccau
gcaaguguuaguaacugcgaauagcucauuaauacgcucagaaucuauuu
ggcggggauagcagcagcaacucuggugcuaauacaugcuguuucuccag
augugaauuauggaggaaaaguugaccucgaggcacgccauucgacugag
ugaccuaucagcuuguacuuagggucuuuaccuagguaggcuaucacggg
uaacgggcgguuaccgucggacugccggagaaggcgccugagagauagcg
acuauauccacggguagcagcaggcgcgaaacuuucccacucgagacuuu
cggaggagguaaugaccaguuccauugguuacguggauagggguacgguu
uuccaccguaccgacuagcagagggcagucuggugccagcagcugcggua
auuccagcucugcgaguuugcucccauauuguugcaguuaaaacgcccgu
agucugaauuggccagcaauggucguacguauacguucacugugaacaau
caggacgcuuagaguauggccacaugaaugacucagcgcaguaugaaguc
uuuguuaaaacaagcucaaugagagccaucggggguagaucuaucucaug
acgagugguggaauacuuugacucaugagagagaagcugaggcgaaggcg
ucuaccuagaggguuucugucgaucaagggcgagaguaggaguauccaac
aggauuagagacccugguaguuccuaccuuaaacgaugccgacaggaguu
ugucauuuguuaauggcagaaucuuuggagaaaucauaguucuugggcuc
ugggggaaauacgaccgcaaggcugaaacuugaaggaauugacggaaggg
cacaccagggguggagccuguggcuuaauuugaaucaacacggggaaacu
acccaggaccagauguuuaugacugacaggcuucgggucuuucaggauau
uguuuuugguggugcauggccguugguggugcguggguugaccuguccgu
ugauucagcuaacgagcgagauuaucgccaauuauuuacuuugccgaagu
ccuucgguuaaaguucuaauugggacucccugcguagcagguggaagagg
guagcaauaacagguccgugaugcccuuuagaugcucugggcugcacgcg
ugcuacaauguuaggacaauaggagcgagccugagagggugcgcuacucu
uauaaucccuaacguaguugggauugacguuuguaaucagcgucaugaac
caggaaucccuuguaaaugugugucaacaacgcacguugaauacgucccu
gcccuuuguacacaccgcccgucgcuccuaccgauuggaugacucgguga
aaucaccggauggaaagugauuaaaucacguuaucuagaggaaggagaag
ucguaacaagguaacgguaggugaaccugccguuggauca
..<<<<<.[.((((>>>>><<.<<<<.<<...<<<<<<<......<<<.<
<<..<<....<<.>>.>>......<<........<<<<<<...<<....<
<<<<..<...<<<.<<.......>>.>>>.....>......<<<<<<<<.
..<.....>.>>>>>>>>.......<<<..>>>..>>>>>...>>.>>>>
>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>>>......>>>
...<<<.<<<<....>>>>.....>>>.>>.<<.<<<..........>>>
.>>.<<<<....>>>>...>>>>>>.........<<<....<<<<...>>
>>..>>>..>>.>>>>>...<<<<.<<....>>>>>>....<<<<<<<<.
....>>>>>>>>.....<<<<<((...<.<<<<.....<<..))>>....
...>>>>>>>>>>..>>.>>>>.>>.........<<<((.....<<<<..
.<<<.<<...<<<<......>>>>....<<..>>.<<<<<<<<<.....<
<<..<<.......>><<<....>>>...>>>.....>>>>>..>>>>...
...<<....>>....>>....<<<<<<.<...<<<<<<<<<..<<<<<<<
<...<<<......>>>......>>>>>>>>..>>.......<<....>>.
>>>>>>>...>>>>.>>>...>>>...>>>>..<.<<<<<<<...<...<
<<<.<.....>.>>>>...>>>>>>>>..>.......<<<.<<.<<<.<<
<<<<<<<....>>>>>>>>>.>>>...<<..))>>...>>.....>>>.>
>>.<<<......<.<<....>>.>....>>>..)))).]<<<<<.<<<<<
<<.<<..<<<<<..<<<.<<<<<<......<<........>>........
.<<<<<<...............<<<<.<<<.......>>>.>>>>.....
.......<<.<<<..<<.<<<<<<....<<.<<<<<<....>>>..<.<.
.....>.>...>>>.>>....<<<<<.<<<<<<<...<<<<<<<<<<<..
..>>>>>>.>>>>>..>>>>>>>.....<<<<<...>>>>>........>
>>>>....>>>.>>>.....>>>>>>>........>>>>>>..>>.>>>>
.>>>.....<<<<<<.....<<<.<<..<<<<....>>>>..>>....>>
>......>>>>>>...........<<<<<<<.......>>>>>>>.....
.....>>>>>.....<<<<<<<<.......>>>>>>>>......>>...>
>>>>>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<..<<<..
<<<<<<..........>>>>>>..>>>..>>>>>>>...>>.>>>>>..>
.>>...>.....<<<<<<<<<....>>>>>>>>>......
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xyi Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii
Resolution3.35 Å
Binding residue
(original residue number in PDB)		N80 H81 R105 G301 R302
Binding residue
(residue number reindexed from 1)		N60 H61 R85 G274 R275
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005080 protein kinase C binding
GO:0043022 ribosome binding
GO:0045182 translation regulator activity
Biological Process
GO:0006417 regulation of translation
GO:0035735 intraciliary transport involved in cilium assembly
GO:0072344 rescue of stalled ribosome
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0036064 ciliary basal body
GO:0097542 ciliary tip
GO:0097729 9+2 motile cilium
GO:1990900 ciliary pocket collar

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5xyi, PDBe:5xyi, PDBj:5xyi
PDBsum5xyi
PubMed28809395
UniProtA2ELV7

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