Structure of PDB 8a3w Chain f Binding Site BS01

Receptor Information
>8a3w Chain f (length=123) Species: 347515 (Leishmania major strain Friedlin) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VKPTVSKAIVKKRTKRFTRHRYELFPQLSSSWRKPRGEDSPVRRRYKGQK
AMPNKGYGSDRATKYITPSGFRNFPINNVEDLYMLVMQNRKYAGVISHTV
GARKRKAIVRKAMELDVRLANGN
Ligand information
>8a3w Chain 1 (length=1467) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
agaccugaguguggcaggacuacccgccgaacuuaagcauauuacucagc
ggaggaaaagaaaacaaccgugauucucucagugagcggcgagcgaagag
ggaacgaacucguugccgaaucgggucuuacaaggccuugaguuguggca
cgugguuggugcaggaguggcgaaauucaagaaagcaaacccguugcuga
auacaaucauggaguauugagccaaagaagguguuagcccauugagccau
aaaccugagcgccucaugaacuaagcgaguagcacuguuugggaaugcag
ugucaaguuggcagguauuugucugccaaaguuaaauacagaguaggaag
accgauagcgaacaaguagcgugagcgaaaguuugaaaagcacuuuggaa
agagagugaaauagaaccugaagucgugacaaagacaauggaaguaccuc
cauuucaacggccagaaccagcccuugcauuauccugugggaaauccggc
ggggugcaaugguguuggcgauggaaauggggugcccccacccgucuuga
aacacggaccaaggagucaaacagacgcgcaagggaggagauaugccagu
acuucucucguacugaaagggagaugcaaugcaucuguggugugcacacg
ucaaauccguuugauuugcccaacaccgaccggcccuccguggguugcgu
uggagugugccuguuuggacccgaaagguggugaacuaugccugaacaag
gugaagcccggggaaacccagguggaggccuguagcgaugcugacgugca
aaucgcucguaugauuuggguaucggagcgaaagacucaucgaaccaccu
aguagcugguucacaucgaaguuucccucaggauagcuggugcuaguaga
aguauugugcgguaaagcacuuuaaaugugcaaacaaaccggccuuagcc
aacugcaaggccggaaagaaaagaauuagaggcaccaagugggccuucuu
cgguaagcggagcaggcgaugcggaaugaaccgcuuagggauauguggcg
ucaaaacuuaugggcucauucucgauacgugaaaaggguguuggugcacc
ggccccgaaaauggaugacgcuuaagcccaauuagugauugcccauuauu
ccuuugguaagggcgagaaaguguagcccuuccgauguagauguggccug
gagguuaggacgaagcuuauggcgugagccuaagauggaccggccucuag
ugcagaucuugguuggcguagcaaagaucuaacggagauauacucaacau
gcaacguuggauacuggagcggggaaggauuucgugccaacggcacucgu
acacgaguuguucggaaacugagcacaacguuauaucguuuuguuaggaa
agugaaggaacugaaaaggggcaacagagaaccugggauuauauuccaaa
aagaaauugcauguggg
......................<<<<<......<......>.......>>
>>.>.........<<....>>..<<<<<<......<<.....>>....>>
>>>>...<<<...<<<<<..<<<<<<<......>>>>>.>>....>>>>>
.<<<...<<<<<<<<.<<<<<......<<<...<<<<.......>>>>..
...<<....>>.....>>>.<<.......((.....>>)).....>>>>>
...>>>..>>>>>.>>>..............<<<<<<<........>>>>
>>>......<<<<<........>>>>>..>>>..................
..................<<....>>................<<<<....
>>>>..................................<<<..<<<<<<.
<<<<<......<<<<.<<<<.....<<<<<...<<<<<<<....>>..>>
>>>>>>>>.>>>>.>>>>......>>>>>>>>>>>..>>>.<<<<.....
...>>>><<<<<<....<<<<<<<.<<<<<..<<<<..<<.<........
>>>..>>>>...<<....>>..<<<<<...>>>>>...<<<<<...<<.<
<<<<<....>>>>>>.>>....>>>>><<<<<<<<<.....>>>>>>.>>
>...>>>>>.>>>>>>>..<<.<..<<<<<<<.....<<<<<<<<<..<<
<....<<<.<<<....>>>.>>>.....>>>...<<<<.<<.<<......
..>>>>>>>>....>>>>>>>>>...<<.......>>......>>>>>>.
..>..>.>>...<<<<<....<.<<<....>>>.><<<<<<<<<.....<
<...<<<<<<....<<<..>>.>....>>>>>>.....<<<<<<<<.<<.
....>>>>>>>>>>...........>>...>>>>>>>.>>..<<<<.<<<
<<.....>>>>>.>>>>...<<<<......>>>>..<<<<<<<...<<<(
((......<..<<<<........<...........<<<<....<..>...
.>>>>...........))).>....>>>>.>.........>>>...>>>>
>>><<<<.<<<<<.............>>>>>>>>>....>>>>>..<.<<
<<<<<<........<<<<..<<<....>>>.>>>.>.....>>>>>>>>.
.>.....>>>>>>..............<<<<<<<................
....>>>>>>>....................<<<<<....<<.....>>.
.>>>>>....<<..........<<.<<<<<......>>>>..........
......<....>......>.>>..........<<<<.........>>...
.>>.>>...........
Receptor-Ligand Complex Structure
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PDB8a3w CRYO-EM STRUCTURE OF LEISHMANIA MAJOR 80S RIBOSOME : WILD TYPE
Resolution2.89 Å
Binding residue
(original residue number in PDB)		K12 K13 R17 P27 Q28 L29 W33 R34 K35 R37 G38 E39 D40 R44 R45 R46 Y47 K48 N55 K56 G57 Y58 G59 S60 D61 R62 K65 Y66 P69 S70 N79 Y84 H99 T100 A103 R104 R106 K112 N122
Binding residue
(residue number reindexed from 1)		K11 K12 R16 P26 Q27 L28 W32 R33 K34 R36 G37 E38 D39 R43 R44 R45 Y46 K47 N54 K55 G56 Y57 G58 S59 D60 R61 K64 Y65 P68 S69 N78 Y83 H98 T99 A102 R103 R105 K111 N121
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
Biological Process
GO:0006412 translation
Cellular Component
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:8a3w, PDBe:8a3w, PDBj:8a3w
PDBsum8a3w
PubMed
UniProtQ4QC11

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