Structure of PDB 4v7f Chain g Binding Site BS01

Receptor Information

>4v7f Chain g (length=99) Species: 4932 (Saccharomyces cerevisiae)

TVKTGIAIGLNKGKKVTSMTPAPKISYKKGAASNRTKFVRSLVREIAGLS
PYERRLIDLIRNSGEKRARKVAKKRLGSFTRAKAKVEEMNNIIAASRRH

Ligand information

>4v7f Chain 1 (length=3394)

uugaccucaaaucagguaggaguacccgcugaacuuaagcauaucaauaa
gcggaggaaaagaaaccaaccgggauugccuuaguaacggcgagugaagc
ggcaaaagcucaaauuugaaaucugguaccuucggugcccgaguuguaau
uuggagagggcaacuuuggggccguuccuugucuauguuccuuggaacag
gacgucauagagggugagaaucccguguggcgaggagugcgguucuuugu
aaagugccuucgaagagucgaguuguuugggaaugcagcucuaagugggu
gguaaauuccaucuaaagcuaaauauuggcgagagaccgauagcgaacaa
guacagugauggaaagaugaaaagaacuuugaaaagagagugaaaaagua
cgugaaauuguugaaagggaagggcauuugaucagacaugguguuuugug
cccucugcuccuuguggguaggggaaucucgcauuucacugggccagcau
caguuuugguggcaggauaaauccauaggaauguagcuugccucgguaag
uauuauagccugugggaauacugccagcugggacugaggacugcgacgua
agucaaggaugcuggcauaaugguuauaugccgcccgucuugaaacacgg
accaaggagucuaacgucuaugcgaguguuuggguguaaaacccauacgc
guaaugaaagugaacguagguuggggccucgcaagaggugcacaaucgac
cgauccugaugucuucggauggauuugaguaagagcauagcuguugggac
ccgaaagauggugaacuaugccugaauagggugaagccagaggaaacucu
gguggaggcucguagcgguucugacgugcaaaucgaucgucgaauuuggg
uauaggggcgaaagacuaaucgaaccaucuaguagcugguuccugccgaa
guuucccucaggauagcagaagcucguaucaguuuuaugagguaaagcga
augauuagagguuccggggucgaaaugaccuugaccuauucucaaacuuu
aaauauguaagaaguccuuguuacuuaauugaacguggacauuugaauga
agagcuuuuagugggccauuuuugguaagcagaacuggcgaugcgggaug
aaccgaacguagaguuaaggugccggaauacacgcucaucagacaccaca
aaagguguuaguucaucuagacagccggacgguggccauggaagucggaa
uccgcuaaggaguguguaacaacucaccggccgaaugaacuagcccugaa
aauggauggcgcucaagcguguuaccuauacucuaccgucaggguugaua
ugaugcccugacgaguaggcaggcguggaggucagugacgaagccuagac
cguaaggucgggucgaacggccucuagugcagaucuuggugguaguagca
aauauucaaaugagaacuuugaagacugaaguggggaaagguuccacguc
aacagcaguuggacguggguuagucgauccuaagagauggggaagcuccg
uuucaaaggccugauuuuaugcaggccaccaucgaaagggaauccgguua
agauuccggaaccuggauauggauucuucacgguaacguaacugaaugug
gagacgucggcgcgagcccugggaggaguuaucuuuucuucuuaacagcu
uaucaccccggaauugguuuauccggagauggggucuuauggcuggaaga
ggccagcaccuuugcuggcuccggugcgcuugugacggcccgugaaaauc
cacaggaaggaauaguuuucaugccaggucguacugauaaccgcagcagg
ucuccaaggugaacagccucuaguugauagaauaauguagauaagggaag
ucggcaaaauagauccguaacuucgggauaaggauuggcucuaagggucg
gguagugagggccuuggucagacgcagcgggcgugcuuguggacugcuug
guggggcuugcucugcuaggcggacuacuugcgugccuuguuguagacgg
ccuugguaggucucuuguagaccgucgcuugcuacaauuaacgaucaacu
uagaacugguacggacaaggggaaucugacugucuaauuaaaacauagca
uugcgauggucagaaagugauguugacgcaaugugauuucugcccagugc
ucugaaugucaaagugaagaaauucaaccaagcgcggguaaacggcggga
guaacuaugacucucuuaagguagccaaaugccucgucaucuaauuagug
acgcgcaugaauggauuaacgagauucccacugucccuaucuacuaucua
gcgaaaccacagccaagggaacgggcuuggcagaaucagcggggaaagaa
gacccuguugagcuugacucuaguuugacauugugaagagacauagaggg
uguagaauaagugggagcuucggcgccagugaaauaccacuaccuuuaua
guuucuuuacuuauucaaugaagcggagcuggaauucauuuuccacguuc
uagcauucaaggucccauucggggcugauccggguugaagacauugucag
guggggaguuuggcuggggcggcacaucuguuaaacgauaacgcagaugu
ccuaaggggggcucauggagaacagaaaucuccaguagaacaaaagggua
aaagcccccuugauuuugauuuucagugugaauacaaaccaugaaagugu
ggccuaucgauccuuuagucccucggaauuugaggcuagaggugccagaa
aaguuaccacagggauaacuggcuuguggcagucaagcguucauagcgac
auugcuuuuugauucuucgaugucggcucuuccuaucauaccgaagcaga
auucgguaagcguuggauuguucacccacuaauagggaacgugagcuggg
uuuagaccgucgugagacagguuaguuuuacccuacugaugaauguuacc
gcaauaguaauugaacuuaguacgagaggaacaguucauucggauaauug
guuuuugcggcugucugaucaggcauugccgcgaagcuaccauccgcugg
auuauggcugaacgccucuaagucagaauccaugcuagaacgcggugauu
ucuuugcuccacacaauauagauggauacgaauaaggcguccuuguggcg
ucgcugaaccauagcaggcuagcaacggugcacuuggcggaaaggccuug
ggugcuugcuggcgaauugcaaugucauuuugcguggggauaaaucauuu
guauacgacuuagauguacaacgggguauuguaagcaguagaguagccuu
guuguuacgaucugcugagauuaagccuuuguugucugauuugu

