Structure of PDB 7ls2 Chain f2 Binding Site BS01

Receptor Information
>7ls2 Chain f2 (length=50) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSHKTFRIKRFLAKKQKQNRPIPQWIRMKTGNKIRYNSKRRHWRRTKLGL
Ligand information
>7ls2 Chain A2 (length=3706) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cgcgaccucagaucagacguggcgacccgcugaauuuaagcauauuaguc
agcggaggaaaagaaacuaaccaggauucccucaguaacggcgagugaac
agggaagagcccagcgccgaauccccgccgcgcgucgcggcgugggaaau
guggcguacggaagacccacuccccggcgccgcucguggggggcccaagu
ccuucugaucgaggcccagcccguggacggugugaggccgguagcggccc
ccggcgcgccgggcucgggucuucccggagucggguugcuugggaaugca
gcccaaagcgggugguaaacuccaucuaaggcuaaauaccggcacgagac
cgauagucaacaaguaccguaagggaaaguugaaaagaacuuugaagaga
gaguucaagagggcgugaaaccguuaagagguaaacgggugggguccgcg
caguccgcccggaggauucaacccggcggcguccggccgugccggugguc
cggcggaucuuucccgcgcgggggaccgcccccggccggcgaccggccgc
cgccgggcgcacuuccaccguggcggugcgccgcgaccggcuccgggacg
gccgggaaggcccgguggggaagguggcucggggggggcucaccccgagu
guuacagcccuccggccgcgcuuuucgccgaaucccggggccgaggaaga
ccgucgccgcgcucucccucucccgggugggggccgggccgccccuccca
cggcgcgaccgcuccggggcggacuguccccagugcgccccgggcgucgu
cgcgccgucgggucccgggggcgucggucacgcgugacgaagccgagcgc
acggggucggcggcgaugucggcuacccacccgacccgucuugaaacacg
gaccaaggagucuaacgcgugcgcgagucaggggcucguccgaaagccgc
cguggcgcaaugaaggugaagggccccgcccgggggcccgaggugggauc
ccgaggccucuccaguccgccgagggcgcaccaccggcccgucucgcccg
ccgcgccggggagguggagcacgagcguacgcguuaggacccgaaagaug
gugaacuaugcuugggcagggcgaagccagaggaaacucugguggagguc
cguagcgguccugacgugcaaaucggucguccgaccuggguauaggggcg
aaagacuaaucgaaccaucuaguagcugguucccuccgaaguuucccuca
ggauagcuggcgcucucgcuacgcaguuuuauccgguaaagcgaaugauu
agaggucuuggggccgaaacgaucucaaccuauucucaaacuuuaaaugg
guaagaagcccggcucgcuggcguggagccgggcguggaaugcgagugcc
uagugggccacuuuugguaagcagaacuggcgcugcgggaugaaccgaac
gccggguuaaggcgcccgaugccgacgcucaucagaccccagaaaaggug
uugguugauauagacagcaggacgguggccauggaagucggaauccgcua
aggaguguguaacaacucaccugccgaaucaacuagcccugaaaauggau
ggcgcuggagcgucgggcccauacccggccgucgccggcagucggaacgg
aacgggacgggagcggcgucgggccccgcggagccuacgccgcgacgagu
aggagggccgcugcggugagccuugaagccuagggcgcgggcccgggugg
agccgccgcaggugcagaucuuggugguaguagcaaauauucaaacgaga
acuuugaaggccgaaguggagaaggguuccaugugaacagcaguugaaca
ugggucagucgguccugagagaugggcgagugccguuccgaagggacggg
cgauggccuccguugcccucggccgaucgaaagggagucggguucagauc
cccgaauccggaguggcggagaugggcgccgcgaggcguccagugcggua
acgcgaccgaucccggagaagccggcgggagccucggggagaguucucuu
uucuuugugaagggcagggcgcccuggaauggguucgccccgagagaggg
gcccgugccuuggaaagcgucgcgguuccggcggcguccggugagcucuc
gcuggcccuugaaaauccgggggagaggguguaaaucucgcgccgggccg
uacccauauccgcagcaggucuccaaggugaacagccucuggcauguugg
aacaauguagguaagggaagucggcaagccggauccguaacuucgggaua
aggauuggcucuaagggcugggucggucgcggccggcgccuagcagccga
cuuagaacuggugcggaccaggggaauccgacuguuuaauuaaaacaaag
