Structure of PDB 8r6c Chain f Binding Site BS01

Receptor Information

>8r6c Chain f (length=177) Species: 679895 (Escherichia coli BW25113) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

AKLHDYYKDEVVKKLMTEFNYNSVMQVPRVEKITLNMGVGEAIADKKLLD
NAAADLAAISGQKPLITKARKSVAGFKIRQGYPIGCKVTLRGERMWEFFE
RLITIAVPRIRDFRGLSAKSFDGRGNYSMGVREQIIFPEIDYDKVDRVRG
LDITITTTAKSDEEGRALLAAFDFPFR

Ligand information

>8r6c Chain Z (length=72) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gccgaaguggcgaaagggacgcaguugauucaaaaucaaccguugccggu
ucgaguccggccuucggcacca

<<<<<<<..<<<.......>>>.<<<<<<.....>>>>>>....<<<<<.
......>>>>>>>>>>>>....

Receptor-Ligand Complex Structure

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PDB	8r6c Paenilamicins from the honey bee pathogen Paenibacillus larvae are context-specific translocation inhibitors of protein synthesis.
Resolution	2.2 Å
Binding residue (original residue number in PDB)	S73 A75 R80
Binding residue (residue number reindexed from 1)	S72 A74 R79

Gene Ontology

	Molecular Function
GO:0000049	tRNA binding
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0008097	5S rRNA binding
GO:0019843	rRNA binding

	Biological Process
GO:0000027	ribosomal large subunit assembly
GO:0002181	cytoplasmic translation
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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External links

PDB	RCSB:8r6c, PDBe:8r6c, PDBj:8r6c
PDBsum	8r6c
PubMed	38826346
UniProt	P62399\|RL5_ECOLI Large ribosomal subunit protein uL5 (Gene Name=rplE)

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