........................<<<<<<<....<.....<>.>....>
>>>>.>...{.....<<....>>..<<<<<.<....<<...>.>>>....
>>>>>..[[[..<<<......<<.<<<<<<...>>>>>>.>>......>>
>....<<<<<<<.<<<<<<<<<<<<<<<<<<<<.....<<<<......>>
>>.(.......<<<......)>>>....>>>>>>>>..>>>>>>>>....
>>>>>>>>>>>........<<<<<<<........>>>>>>>.....((((
(..<<<<<<)))))..]]]....}..........................
...<<....>>...............<<<<....>>>>............
......................<<<<<.<<<<<.....<<<<<...<<<.
.<<<<<<.<<<....>>>>>>>>>......>>>...>>>>>.<<<<<<<.
<<<<<<<<<<<<<<<.....<<<<<<<<<......<<<<<<....>>>>>
>.......>>>>>>>.>.>.>>>>>.>>>>>>>>>>........<<<...
.>>>.....>>>>>>>.....>>>>>.>>>>>..<<.<.<....>.>.>>
<<<<<<...<.<<<<<.<<<<<<..<<<<.<<<<<.....>>>>>.>>>>
...<<....>>.......<<<<<..<<<<<....>>>>>...>>>>>.<<
<<<<<<...<<....>>...>>>.>>>.>>....>>>>>>.>>>>>>..<
<.<..<<<<<<<.....<<<<<<<<<..<<<....<<<<<<<....>>>>
>>>.....>>>...<<<<.<<.<<........>>>>>>>>....>>>>>>
>>>...<<.......>>......>>>>>>...>..>.>>..<<<<<<...
...<<<....>>><.<<<<<<<<<<...<<<.<<<<<<..<.<.<<<...
.<<<....<<<<<..<<<<<<.....>>>>>>>>>>>....>>>..>.>>
>..>..>>>>...<<<<.<<<<.<......>>>>>.>>>>.....>>>>>
.>>>>>>>>.>>>.<<<<.<<<<<.....>>>>>.>>>>....<<<....
..>>>...<<<<<<<..<<<<(((.....<<<<<<<....<<........
..<<<.<<<<<<<<<......<.<<<<<.<<....<<.........>>..
..>>.........<<......>>...>>>>>.>..>>>>>>>>>>>>...
.......))).>>..>>>>>>>.>>>>..>>>>>>><<<<<<<<<.....
....>>>>>>>>>....>>>>>>..(<<<<<<..<.......<<<<.<<<
<....>>>>>>>>...)>.>>>>>>.........>>>>>><<.....<<.
....<<<<<<.......>>>>>><<<<<...<<<<<<.<<...<<<<<<.
..<<.....>>.>>>>>>....((<<<<<<...<<....<<<....>>>.
.......<<<<<<........>>>>>>....>>....>>...<<<<<...
.....>>>>>))<<<<.<<<<<<<...<.<<<....>>>.......<<<<
<<...<<<<.<<<<<<<.<<<<<<<<<<..{{{..>>>>>><...<<<<<
....<<<<<<....<<<.....>>>....>>>>>>.....>>>>>....>
<<<<<<<......>>>>>>>>>>>...>>>>>>>.>>>>.........>>
>>>>....>.....>>>..>>>>>>>>>>>>..>>.....<<......>>
>>>>>><<<<.....>>>>.>>>>>..<<<<.....<<<<<<<.<<....
....<<.....<<<<<...............>>>>><<.<<<<<<<<<<<
.<<<<<<<<.<<...<<<<....<<<<<<<<<<<<<..<<<...<<<<<<