caucgcgaaggcccgcggcggguguugacgcgaugugauuucugcccagu
gcucugaaugucaaagugaagaaauucaaugaagcgcggguaaacggcgg
gaguaacuaugacucucuuaagguagccaaaugccucgucaucuaauuag
ugacgcgcaugaauggaugaacgagauucccacugucccuaccuacuauc
cagcgaaaccacagccaagggaacgggcuuggcggaaucagcggggaaag
aagacccuguugagcuugacucuagucuggcacggugaagagacaugaga
gguguagaauaagugggaggcccggccgccggugaaauaccacuacucuc
aucguuuuuucacugacccggugaggcgggggggcgagccccgaggggcu
cucgcuucuggcgccaagcguccgucccgcgcgugcgggcgggcgcgacc
cgcuccggggacagugccagguggggaguuugacuggggcgguacaccug
ucaaacgguaacgcagguguccuaaggcgagcucagggaggacagaaacc
ucccguggagcagaagggcaaaagcucgcuugaucuugauuuucaguacg
aauacagaccgugaaagcggggccucacgauccuucugaccuuuuggguu
uuaagcaggaggugucagaaaaguuaccacagggauaacuggcuuguggc
ggccaagcguucauagcgacgucgcuuuuugauccuucgaugucggcucu
uccuaucauugugaagcagaauucaccaagcguuggauuguucacccacu
aauagggaacgugagcuggguuuagaccgucgugagacagguuaguuuua
cccuacugaugauguguuguugccaugguaauccugcucaguacgagagg
aaccgcagguucagacauuugguguaugugcuuggcugaggagccaaugg
ggcgaagcuaccaucugugggauuaugacugaacgccucuaagucagaau
cccgcccaggcggaacgauacggcagcgccgaggagccucgguuggcccc
ggauagccggguccccguccguccccgcucccgggcgucgggaccggggu
ccggugcggagagccguucgucuugggaaacggggugcggccggaaaggg
ggccgcccucucgcccgucacguugacgcacguucguguggaaccuggcg
cuaaaccauucguagacgaccugcuucugggucgggguuucguacguagc
agagcagcucccucgcugcgaucuauugaaagucagcccucgacacaagg
guuugu
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..>>>>...<<<<<<<<<....<<<<<<<<.<......<<<<<<<<....
<<<<......>>>>.....((......<<<.....))>>>...>.>>>>>
>>..>>>>>>>>>...>>>>>>>>>.......<<<<<<<........>>>
>>>>.....(((((..<<<<<<)))))..]]]..................
................<<....>>...............<<<......>>
>..................................<<<<<<<<..<<<.<
<...<<<<<<<<..<<.....<<<<<<<<<<.<<<.<<<.<<<<<.<...
..<<<<.<<<..<<<<<>>>>>>>>>>>>.>>>>>>>>>....>>>.>>>
>>>>>>>......>.>.>>>.>>>>>...<<<<<<<.<<<<<<<<<<<<<
<<...<<.<<<<.<<..<<<......<<<<<<<<.<....>.>>>>>>>>
........>>>>>>>>>.......>>>>>>..>>>>>>>>>>>.......
........<<<<<<.<<<<..<<..>>..>>>>...<<<.<<<.<.<<<<
<<<<<<<<<<<<<..<<<<<<..............>>>>>>.>>>>..>>
>>>>>>>>.>>>....>>>..>>>>.....<<.....>>.....>>>>>>
......>>.>>>>>...>>>>>...>>>>>>>>..<<<<........>>>
><<<<<<....<<<<<<<<<<<<<..<<<...<<<<........>>>>..
...>>>...<<....>>...<<<<<<<.....>>>>>>>..<<<<<...<
<<..<<<...(((.[...>>>..>>>....>>>>>.<<<<<<<<<.<<<<
......>>>>>>>>>>>.>>....>>>>>>>>>>>>>..<<.<..<<<<<
<<.....<<<<<<<<<..<<<<...<<<<<<<....>>>>>>>...>.>>
>...<<<..<<.<<........>>>>.>>>....>>>>>>>>>...<<..
.....>>......>>>>>>...>..>.>>..<<<<<<....<.<<<....
>>>.><<<<<<<<<<.......<<<.<<<<<<<<<...<<<....<<<..
<.<<<<...<<<<.<<...>>.>>>>.>>>>.>..>>>...>>>...>>>
>>>>...<<<<<<<<<.<......>>>>>>>>>>....>>>>>>>>>>>>
.>>>..<<<<.<<<<<.....>>>>>.>>>>....<<<......>>>...
