Structure of PDB 8fvy Chain f Binding Site BS01

Receptor Information
>8fvy Chain f (length=35) Species: 941442 (Giardia intestinalis assemblage A) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EPKKVRLACLKYYTIKGDTAEPNCGARHADRCHCG
Ligand information
>8fvy Chain 2 (length=1441) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
cauccggucgauccugccggagcgcgacgcucuccccaaggacgaagcca
ugcaugcccgcucaccggacgcggcggacggcucaggacaacgguugcac
cccccgcggcgguccuagccggacaccgcuggcaacccggcgccaagacg
ugcgcgcaagggcgggcgcccgggcgagcagcgugacgcagcgacggccc
gcccgggcuuccggggcaucacccggucggcgcggucgcggcgcgccgag
ggcccgacgccuggcggagaaucaggguucgacuccggagagcgggccug
cgagacggcccgcacauccaaggacggcagcaggcgcggaacuugcccaa
ugcgcggcgcgcgaggcagcgacggggagcgcgcgagcgaggcgggccca
cagcccccgccgcggagccgagggcaagcuggugccagcagccgcgguaa
uuccagcucggcgagcgucgcgcggcgcugcugcaguugaaacgcccgua
guuggccccccgccgccacgaggaaacgggagcgcuccaggcaggcccgu
uggacccgccgcgugggaccgcgcagcgggcgcggcgcgccgcggcagcc
ccgaggagagcgggcgggggcaccgguaccggccggggacgggugaaaca
ggaugaucccgccgagaccgccggccgcgcaggcgccugccaagaccgcc
ucugucaaucaagggcgaaggccgggggcuagaaggcgaucagacaccac
cguauucccggccguaaacggugccgccccgcggccggcgcgcgcguccc
gccggccgcccagggaaaccgggaggcuccgggcucuggggggaguaugg
ccgcaaggcugaaacuugaaggcauugacggagggguaccaccagacgug
gagucugcggcucaaucugacccaacgcgcgcaccucaccaggcccggac
gcgcggaggaccgacagccgggcgcgcuuucgcgaucgcgcgggcggugg
ugcauggccgcucccagcccguggcgcgagccgucugcuccauugcgaca
acgagcgagaccccggccgcgggcgccgcgggacggcccgcgcgagcggg
aggacggcggggcgauagcaggucugugaugcccucagacgcccugggcc
gcacgcgcgcuacacuggcggggccagccggcgcccgcgaggacgcgcgg
agcccccgccguggccgggaccgcgggcuggaacgcccccgcgcaccagg
aaugucuuguaggcgcccgcccccaccgcgcgccggacgcgucccugccc
cuuguacacaccgcccgucgcuccuaccgacugggcgcggcggcgagcgc
cccggacgcgcgaagggccgcgagcccccgcgccuggaggaaggagaagu
cguaacaagguauccguaggugaaccugcggauggaucccu
...<<<<<.{..(((>>>>>.<<<<<<<<<..<<<<<..<......<<<.
<<<..<<.<<<.........>>>>>......<<........<<<..<<..
<<...<<<<..........<<.....<<<<<<....>>>>>>......>>
.....<<....<<<...(((..<.....>..>>>...>>.........>>
>>..>>>>..>>>.<<<....<<<..<<<<<<<<.......>>>>>>>>>
>>......>>>...<<<<<<<<....>>>>...>>>>.>>.<<<<<<...
.......>>>>>>.<.<<....>>.>...>>>>>>.........<<<...
.<<<<...>>>>..>>>..>...>>>>>............<<<<<<....
.....>>>>>>.....<<<<<((....<<<<<.....<<..))>>.....
..>>>>>>>>>>..>>>>>>>>>..........<<<[[.....<<<<...
<<<.......<<<.<<<<<<.<.....<<..<<.......>>........
....>>..>..>>>>>..>.>>>..<<.<<<..)))..>>>...>>....
......<<<<<<<.....<<<<..<<..<<<<<.<<<..<.<......>.
>.....>>>.>>>>.>.>>.......<<....>>...>>>>....>>>>.
>>>...>>>...>>>>...<<<<<<<<...<...<<.<.<.....>.>.>
>...>>>>>>>>>.........<<<.<<..<<<<<<<<<<.<.....>.>
>>>>>>>>>...<<..]]>>....>>.....>>>.>>>.<<<......<<
<<....>>>>....>>>..)))..}<<<<<.<<<<<<<..<<..<<<<<.
.<<<.<<<<<<......<<........>>.........<<<<<.<....<
<<<<<......<<<.<<<.......>>>.>>>....>>>>>>...<<.<<
<..<<.<<<<<<....<<.<<<<<<....>>>....<<......>>....
>>>.>>....<<<<..<<<<<<...>>>>>>.....<<<<<....>>>>>
........>>>>....>>>.>>>.....>>>>>>>.....>.>>>>>...
>>.>>>>.>>>.....<<<<<<<.....<.<<<.<<....>>.>>>..>.
...>>>>>>>......<....<<.<<<<......>>>>.>>....>....
.>>>>>.....<<<<<.<<.......>>.>>>>>......>>...>>>>>
>>>>>.>>....<..<<.<.<<<<<.<<....<<<<<<<<.<<<..<<<.
<<<...........>>>.>>>..>>>.>>>>>>>>...>>.>>>>>..>.
>>...>.....<<<<<<<<<....>>>>>>>>>........
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB8fvy The Giardia lamblia ribosome structure reveals divergence in several biological pathways and the mode of emetine function
Resolution2.94 Å
Binding residue
(original residue number in PDB)		E86 P87 K89 Y98 E106 R123 D126 C128
Binding residue
(residue number reindexed from 1)		E1 P2 K4 Y13 E21 R27 D30 C32
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005840 ribosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8fvy, PDBe:8fvy, PDBj:8fvy
PDBsum8fvy
PubMed38242118
UniProtA8BNY1

[Back to BioLiP]