<<<<<<....>>>>>>>>>>>>...>>>..>>>>>>>.>>>>>>....>>
>>...>>.<<<<<.....>>>>>....>>>>>>>>......>>>>>..>>
>>>>.>>............<<<<<<<<<..<<...........>>..<<<
<<<<....<<<<.....>>>>......>>>>>>>.......<<<..<<<<
<.<<..<<<....<<<<<....>>>>.>...>>>>>>>>..>>>>>.<<<
<<.......>>>>>...........<<.<<<<...<<<<<.......>>>
>>..>>>>...>>......>>.>>>>>>>..>>.>>.>>>>>>>..>>>>
>>....>>....<<<<<........>>>>>....[[[[[..[[[.{{...
......{....[[[..<<<<<.<<<<<<<<..<<<<<<<<<<<<<<<<<.
.........<<<<<......................>>>>>.>>>>>>>.
>>>>>>>>>>...<<<<<.....<<<<..<<<<<......>>>>>.....
..........<<<<<<....>>>>>>..>>>>..>>>>>.....>>>>>>
>>..>>>>>..............<<<<<<<<...........>>>>>>>>
.....<<<<<<<...<<<<<<.......>>>>>>.....<<......>>.
...>>>>>>>...<<<.<<<<<.......>>>>.>>>>.<<<....>>>.
............((((((..((((.>>>>>>)))))))))).........
.]]].....}.................<<<<<<<..<<.......>>>..
>>>>>>..................<<<.<<<<<<..<.<<<<<<<.....
.>>>>>>>...>.<<<.<.....>.>>>.....>>>>>..>...>>>...
....<<<<<<<....>>>.>>>>....}}..]]].]]]]]....<<<<<<
<<..<<<<...<<<<<<...............>>>>>>..<<<<<...<<
<<<..<<<<<<<<<<.}}}..>>>>..>>>>>>.>>>>>..>>>>>.<<<
<<..<<<<<...........>>>>>..>>>>>.>>>>....>>>>>>>>.
......<<<<<<.<<<.<<....<<..........<<<<<<.....>>>>
>>......>>.......<<<<<<...<<<<<.<..<<<......>>>..>
.>>>>>.>>>>>>.............>>.>>>.>>>>>>..<<<<<.<..
<<.....>>..>.....<<<<<<<<<.<<<....<<<<.<..<<<<....
....>>>>..>>>>>...>>>....>>>.>>>>>>..>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4v7f 60S ribosome biogenesis requires rotation of the 5S ribonucleoprotein particle.
• Resolution: 8.7 Å
• Binding residue (original residue number in PDB): R98 R99
• Binding residue (residue number reindexed from 1): R97 R98

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003735 structural constituent of ribosome

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:4v7f, PDBe:4v7f, PDBj:4v7f
• PDBsum: 4v7f
• PubMed: 24662372
• UniProt: P05745|RL36A_YEAST Large ribosomal subunit protein eL36A (Gene Name=RPL36A)