<<<<<<<...<<<(((.......<<<<<.....<<..........<<<.<
<<<<<<<<<.......<<<<<.<<<...<<.........>>...>>>...
......<<......>>...>>>>>...>>>>>>>>>>>>>..........
))).>>...>>>>>..>>>...>>>>>>><<<<<<.<<<...........
..].)))...<<.<<.>>>>..................>>>>>>>>>...
.>>>>>>...<<<<<<<..<<......<<<<.<<<<....>>>>>>>>..
.>>.>>>>>>>........>>>>>><<.....<<.....<<<<<<.....
..>>>>>>.<<<.....<<<<<.<<...<<<<<<...<<.....>>.>>>
>>>....((<<<<<<...<<....<<<....>>>..........<<.<<<
<<<<<<...>>>>>>>>>>>......>>....>>>..<<<<<........
>>>>>))<<<<....<<<<<...<<<<<<<....>>>>>>>...<<<...
.>>>...<..<<<<<<<...<<<<<<<<<<<<<.<<<<<<<<<..{{{..
>>>>>>....<<<<<.<<<<.<<<......<<<.....>>>......>>>
>>>>..>>>>>.....<<<<<<<<<..>>.>>>>>>>>>>..>.>>>>>>
>>>>>>.........>>>>>>>..>..........>>.>>>.>>>>.>>>
..>>.....<<......>>>>>>>.<<<<.....>>>>..>>>....<<<
<.....<<<<<<<.<<.........<.....<<<<<....<<..>>....
.>>>>><<.<<<<<<<<<<<..<<<.<<..>>.>>>.......>>>>>..
>>>>>>.>>............<<<<<<<<<..<<<.........>>>..<
<<<<<<....<<<<.....>>>>......>>>>>>>...<<..<<<..<<
<<<.<<..<<<.....<<<<....>>>>.....>>>>>>>>..>>>>><<
<<<<.......>>>>>>........<...........<<<<<.......>
>>>>.....>.....>>....>>.>>>>>>>..>..>>.>>>>>>>..>>
>>>>....>>....<<<<<........>>>>>....[[[[[..{{{.{{.
.....[[[[.{{[[[[..<<<<<..<<<<<<<<.<<<<<<<<<<<<<<<<
<...........<<<<..<<<<.>>>>............>>>>..>>>>>
>>.>>>>>>>>>>...<<<<<.....<<<.<..<.<<<<.<<...>>>>>
>.>..............<<<<<<<.<<<<<....>>>>>>>>>>>>..>>
>>..>>>>>....>>>>>>>>...>>>>>...<<<.....>>>..<<<<<
<...........>>>>>>..<<.....<<<<<...<<<<<<.......>>
>>>>.....<<...(((>>....>>>>>.....<<<.<<<<<.......>
>>>.>>>>.<<<....>>>.>>))).......((((((..(((..>>>>>
>.)))))))))..........]]]]..}}]]]].......<<.<.<.<<<
<<<...<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<
<<<<..<.<.<<<<<......>>>>>...>.>.<<<.........>>>..
...>>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....}}.
.}}}.]]]]].....<<<<<<....<<<..<.<<<<<.............
....>>>>>.><<<<....<<<<....<<.<<<<<<<}}}.>>>>>..>>
.>>...>>>>...>>>><<<<<...<<<<<...........>>>>>...>
>>>>.>>>.....>>>>>>.....<<<<<<.<<<..<<.<....<<<...
.....<<<<<<.<<<<<..<..<.<.........>.>....>..>>>>>>
>>>>>.......>>>...<<<..<<<<......<<.<<<<<<........
>>>>>>>>.....>>>>..>>>...............>.>>..>>>>>>>
>><<<<<.<.............>....<<.<<<<<<<.<<.....<<<<.
...<<<<<......>>>>>...>>>>....>>....>>>>.>>>.>>..>
>>>>..
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7ls2 Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance.
Resolution3.1 Å
Binding residue
(original residue number in PDB)
S2 S3 H4 K5 K10 L13 Q17 P22 I35 R36 Y37 N38 R42 H43 W44 R45 K48 L49
Binding residue
(residue number reindexed from 1)
S1 S2 H3 K4 K9 L12 Q16 P21 I34 R35 Y36 N37 R41 H42 W43 R44 K47 L48
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component
External links
PDB RCSB:7ls2, PDBe:7ls2, PDBj:7ls2
PDBsum7ls2
PubMed34815424
UniProtP62892|RL39_MOUSE Large ribosomal subunit protein eL39 (Gene Name=Rpl39)

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