Structure of PDB 7tql Chain f Binding Site BS01

Receptor Information
>7tql Chain f (length=54) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HQQLYWSHPRKFGQGSRSCRVCSNRHGLIRKYGLNMCRQCFRQYAKDIGF
IKLD
Ligand information
>7tql Chain 2 (length=1656) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
uaccugguugauccugccaguagcauaugcuugucucaaagauuaagcca
ugcaugucuaaguacgcacggccgguacagugaaacugcgaauggcucau
uaaaucaguuaugguuccuuuggucgcucguacuuggauaacugugguaa
uucuagagcuaauacaugccgacgggcgcugacccccuucgcggggggga
ugcgugcauuuaucaguggugacucuagauaaccucgggccgaucgcacg
ccggcggcgacgacccauucgaacgucugcccuaucaacuuucgauggua
gucgccgugccuaccauggugaccacgggugacggggaaucaggguucga
uuccggagagggagccugagaaacggcuaccacauccaaggaaggcagca
ggcgcgcaaauuacccacucccgacccggggagguagugacgaaaaauaa
caauacaggacucuuucgaggcccuguaauuggaaugaguccacuuuaaa
uccuuuaacgaggauccauuggagggcaagucuggugccagcagccgcgg
uaauuccagcuccaauagcguauauuaaaguugcugcaguuaaaaagcuc
guaguuggaucucuagcguuuacuuugaaaaaauuagaguguucaaagca
ggccgccuggauaccgcagcuaggaauaauggaauaggaccgcgguucua
uuuuguugguuuucggaacugaggccaugauuaagagggacggccggggg
cauucguauugcgccgcuagaggugaaauucuuggaccggcgcaagacgg
accagagcgaaagcauuugccaagaauguuuucauuaaucaagaacgaaa
gucggagguucgaagacgaucagauaccgucguaguuccgaccauaaacg
augccgaccggcgaugcggcggcguuauucccaugacccgccgggcagcu
uccgggaaaccaaagucuuuggguuccggggggaguaugguugcaaagcu
gaaacuuaaaggaauugacggaagggcaccaccaggaguggagccugcgg
cuuaauuugacucaacacgggaaaccucacccggcccggacacggacagg
auugacagauugauagcucuuucucgauuccgugggugguggugcauggc
cguucuuaguugguggagcgauuugucugguuaauuccgauaacgaacga
gacucuggcaugcuaacuaguuacgcgaccggucggcguaacuucuuaga
gggacaaguggcguucagccacccgagauugagcaauaacaggucuguga
ugcccuuagauguccggggcugcacgcgcgcuacacugacuggcucagcg
uguccuacgccggcaggcgcggguaacccguugaaccccauucgugaugg
ggaucggggauugcaauuauuccccaugaacgaggaauucccaguaagug
cgggucauaagcuugcguugauuaagucccugcccuuuguacacaccgcc
cgucgcuacuaccgauuggaugguuuagugaggcccucggaucggccccg
ccggggugcccuggcggagcgcugagaagacggucgaacuugacuaucua
gaggaaguaaaagucguaacaagguuuccguaggugaaccugcggaagga
ucauua
...<<<<<.[.((((>>>>><<<.<<<<<<...<.<<..<......<<<.
<<<..<<....<<....<<..........>>...>>.>>......<<...
.....<<<.<....<<....<<<<<.........<<.....<<.<<<...
..>>>.>>......>>.........<<<<...<<<<<<....>>>>>>..
.>>>><<..<<<<<...<......>..>>>>>......>>...<<<<.<<
<..>>>>>>>.>>.>>>...>>..>.>>>.<<<....<<<....<<<<<<
<.........>>>>>>>>>>......>>>...<<<.<<<<....>>>>..
..>>>.>>.<<.<<<..........>>>.>>.<.<<....>>.>...>>>
>>>.........<<<....<<<<...>>>>..>>>..>...>>.>.....
<<<....<<.<<<....>>>..>>.....>>>......<<..<.......
....>..>>.........<<<<<((......<<<<.....<<..))>>..
.....>>>>.>>>>>..>>>>>>.>>>.........<.<((.....<.<<
...<<<.<<...<..>...<<<<<<.<.......<<...<.......>..
<<<.>>>....>>......>.>>>..>>>........<.<<.<<<<<<<.
..............>>>>>>>.>>.>....>>....<<<<<<..<...<<
<<..<<..<<<<<<<<...<<<......>>>......>>>>>>>>..>>.
......<<....>>...>>>>..>..>>>.>>>...>>>...>>.>....
<<<<<<<...<...<<<<.<.....>.>>>>...>>>>>>>>........
..<<<.<<.<<<..<.<<<<<<.<<<<<....>>>>>>>>>>>.>..>>>
...<<..))>>...>>.....>>>.>.>.<<<......<<<<....>>>>
....>>>..)))).]<<<<<.<<<<<<<..<<..<<<<<..<<<.<<<<.
<......<<........>>..........<<<<<......<<<<<<....
...<<.<<<........>>>.>>.....>>>>>>...<..<<<..<<.<<
<<<<....<<<.<<<<<....>>>...<<<......>>>...>>.>>>..
..<<<...<...<<<<..<<<<<<<<<<<..>>>.>>>>>>>>..>>>>.
.>.....<<<<<.....>>>>>........>>>....>>>.>>>.....>
>>>>.>.......>>>>>...>..>>>>.>>>.....<<.<<<.......
.<.<<<.<<<<....>>>>.>>>....>.........>>>.>>.......
.....<<<<<..........>>>>>...........>>>>>.....<<<<
<<<<.......>>>>>>>>......>>...>>>>>>>>>>.>>....<..
<<.<..<<<<.<<....<<<<<<<<.<<<..<<<<.<<...<<<<<<<<<
<<<<<<..>>>>>>>>>.>.>>>>>...>>.>>>>..>>>.>>>>>>>>.
..>>.>>>>...>.>>...>.....<<<<<<<<<....>>>>>>>>>...
......
Receptor-Ligand Complex Structure
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PDB7tql eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		H3 L6 Y7 W8 S9 H10 R12 F14 Q16 G17 R19 C24 N26 R27 H28 G29 L30 I31 R32 K33 Y34 R40 Q41 R44 K54 L55 D56
Binding residue
(residue number reindexed from 1)		H1 L4 Y5 W6 S7 H8 R10 F12 Q14 G15 R17 C22 N24 R25 H26 G27 L28 I29 R30 K31 Y32 R38 Q39 R42 K52 L53 D54
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003735 structural constituent of ribosome
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0002181 cytoplasmic translation
GO:0006412 translation
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005925 focal adhesion
GO:0015935 small ribosomal subunit
GO:0022626 cytosolic ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0070062 extracellular exosome
GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane
GO:1990904 ribonucleoprotein complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7tql, PDBe:7tql, PDBj:7tql
PDBsum7tql
PubMed35732735
UniProtP62273|RS29_HUMAN Small ribosomal subunit protein uS14 (Gene Name=RPS29)

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