Structure of PDB 8pr2 Chain f Binding Site BS01

Receptor Information
>8pr2 Chain f (length=711) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSGVNRWIREIQKVTKLDRDPASGTALQEISFWLNLERALYRIQEKRESP
EVLLTLDILKHGKRFHATVSFDTDTGLKQALETVNDYNPLMKDFPLNDLL
SATELDKIRQALVAIFTHLRKIRNTKYPIQRALRLVEAISRDLSSQLLKV
LGTRKLMHVAYEEFEKVMVACFEVFQTWDDEYEKLQVLLRDIVKRKREEN
LKMVWRINPAHRKLQARLDQMRKFRRQHEQLRAVIVRVLRPQVFDAADAN
AIEEVNLAYENVKEVDGLDVSKEGTEAWEAAMKRYDERIDRVETRITARL
RDQLGTAKNANEMFRIFSRFNALFVRPHIRGAIREYQTQLIQRVKDDIES
LHDKFKVQYPQSQACKMSHVRDLPPVSGSIIWAKQIDRQLTAYMKRVEDV
LGKGWENHVEGQKLKQDGDSFRMKLNTQEIFDDWARKVQQRNLGVSGRIF
TIESTRVRGRTGNVLKLKVNFLPEIITLSKEVRNLKWLGFRVPLAIVNKA
HQANQLYPFAISLIESVRTYERTCEKVEERNTISLLVAGLKKEVQALIAE
GIALVWESYKLDPYVQRLAETVFNFQEKVDDLLIIEEKIDLEVRSLETCM
YDHKTFSEILNRVQKAVDDLNLHSYSNLPIWVNKLDMEIERILGVRLQAG
LRAWTEMFAWKMVVLSLPRIQSQRYQVGVHYELTEEEKFYRNALTRMPDG
PVALEESYSAV
Ligand information
>8pr2 Chain j (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
VHDKELAAEDEQVFLMKQQSLLAKQ
Receptor-Ligand Complex Structure
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PDB8pr2 Molecular mechanism of dynein-dynactin complex assembly by LIS1
Resolution3.8 Å
Binding residue
(original residue number in PDB)		R716 I720 L733 A806 K809 K810 Q813 A817 I820 N895 I898
Binding residue
(residue number reindexed from 1)		R448 I452 L465 A538 K541 K542 Q545 A549 I552 N627 I630
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008569 minus-end-directed microtubule motor activity
GO:0016887 ATP hydrolysis activity
GO:0045505 dynein intermediate chain binding
GO:0051959 dynein light intermediate chain binding
Biological Process
GO:0007018 microtubule-based movement
GO:0007052 mitotic spindle organization
GO:0007097 nuclear migration
GO:0008090 retrograde axonal transport
GO:0031122 cytoplasmic microtubule organization
GO:0032388 positive regulation of intracellular transport
GO:0033962 P-body assembly
GO:0034063 stress granule assembly
GO:0051293 establishment of spindle localization
GO:0051301 cell division
GO:0060236 regulation of mitotic spindle organization
GO:0090235 regulation of metaphase plate congression
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1905832 positive regulation of spindle assembly
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005868 cytoplasmic dynein complex
GO:0005874 microtubule
GO:0005881 cytoplasmic microtubule
GO:0005938 cell cortex
GO:0016020 membrane
GO:0030175 filopodium
GO:0030286 dynein complex
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome
GO:1904115 axon cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:8pr2, PDBe:8pr2, PDBj:8pr2
PDBsum8pr2
PubMed38547289
UniProtQ14204|DYHC1_HUMAN Cytoplasmic dynein 1 heavy chain 1 (Gene Name=DYNC1H1)

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